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Signal-transducing adaptor protein-2 modulates T-cell functions
Exploration of Immunology, 2022 Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades.
Tadashi Matsuda +6 more
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Exploration of Immunology, 2023 Adaptor proteins are involved in various immune responses via the modulation of many signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that contains typical domains such as the pleckstrin homology (PH) domain, Src ...
Yuto Sasaki +5 more
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Biomedicines, 2022 Adaptor molecules play a crucial role in signal transduction in immune cells. Several adaptor molecules, such as the linker for the activation of T cells (LAT) and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), are essential for T cell ...
Jun-ichi Kashiwakura +2 more
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Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness. [PDF]
, 2020 Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and the proper engagement of its intracellular signal effector proteins.
Becker, S. +10 more
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Virulence, 2023 Streptococcus suis type 2 (SS2), a major emerging/re-emerging zoonotic pathogen found in humans and pigs, can cause severe clinical infections, and pose public health issues.
Xiaowu Jiang +6 more
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In-cell biochemistry using NMR spectroscopy. [PDF]
PLoS ONE, 2008 Biochemistry and structural biology are undergoing a dramatic revolution. Until now, mostly in vitro techniques have been used to study subtle and complex biological processes under conditions usually remote from those existing in the cell.
David S Burz, Alexander Shekhtman
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Observation on the expression of P62 protein in common neurodegenerative diseases
Chinese Journal of Contemporary Neurology and Neurosurgery, 2019 Objective To evaluate the expression of P62 protein in the characteristic pathological changes of common neurodegenerative diseases and to explore its significance in pathological diagnosis. Methods Eleven cases of neurodegenerative diseases and 3 normal
Yuan⁃yuan WANG +6 more
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Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]
, 2006 Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
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The emerging and diverse roles of Src-like adaptor proteins in health and disease [PDF]
, 2014 Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered.
Baricza, Eszter +4 more
core +3 more sources
Expression of NEDD9 in Transbronchial Biopsies of Lung Adenocarcinoma
Acta Clinica Croatica, 2018 Lung cancer as the major cause of cancer mortality worldwide includes several histologic subtypes evolving from numerous genetic and epigenetic changes emerging in alveolar, bronchiolar and bronchial epithelium.
Jelena Ostojić +3 more
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