Signal-Transducing Adaptor Protein-2 Modulates Fas-Mediated T Cell Apoptosis by Interacting with Caspase-8 [PDF]
The Journal of Immunology, 2012 Abstract We found that an adaptor protein, signal-transducing adaptor protein (STAP)-2, is a new member of the Fas–death-inducing signaling complex and participates in activation-induced cell death in T cells. STAP-2 enhanced Fas-mediated apoptosis and caspase-8 aggregation and activation in Jurkat T cells.
Yuichi, Sekine +9 more
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Caracterización de la cadena CD3 épsilon en el primate del nuevo mundo Aotus nancymaae
Biomédica: revista del Instituto Nacional de Salud, 2008 Introducción. El complejo asociado al receptor de las células T está constituido por las moléculas CD3 (δ, γ, ε) y las cadenas ζ, todas proteínas transmembrana esenciales para la transducción de señales durante la activación del linfocito y la respuesta ...
Jean Paul Vernot, Hernando del Castillo
doaj +1 more source
S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway [PDF]
, 2012 Peer reviewedPublisher ...
Berg, Daniela +12 more
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Frontiers in Molecular Neuroscience, 2016 Integrin-mediated cell adhesion and signaling is of critical importance for neuronal differentiation. Recent evidence suggests that an inside-out activation of β1-integrin, similar to that observed in hematopoietic cells, contributes to the growth and ...
Marlen Thiere +6 more
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Stoichiometry and intracellular fate of TRIM-containing TCR complexes [PDF]
, 2010 Background: Studying the stoichiometry and intracellular trafficking of the T cell antigen receptor (TCR) is pivotal in understanding its mechanisms of activation. The αβTCR includes the antigen-binding TCRαβ heterodimer as well as the signal transducing
Dopfer, Elaine P. +7 more
core +3 more sources
Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1α-Induced Chemotaxis in T Cells [PDF]
The Journal of Immunology, 2009 AbstractSignal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains, as well as a YXXQ motif in its C-terminal region. Our previous studies revealed that STAP-2 regulates integrin-mediated T cell adhesion.
Yuichi, Sekine +8 more
openaire +2 more sources
The role of Crk adaptor proteins in T cell adhesion and migration
Frontiers in Immunology, 2015 Crk adaptor proteins are key players in signal transduction from a variety of cell surface receptors. They are involved in early steps of lymphocyte activation through their SH2-mediated transient interaction with signal transducing effector molecules ...
Noah eIsakov, Alex eBraiman
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Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma [PDF]
, 2015 The prevalence of global obesity is increasing. Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers.
Alfraidi, Albandri +5 more
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Signal-Transducing Adaptor Protein-2 Regulates Integrin-Mediated T Cell Adhesion through Protein Degradation of Focal Adhesion Kinase [PDF]
The Journal of Immunology, 2007 Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin homology- and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways. In the present
Yuichi, Sekine +9 more
openaire +2 more sources
Emerging targets in human lymphoma: targeting the MYD88 mutation [PDF]
, 2016 B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link ...
Horikawa, Keisuke +2 more
core +1 more source