Results 141 to 150 of about 1,578 (184)

Design, Synthesis, and Evaluation of Bis‐Chalcones and Bis‐Flavones as Selective COX‐2 Inhibitors

Chemical Biology &Drug Design, Volume 107, Issue 3, March 2026.
Novel bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition and the ability to inhibit PGE2 production in whole human blood. Notably, a monomeric chalcone with a similar substitution pattern exhibited even greater activity, providing valuable insights to guide the future design and optimization of flavonoid‐based COX‐2
Rui Pereira, Marisa Freitas, Alberto N. Araújo, Vera L. M. Silva, Eduarda Fernandes   +4 more
wiley   +1 more source

Artificial lipidation of proteins and peptides: from mechanism to clinical applications

The FEBS Journal, Volume 293, Issue 5, Page 1269-1284, March 2026.
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley   +1 more source

Hesperidin Encapsulation for Food, Pharmaceutical, and Chemical Industries: A Bibliometric Review

Journal of Food Process Engineering, Volume 49, Issue 3, March 2026.
The encapsulation of hesperidin in solid matrices is an excellent strategy for overcoming pharmacokinetic limitations while maintaining its antioxidant, antidiabetic, anti‐inflammatory, and neuroprotective properties. This study highlights the multidisciplinary scope of the research as well as the versatility of encapsulated hesperidin in the ...
Thais Fernanda de Marco, Luana Bettanin, Jaqueline Scapinello, Alexandre Tadeu Paulino   +3 more
wiley   +1 more source

Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context

Journal of Integrative Plant Biology, Volume 68, Issue 3, Page 694-718, March 2026.
Evolutionary gains and losses of key biosynthetic genes likely resulting from multiple independent evolutionary events explain why certain Nepeta (catnip) species produce both the active, cat‐attracting nepetalactones and sugar‐bound iridoids, while others make only the sugar‐bound forms, and some have lost iridoid production entirely.
Tijana Banjanac, Milica Milutinović, Dragana Matekalo, Neda Popović, Luka Petrović, Uroš Gašić, Marijana Skorić, Branislav Šiler, Tamara Lukić, Ana Stupar, Slavica Dmitrović, Jasmina Nestorović Živković, Biljana Filipović, Jelena Božunović, Miloš Todorović, Danijela Mišić   +15 more
wiley   +1 more source

Understanding the dynamic nature of plant lipid anabolic and catabolic metabolism is key to sustainable oilseed engineering

New Phytologist, Volume 249, Issue 5, Page 2196-2214, March 2026.
Summary Plant‐derived oils are essential sources of reduced carbon and various fatty acid (FA) structures for food, biofuels, and the oleochemical industry. Despite extensive efforts, engineering mainstream oilseed crops to produce high levels of industrially valuable unusual FAs (UFAs) remains challenging.
Prasad Parchuri, Sean T. McGuire, Matthew G. Garneau, Niña Alyssa M. Barroga, Philip D. Bates   +4 more
wiley   +1 more source

Engineering 2‐Pyrone‐4,6‐Dicarboxylic Acid Production Reveals Metabolic Plasticity of Poplar

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1398-1413, March 2026.
ABSTRACT Woody biomass is a promising source of fermentable sugars for biofuels and bio‐based chemicals, but its industrial use is limited by the costly biorefinery process. A viable strategy to reduce costs involves enhancing both biomass processability and the generation of high‐value co‐products.
Nidhi Dwivedi, Pingping Ji, Yang Tian, Dasmeet Kaur, Vijaya Kumar Reddy Vulavala, Yuki Tobimatsu, Aymerick Eudes, Chang‐Jun Liu   +7 more
wiley   +1 more source

The transformative power of structural predictions with AI in plant science

The Plant Journal, Volume 125, Issue 6, March 2026.
SUMMARY Since the introduction of various structural prediction programs, the emerging transformative power of these technologies in plant science is apparent. Not only programs like AlphaFold but also RoseTTAFold, Chai‐1 and Boltz suddenly enable plant scientists to predict structures with high confidence. This ability has facilitated the discovery of
Joy Chenqu Lyu, Renier A. L. Van der Hoorn   +1 more
wiley   +1 more source

Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
Pan et al. demonstrate that disruption of hepatic insulin signaling by insulin receptor (IR) substrate (IRS1/2) deletion led to impaired PI3K‐AKT signaling, causing increased Foxo1 activation and TGF‐β1 expression, which dysregulated the expression of the key enzymes involving phospholipid biosynthesis and remodeling.
Quan Pan, Meixia Pan, Weiqi Ai, Wanbao Yang, Wen Jiang, Xianlin Han, Shaodong Guo   +6 more
wiley   +1 more source

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Nucleophilic Acyl Substitution of Acyl Diimides

The Journal of Organic Chemistry, 2009
The nucleophilic acyl substitution of the acyl diimide intermediate formed by the oxidation of isoniazid was found to involve two methanol molecules in a six-membered cyclic transition state. Calculations were performed in the gas phase at the B3LYP/6-311+G(d,p)//B3LYP/6-31G(d) level of theory and solvation effects were included both explicitly and ...
Ruth I J, Amos, Carl H, Schiesser, Jason A, Smith, Brian F, Yates   +3 more
openaire   +2 more sources

Acylation of plant acyl carrier proteins by acyl-acyl carrier protein synthetase from Escherichia coli

Archives of Biochemistry and Biophysics, 1984
The acyl-acyl carrier protein synthetase from Escherichia coli has been examined for its ability to specifically acylate acyl carrier protein (ACP) from higher plants in order to develop an assay for plant ACP, and to prepare labeled acyl-ACP of plant origin. It was found that the E.
T M, Kuo, J B, Ohlrogge
openaire   +2 more sources