Results 11 to 20 of about 33,819 (267)

Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications

Exploration of Targeted Anti-tumor Therapy
Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal ...
Taiga Maemoto, Yuto Sasaki, Fumiya Okuyama, Yuichi Kitai, Kenji Oritani, Tadashi Matsuda   +5 more
doaj   +3 more sources

Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases

Experimental Hematology, 2022
Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment.
Michiko Ichii, Kenji Oritani, Jun Toda, Naoki Hosen, Tadashi Matsuda, Yuzuru Kanakura   +5 more
  +10 more sources

Modulation of TLR4 Signaling by a Novel Adaptor Protein Signal-Transducing Adaptor Protein-2 in Macrophages [PDF]

The Journal of Immunology, 2006
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies have demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways.
Yuichi, Sekine, Taro, Yumioka, Tetsuya, Yamamoto, Ryuta, Muromoto, Seiyu, Imoto, Kenji, Sugiyma, Kenji, Oritani, Kazuya, Shimoda, Mayu, Minoguchi, Shizuo, Akira, Akihiko, Yoshimura, Tadashi, Matsuda   +11 more
openaire   +2 more sources

Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis

Biological and Pharmaceutical Bulletin, 2021
Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis.
Sasaki, Yuto, Saitoh, Kodai, Kagohashi, Kota, Kitai, Yuichi, Muromoto, Ryuta, Oritani, Kenji, Kashiwakura, Jun-Ichi, Matsuda, Tadashi   +7 more
openaire   +4 more sources

Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma

Journal of Neuro-Oncology, 2023
Abstract Background Glioma is the most malignant primary brain tumor with a poor survival time. The tumour microenvironment, especially glioma-associated microglia/macrophages (GAMs), plays an important role in the pathogenesis of glioma.
Xinyu Yang, Chunxia Ji, Ying Qi, Jianhan Huang, Lang Hu, Yuan Zhou, Liping Zou, Yi Xia, Feng Tan, Yu Yao, Di Chen   +10 more
openaire   +2 more sources

Signal-Transducing Adaptor Protein-2 Controls the IgE-Mediated, Mast Cell–Mediated Anaphylactic Responses [PDF]

The Journal of Immunology, 2014
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules. In the current study, we clarified the physiological role of STAP-2 in mast cell function, a key mediator of IgE ...
Yuichi, Sekine, Keigo, Nishida, Satoru, Yamasaki, Ryuta, Muromoto, Shigeyuki, Kon, Jun-Ichi, Kashiwakura, Kodai, Saitoh, Sumihito, Togi, Akihiko, Yoshimura, Kenji, Oritani, Tadashi, Matsuda   +10 more
openaire   +2 more sources

Constitutive internalization and association with adaptor protein‐2 of the interleukin‐6 signal transducer gp130 [PDF]

FEBS Letters, 1998
The transmembrane protein gp130 is the common signalling receptor subunit for the interleukin‐6 (IL‐6)‐type cytokines. It has recently been shown that the cytoplasmic domain of gp130 contains a dileucine internalization motif and that endocytosis of gp130 occurs signal‐independent.
Thiel, Stefan, Dahmen, Heike, Martens, Astrid, Müller-Newen, Gerhard, Schaper, Fred, Heinrich, Peter, Graeve, Lutz   +6 more
openaire   +3 more sources

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress

Haematologica, 2020
Signal-transducing adaptor protein-2 (STAP-2) was discovered as a C-FMS/M-CSFR interacting protein and subsequently found to function as an adaptor of signaling or transcription factors. These include STAT5, MyD88 and IκB kinase in macrophages, mast cells, and T cells. There is additional information about roles for STAP-2 in several types of malignant
Michiko Ichii, Kenji Oritani, Jun Toda, Hideaki Saito, Henyun Shi, Hirohiko Shibayama, Daisuke Motooka, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Daisuke Okuzaki, Tadashi Matsuda, Yuzuru Kanakura   +13 more
openaire   +4 more sources

Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation

Biochemical and Biophysical Research Communications, 2021
Signal-transducing adaptor protein (STAP)-2 is one of the STAP family adaptor proteins and ubiquitously expressed in a variety types of cells. Although STAP-2 is required for modification of FcεRI signal transduction in mast cells, other involvement of STAP-2 in mast cell functions is unknown, yet.
Jun-ichi Kashiwakura, Nao Koizumi, Kodai Saitoh, Kota Kagohashi, Yuto Sasaki, Fuki Kobayashi, Shoya Kawahara, Yukie Yamauchi, Yuichi Kitai, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda   +11 more
openaire   +3 more sources

Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. [PDF]

The EMBO Journal, 1996
The serine protease thrombin activates G protein signaling systems that lead to Ras activation and, in certain cells, proliferation. Whereas the steps leading to Ras activation by G protein-coupled receptors are not well defined, the mechanisms of Ras activation by receptor tyrosine kinases have recently been elucidated biochemically and genetically ...
Y. Chen, D. Grall, A. E. Salcini, P. G. Pelicci, J. Pouysségur, E. Van Obberghen Schilling   +5 more
openaire   +3 more sources