Results 1 to 10 of about 1,976 (156)

When does ALS start? ADAR2-GluA2 hypothesis for the etiology of sporadic ALS [PDF]

Frontiers in Molecular Neuroscience, 2011
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. More than 90% of ALS cases are sporadic, and the majority of sporadic ALS patients do not carry mutations in genes causative of familial ALS; therefore ...
Takuto eHideyama, Takuto eHideyama, Shin eKwak, Shin eKwak   +3 more
doaj   +3 more sources

Novel exon of mammalian ADAR2 extends open reading frame.

PLoS ONE, 2009
BackgroundThe post-transcriptional processing of pre-mRNAs by RNA editing contributes significantly to the complexity of the mammalian transcriptome. RNA editing by site-selective A-to-I modification also regulates protein function through recoding of ...
Stefan Maas, Willemijn M Gommans
doaj   +3 more sources

Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]

Nucleic Acids Research, 2016
Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core   +6 more sources

Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2

Nature Communications, 2023
Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and/or ADAR2 at varying levels, raising the question of what are the determinants guiding substrate specificity and how these differ between the two enzymes.
Marlon S. Zambrano-Mila, Monika Witzenberger, Zohar Rosenwasser, Anna Uzonyi, Ronit Nir, Shay Ben-Aroya, Erez Y. Levanon, Schraga Schwartz   +7 more
doaj   +3 more sources

Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. [PDF]

Genome Biology, 2015
Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression.
Alon, S, Eisenberg, E, Galardi, S, Galeano, F, Gallo, A., Locatelli, F, Polito, V, Presutti, Carlo, Raho, S, Tomaselli, S, Vincenti, S   +10 more
core   +7 more sources

The effect of ADAR2 in osteosarcoma

Bone Reports, 2020
Michela Rossi, Viviana De Martino, Giulia Battafarano, Eda Mariani, Valeriana Cesarini, Salvatore Minisola, Angela Gallo, Andrea Del Fattore   +7 more
doaj   +2 more sources

The RNA editing enzyme ADAR2 restricts L1 mobility [PDF]

RNA Biology, 2021
Adenosine deaminases acting on RNA (ADARs) are enzymes that convert adenosines to inosines in double-stranded RNAs (RNA editing A-to-I). ADAR1 and ADAR2 were previously reported as HIV-1 proviral factors. The aim of this study was to investigate the composition of the ADAR2 ribonucleoprotein complex during HIV-1 expression. By using a dual-tag affinity
Frassinelli L., Orecchini E., Al-Wardat S., Tripodi M., Mancone C., Doria M., Galardi S., Ciafre S. A., Michienzi A.   +8 more
openaire   +4 more sources

ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature

Biomolecules, 2022
Background: Epitranscriptomic mechanisms, such as A-to-I RNA editing mediated by ADAR deaminases, contribute to cancer heterogeneity and patients’ stratification.
Valeriana Cesarini, Domenico Alessandro Silvestris, Federica Galeano, Valentina Tassinari, Maurizio Martini, Franco Locatelli, Angela Gallo   +6 more
doaj   +1 more source

c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells. [PDF]

PLoS ONE, 2012
A-to-I RNA editing catalyzed by the two main members of the adenosine deaminase acting on RNA (ADAR) family, ADAR1 and ADAR2, represents a RNA-based recoding mechanism implicated in a variety of cellular processes.
Liu Yang, Ping Huang, Feng Li, Liyun Zhao, Yongliang Zhang, Shoufeng Li, Zhenji Gan, Anning Lin, Wenjun Li, Yong Liu   +9 more
doaj   +1 more source

ADAR2-dependent GluA2 editing regulates cocaine seeking [PDF]

Molecular Psychiatry, 2014
Activation of AMPA receptors (AMPARs) in the nucleus accumbens is necessary for the reinstatement of cocaine-seeking behavior, an animal model of drug craving and relapse. AMPARs are tetrameric protein complexes that consist of GluA1-4 subunits, of which GluA2 imparts calcium permeability. Adenosine deaminase acting on RNA 2 (ADAR2) is a nuclear enzyme
Schmidt, H.D., McFarland, K.N., Darnell, S.B., Huizenga, M.N., Sangrey, G.R., Cha, J.-H.J., Pierce, R.C., Sadri-Vakili, G.   +7 more
openaire   +2 more sources