Results 1 to 10 of about 3,997 (140)

ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics [PDF]

Molecular Neurodegeneration, 2010
Background Thiamine (vitamin B1) deficiency (TD) causes mild impairment of oxidative metabolism and region-selective neuronal loss in the central nervous system (CNS).
Liu Yong, Fan Zhiqin, Wan Yanjie, Feng Chun, Xu Jing, Zhang Xiaomin, Zhao Liyun, Liu Ying, Yong Yue, Yang Guang, Lee Shuchen, Luo Jia, Ke Zun-Ji   +12 more
doaj   +3 more sources

RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond [PDF]

Scientific Reports
RNA modifications in the brain can be essential for regulating the transcriptome and brain function. Our study unveils the landscape of different RNA modifications associated with splicing within the mouse brain.
Erika Larrea, Maitena Tellaetxe-Abete, Yan Peng, Yujie Zhang, Shuangshuang Feng, Kaidong Lu, Liang Xue, Taisuke Nakahama, Yukio Kawahara, Magdalena J. Koziol   +9 more
doaj   +2 more sources

Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2 [PDF]

Cellular & Molecular Biology Letters
Background Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, characterized by its poor prognosis. Glycolipid metabolism is strongly associated with GBM development and malignant behavior.
Zheng Cui, Xiaobai Liu, Tiange E, Hongda Lin, Di Wang, Yunhui Liu, Xuelei Ruan, Ping Wang, Libo Liu, Yixue Xue   +9 more
doaj   +2 more sources

TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data [PDF]

Genome Biology
RNA editing by adenosine deaminases acting on RNA (ADARs) is an essential cellular process performed by three enzymes in mammals: ADAR1-p150, ADAR1-p110, and ADAR2, demonstrating different target specificity and selectivity.
Maike Herrmann, Yvonne Krebs, Francisco M. Acosta, Sebastian Parusel, Oliver Siering, Felix G. M. Andres, Biruhalem Taye, Csaba Miskey, Christian K. Pfaller   +8 more
doaj   +2 more sources

ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature

Biomolecules, 2022
Background: Epitranscriptomic mechanisms, such as A-to-I RNA editing mediated by ADAR deaminases, contribute to cancer heterogeneity and patients’ stratification.
Valeriana Cesarini, Domenico Alessandro Silvestris, Federica Galeano, Valentina Tassinari, Maurizio Martini, Franco Locatelli, Angela Gallo   +6 more
doaj   +1 more source

c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells. [PDF]

PLoS ONE, 2012
A-to-I RNA editing catalyzed by the two main members of the adenosine deaminase acting on RNA (ADAR) family, ADAR1 and ADAR2, represents a RNA-based recoding mechanism implicated in a variety of cellular processes.
Liu Yang, Ping Huang, Feng Li, Liyun Zhao, Yongliang Zhang, Shoufeng Li, Zhenji Gan, Anning Lin, Wenjun Li, Yong Liu   +9 more
doaj   +1 more source

Zebrafish Adar2 Edits the Q/R site of AMPA receptor Subunit gria2α transcript to ensure normal development of nervous system and cranial neural crest cells. [PDF]

PLoS ONE, 2014
BackgroundAdar2 deaminates selective adenosines to inosines (A-to-I RNA editing) in the double-stranded region of nuclear transcripts. Although the functions of mouse Adar2 and its biologically most important substrate gria2, encoding the GluA2 subunit ...
I-Chen Li, Yu-Chia Chen, Yi-Yun Wang, Bo-Wei Tzeng, Chun-Wen Ou, Yi-Yan Lau, Kan-Mai Wu, Tzu-Min Chan, Wei-Hsiang Lin, Sheng-Ping L Hwang, Wei-Yuan Chow   +10 more
doaj   +1 more source

Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons. [PDF]

PLoS ONE, 2012
TDP-43 pathology in spinal motor neurons is a neuropathological hallmark of sporadic amyotrophic lateral sclerosis (ALS) and has recently been shown to be closely associated with the downregulation of an RNA editing enzyme called adenosine deaminase ...
Takuto Hideyama, Sayaka Teramoto, Kosuke Hachiga, Takenari Yamashita, Shin Kwak   +4 more
doaj   +1 more source

Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2

Nature Communications, 2023
Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and/or ADAR2 at varying levels, raising the question of what are the determinants guiding substrate specificity and how these differ between the two enzymes.
Marlon S. Zambrano-Mila, Monika Witzenberger, Zohar Rosenwasser, Anna Uzonyi, Ronit Nir, Shay Ben-Aroya, Erez Y. Levanon, Schraga Schwartz   +7 more
doaj   +1 more source

Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. [PDF]

, 2015
Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression.
Alon, S, Eisenberg, E, Galardi, S, Galeano, F, Gallo, A., Locatelli, F, Polito, V, Presutti, Carlo, Raho, S, Tomaselli, S, Vincenti, S   +10 more
core   +2 more sources