Results 11 to 20 of about 26,788 (222)

Signal-transducing adaptor protein-2 modulates T-cell functions

Exploration of Immunology, 2022
Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades. Signal-transducing adaptor protein-2 (STAP-2) contains typical features of adaptor proteins, like a pleckstrin homology (PH)
Tadashi Matsuda, Yuto Sasaki, Kota Kagohashi, Kodai Saitoh, Yuichi Sekine, Jun-Ichi Kashiwakura, Kenji Oritani   +6 more
openaire   +4 more sources

Potential therapeutic applications of targeting signal-transducing adaptor protein-2 in autoimmune diseases

Exploration of Immunology, 2023
Adaptor proteins are involved in various immune responses via the modulation of many signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that contains typical domains such as the pleckstrin homology (PH) domain, Src homology domain, and a proline-rich region from the N-terminal region.
Yuto Sasaki, Shoya Kawahara, Yuichi Sekine, Jun-Ichi Kashiwakura, Kenji Oritani, Tadashi Matsuda   +5 more
openaire   +3 more sources

The Functional Properties and Physiological Roles of Signal-Transducing Adaptor Protein-2 in the Pathogenesis of Inflammatory and Immune Disorders

Biomedicines, 2022
Adaptor molecules play a crucial role in signal transduction in immune cells. Several adaptor molecules, such as the linker for the activation of T cells (LAT) and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), are essential for T cell development and activation following T cell receptor (TCR) aggregation, suggesting that adaptor molecules
Jun-ichi Kashiwakura, Kenji Oritani, Tadashi Matsuda   +2 more
openaire   +5 more sources

Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications

Exploration of Targeted Anti-tumor Therapy
Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal transducer and activator of transcription 3 (STAT3)-binding motif in its C-terminal region.
Taiga Maemoto, Yuto Sasaki, Fumiya Okuyama, Yuichi Kitai, Kenji Oritani, Tadashi Matsuda   +5 more
openaire   +4 more sources

Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases

Experimental Hematology, 2022
Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment.
Michiko Ichii, Kenji Oritani, Jun Toda, Naoki Hosen, Tadashi Matsuda, Yuzuru Kanakura   +5 more
  +10 more sources

Modulation of TLR4 Signaling by a Novel Adaptor Protein Signal-Transducing Adaptor Protein-2 in Macrophages [PDF]

The Journal of Immunology, 2006
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies have demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways.
Yuichi, Sekine, Taro, Yumioka, Tetsuya, Yamamoto, Ryuta, Muromoto, Seiyu, Imoto, Kenji, Sugiyma, Kenji, Oritani, Kazuya, Shimoda, Mayu, Minoguchi, Shizuo, Akira, Akihiko, Yoshimura, Tadashi, Matsuda   +11 more
openaire   +2 more sources

Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis

Biological and Pharmaceutical Bulletin, 2021
Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis.
Sasaki, Yuto, Saitoh, Kodai, Kagohashi, Kota, Kitai, Yuichi, Muromoto, Ryuta, Oritani, Kenji, Kashiwakura, Jun-Ichi, Matsuda, Tadashi   +7 more
openaire   +4 more sources

Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma

Journal of Neuro-Oncology, 2023
Abstract Background Glioma is the most malignant primary brain tumor with a poor survival time. The tumour microenvironment, especially glioma-associated microglia/macrophages (GAMs), plays an important role in the pathogenesis of glioma.
Xinyu Yang, Chunxia Ji, Ying Qi, Jianhan Huang, Lang Hu, Yuan Zhou, Liping Zou, Yi Xia, Feng Tan, Yu Yao, Di Chen   +10 more
openaire   +2 more sources

Signal-Transducing Adaptor Protein-2 Controls the IgE-Mediated, Mast Cell–Mediated Anaphylactic Responses [PDF]

The Journal of Immunology, 2014
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules. In the current study, we clarified the physiological role of STAP-2 in mast cell function, a key mediator of IgE ...
Yuichi, Sekine, Keigo, Nishida, Satoru, Yamasaki, Ryuta, Muromoto, Shigeyuki, Kon, Jun-Ichi, Kashiwakura, Kodai, Saitoh, Sumihito, Togi, Akihiko, Yoshimura, Kenji, Oritani, Tadashi, Matsuda   +10 more
openaire   +2 more sources

Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition

Virulence, 2023
Streptococcus suis type 2 (SS2), a major emerging/re-emerging zoonotic pathogen found in humans and pigs, can cause severe clinical infections, and pose public health issues.
Xiaowu Jiang, Guijun Yu, Lexin Zhu, Abubakar Siddique, Dongbo Zhan, Linhua Zhou, Min Yue   +6 more
doaj   +1 more source