Results 21 to 30 of about 26,788 (222)

In-cell biochemistry using NMR spectroscopy. [PDF]

PLoS ONE, 2008
Biochemistry and structural biology are undergoing a dramatic revolution. Until now, mostly in vitro techniques have been used to study subtle and complex biological processes under conditions usually remote from those existing in the cell.
David S Burz, Alexander Shekhtman
doaj   +1 more source

Constitutive internalization and association with adaptor protein‐2 of the interleukin‐6 signal transducer gp130 [PDF]

FEBS Letters, 1998
The transmembrane protein gp130 is the common signalling receptor subunit for the interleukin‐6 (IL‐6)‐type cytokines. It has recently been shown that the cytoplasmic domain of gp130 contains a dileucine internalization motif and that endocytosis of gp130 occurs signal‐independent.
Thiel, Stefan, Dahmen, Heike, Martens, Astrid, Müller-Newen, Gerhard, Schaper, Fred, Heinrich, Peter, Graeve, Lutz   +6 more
openaire   +3 more sources

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress

Haematologica, 2020
Signal-transducing adaptor protein-2 (STAP-2) was discovered as a C-FMS/M-CSFR interacting protein and subsequently found to function as an adaptor of signaling or transcription factors. These include STAT5, MyD88 and IκB kinase in macrophages, mast cells, and T cells. There is additional information about roles for STAP-2 in several types of malignant
Michiko Ichii, Kenji Oritani, Jun Toda, Hideaki Saito, Henyun Shi, Hirohiko Shibayama, Daisuke Motooka, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Daisuke Okuzaki, Tadashi Matsuda, Yuzuru Kanakura   +13 more
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Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation

Biochemical and Biophysical Research Communications, 2021
Signal-transducing adaptor protein (STAP)-2 is one of the STAP family adaptor proteins and ubiquitously expressed in a variety types of cells. Although STAP-2 is required for modification of FcεRI signal transduction in mast cells, other involvement of STAP-2 in mast cell functions is unknown, yet.
Jun-ichi Kashiwakura, Nao Koizumi, Kodai Saitoh, Kota Kagohashi, Yuto Sasaki, Fuki Kobayashi, Shoya Kawahara, Yukie Yamauchi, Yuichi Kitai, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda   +11 more
openaire   +3 more sources

Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. [PDF]

The EMBO Journal, 1996
The serine protease thrombin activates G protein signaling systems that lead to Ras activation and, in certain cells, proliferation. Whereas the steps leading to Ras activation by G protein-coupled receptors are not well defined, the mechanisms of Ras activation by receptor tyrosine kinases have recently been elucidated biochemically and genetically ...
Y. Chen, D. Grall, A. E. Salcini, P. G. Pelicci, J. Pouysségur, E. Van Obberghen Schilling   +5 more
openaire   +3 more sources

Observation on the expression of P62 protein in common neurodegenerative diseases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To evaluate the expression of P62 protein in the characteristic pathological changes of common neurodegenerative diseases and to explore its significance in pathological diagnosis. Methods Eleven cases of neurodegenerative diseases and 3 normal
Yuan⁃yuan WANG, Ming⁃wei ZHU, Lu⁃ning WANG, Hong⁃hong ZHANG, Ya⁃zhuo HU, Zhi⁃tao HAN , Ying⁃han ZHANG   +6 more
doaj   +1 more source

Signal-Transducing Adaptor Protein-2 Modulates Fas-Mediated T Cell Apoptosis by Interacting with Caspase-8 [PDF]

The Journal of Immunology, 2012
Abstract We found that an adaptor protein, signal-transducing adaptor protein (STAP)-2, is a new member of the Fas–death-inducing signaling complex and participates in activation-induced cell death in T cells. STAP-2 enhanced Fas-mediated apoptosis and caspase-8 aggregation and activation in Jurkat T cells.
Yuichi, Sekine, Chikako, Yamamoto, Michinori, Kakisaka, Ryuta, Muromoto, Shigeyuki, Kon, Dai, Ashitomi, Natsuko, Fujita, Akihiko, Yoshimura, Kenji, Oritani, Tadashi, Matsuda   +9 more
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Expression of NEDD9 in Transbronchial Biopsies of Lung Adenocarcinoma

Acta Clinica Croatica, 2018
Lung cancer as the major cause of cancer mortality worldwide includes several histologic subtypes evolving from numerous genetic and epigenetic changes emerging in alveolar, bronchiolar and bronchial epithelium.
Jelena Ostojić, Luka Brčić, Pero Hrabač, Sven Seiwerth   +3 more
doaj   +1 more source

Caracterización de la cadena CD3 épsilon en el primate del nuevo mundo Aotus nancymaae

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. El complejo asociado al receptor de las células T está constituido por las moléculas CD3 (δ, γ, ε) y las cadenas ζ, todas proteínas transmembrana esenciales para la transducción de señales durante la activación del linfocito y la respuesta ...
Jean Paul Vernot, Hernando del Castillo
doaj   +1 more source

Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1α-Induced Chemotaxis in T Cells [PDF]

The Journal of Immunology, 2009
AbstractSignal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains, as well as a YXXQ motif in its C-terminal region. Our previous studies revealed that STAP-2 regulates integrin-mediated T cell adhesion.
Yuichi, Sekine, Osamu, Ikeda, Satoshi, Tsuji, Chikako, Yamamoto, Ryuta, Muromoto, Asuka, Nanbo, Kenji, Oritani, Akihiko, Yoshimura, Tadashi, Matsuda   +8 more
openaire   +2 more sources