Results 91 to 100 of about 1,976 (156)
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD [PDF]
Acta Neuropathologica, 2019 The hexanucleotide repeat expansion GGGGCC (G4C2)n in the C9orf72 gene is the most common genetic abnormality associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent findings suggest that dysfunction of nuclear-cytoplasmic trafficking could affect the transport of RNA binding proteins in C9orf72 ALS/FTD.
Stephen, Moore +17 more
openaire +2 more sources
Advanced Science, Volume 12, Issue 28, July 24, 2025.CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi +8 more
wiley +1 more source
Structure and Specific RNA Binding of ADAR2 Double-Stranded RNA Binding Motifs [PDF]
Structure, 2006 Adenosine deaminases that act on RNA (ADARs) site-selectively modify adenosines to inosines within RNA transcripts, thereby recoding genomic information. How ADARs select specific adenosine moieties for deamination is poorly understood. Here, we report NMR structures of the two double-stranded RNA binding motifs (dsRBMs) of rat ADAR2 and an NMR ...
Stefl, Richard +4 more
openaire +2 more sources
Petits ARN C/D et syndrome de Prader-Willi [PDF]
, 2005 International ...
Cavaillé, Jérôme, Vitali, Patrice
core +2 more sources
Advanced Science, Volume 12, Issue 25, July 3, 2025.During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li +15 more
wiley +1 more source
Involvement of RNA-editing enzyme and multi-factor to motor neuron death in patients with sporadic amyotrophic lateral sclerosis [PDF]
, 2012 科学研究費助成事業(科学研究費補助金)研究成果報告書：基盤研究(C)2009-2011課題番号 ...
TAKUMA HIROSHI, 詫間 浩
core
Current developments in gene therapy for amyotrophic lateral sclerosis. [PDF]
, 2015 INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a devastating adult neurodegenerative disorder characterized by motor neuron degeneration and death around 3 years from onset.
Alrafiah, A.R. +4 more
core +1 more source
Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain [PDF]
RNA, 2006 Members of the family of adenosine deaminases acting on RNA (ADARs) can catalyze the hydrolytic deamination of adenosine to inosine and thereby change the sequence of specific mRNAs with highly double-stranded structures. The ADARs all contain one or more repeats of the double-stranded RNA binding motif (DRBM).
Poulsen, Hanne +5 more
openaire +3 more sources
RNA editing system: Balancing altruistic antiviral defense and fitness trade‐offs in fungi
mLife, Volume 4, Issue 6, Page 597-601, December 2025.
Yanfei Du, Daohong Jiang, Huiquan Liu
wiley +1 more source
Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges
Advanced Genetics, Volume 6, Issue 2, June 2025.This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley +1 more source