An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme [PDF]
, 2009 RNA editing by adenosine deamination is particularly prevalent in the squid nervous system. We hypothesized that the squid editing enzyme might contain structural differences that help explain this phenomenon. As a first step, a squid adenosine deaminase
O'Connell, Mary A +2 more
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Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain [PDF]
, 2018 In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process.
Barbon, Alessandro +6 more
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ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas [PDF]
BMC Cancer, 2013 Abstract Background High-grade (WHO grade III and IV) astrocytomas are aggressive malignant brain tumors affecting humans with a high risk of recurrence in both children and adults. To date, limited information is available on the genetic and molecular alterations important in the onset and progression of pediatric ...
Tomaselli, S +7 more
openaire +4 more sources
PLoS Pathogens, 2022 ADARs (adenosine deaminases acting on RNA) are known for their adenosine-to-inosine RNA editing activity, and most recently, for their role in preventing aberrant dsRNA-response by activation of dsRNA sensors (i.e., RIG-I-like receptor homologs). However,
Dan Bar Yaacov
doaj +1 more source
Suppression of RNA editing by miR-17 inhibits the stemness of melanoma stem cells
Molecular Therapy: Nucleic Acids, 2022 More and more evidence suggests that microRNA (miRNA) and RNA editing play key roles in the development and progression of tumor. However, the influence of miRNA-mediated RNA editing on tumor stem cells remains unclear.
Yu Zhang +3 more
doaj +1 more source
ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. [PDF]
PLoS ONE, 2013 A growing list of microRNAs (miRNAs) show aberrant expression patterns in hepatocellular carcinoma (HCC), but the regulatory mechanisms largely remain unclear.
Wan-Hsin Liu +7 more
doaj +1 more source
A-to-I RNA editing in the earliest-diverging Eumetazoan phyla [PDF]
, 2017 © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology and Evolution 34 (2017): 1890-1901, doi:10.1093/molbev/msx125.The highly conserved ...
Alon, Shahar +7 more
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Journal of Pharmacological Sciences, 2010 The motor neurons of patients with sporadic amyotrophic lateral sclerosis (ALS) express abundant Q/R site–unedited GluR2 mRNA, whereas those of patients with other motor neuron diseases including familial ALS associated with mutated SOD1 (ALS1) and those
Takuto Hideyama +4 more
doaj +1 more source
Developing PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing
Cell Communication and Signaling, 2021 RNA base editing is potential for cellular function research and genetic diseases treating. There are two main RNA base editors, REPAIR and RESCUE, for in vitro use.
Guo Li +6 more
doaj +1 more source
Abnormal expression of an ADAR2 alternative splicing variant in gliomas downregulates adenosine-to-inosine RNA editing [PDF]
, 2014 BACKGROUND: RNA editing is catalyzed by adenosine deaminases acting on RNA (ADARs). ADAR2 is the main enzyme responsible for recoding editing in humans. Adenosine-to-inosine (A-to-I) editing at the Q/R site is reported to be decreased in gliomas; however,
Bin Qi +11 more
core +1 more source