Results 41 to 50 of about 4,066 (198)
Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer. [PDF]
PLoS ONE, 2012 Lung cancer is a leading cause of cancer death worldwide. Several alterations in RNA metabolism have been found in lung cancer cells; this suggests that RNA metabolism-related molecules are involved in the development of this pathology. In this study, we
Iñaki Valles +8 more
doaj +1 more source
Modulation of ADAR mRNA expression in patients with congenital heart defects.
PLoS ONE, 2019 Adenosine (A) to inosine (I) RNA editing is a hydrolytic deamination reaction catalyzed by the adenosine deaminase (ADAR) enzyme acting on double-stranded RNA.
Faiza Altaf +5 more
doaj +1 more source
ADAR2-mediated Q/R editing of GluA2 in homeostatic synaptic plasticity. [PDF]
Sci SignalHomeostatic synaptic plasticity is a negative feedback mechanism through which neurons modify their synaptic strength to counteract chronic increases or decreases in activity. In response to activity deprivation, synaptic strength is enhanced by increasing the number of AMPA receptors (AMPARs), particularly Ca 2 ...
Peterson L +4 more
europepmc +3 more sources
Nature Communications, 2020 Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalian ...
Patricia Deng +11 more
doaj +1 more source
Molecular Oncology, 2022 We previously observed increased levels of adenosine‐deaminase‐acting‐on‐dsRNA (Adar)‐dependent RNA editing during mesothelioma development in mice exposed to asbestos.
Ananya Hariharan +19 more
doaj +1 more source
Cell Reports, 2018 Summary: Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis.
Phillip M. Shelton +14 more
doaj +1 more source
New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]
, 2015 The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana +4 more
core +2 more sources
Conservation of A-to-I RNA editing in bowhead whale and pig
PLoS ONE, 2021 RNA editing is a post-transcriptional process in which nucleotide changes are introduced into an RNA sequence, many of which can contribute to proteomic sequence variation.
Knud Larsen, Mads Peter Heide-Jørgensen
doaj +3 more sources
What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs [PDF]
Open Biology, 2020 Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.
Jacki E. Heraud-Farlow +1 more
doaj +1 more source
ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas [PDF]
BMC Cancer, 2013 Abstract Background High-grade (WHO grade III and IV) astrocytomas are aggressive malignant brain tumors affecting humans with a high risk of recurrence in both children and adults. To date, limited information is available on the genetic and molecular alterations important in the onset and progression of pediatric ...
Tomaselli, S +7 more
openaire +4 more sources