4-Thioribose Analogues of Adenosine Diphosphate Ribose (ADPr) Peptides. [PDF]
Org Lett, 2023 Adenosine diphosphate (ADP) ribosylation is an important post-translational modification (PTM) that plays a role in a wide variety of cellular processes. To study the enzymes responsible for the establishment, recognition, and removal of this PTM, stable analogues are invaluable tools.
Madern JM +7 more
europepmc +7 more sources
Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca(2+) signaling pathway. [PDF]
World J Biol Chem, 2014 published_or_final_versio
Wei W, Graeff R, Yue J.
europepmc +5 more sources
Expression of poly(Adenosine Diphosphate-Ribose) polymerase protein in breast cancer [PDF]
Journal of Mid-Life Health, 2022 Background: The use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors for breast cancer (BC) therapy is the subject of debate, and there is an urgent need to understand much the expression and prognostic role of the PARP1 protein.
Akanksha +6 more
doaj +2 more sources
Synthesis of Well‐Defined Adenosine Diphosphate Ribose Oligomers [PDF]
Angewandte Chemie International Edition, 2015 AbstractThe post‐translational modification of proteins that is known as adenosine diphosphate ribosylation (ADPr) regulates a wide variety of important biological processes, such as DNA‐damage repair and cellular metabolism. This modification is also involved in carcinogenesis and the process of aging. Therefore, a better understanding of the function
Kistemaker, H.A.V. +5 more
openaire +4 more sources
Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy [PDF]
Biomolecules, 2012 Treatments with Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors have offered patients carrying cancers with mutated BRCA1 or BRCA2 genes a new and in many cases effective option for disease control.
Thomas Helleday, Cecilia E. Ström
doaj +2 more sources
Poly Adenosine Diphosphate-Ribose Polymerase (PARP) Inhibitors in Pancreatic Cancer. [PDF]
Cureus, 2022 Pancreatic cancer is the third most common cause of cancer death in the United States and eleventh worldwide. The majority of patients present with advanced disease with five-year overall survival of less than 10%. Traditional chemotherapy has been the mainstay treatment for years, with limited improvement in survival.
Sunkara T +5 more
europepmc +4 more sources
Blocking Cyclic Adenosine Diphosphate Ribose-mediated Calcium Overload Attenuates Sepsis-induced Acute Lung Injury in Rats [PDF]
Chinese Medical Journal, 2016 Background: Acute lung injury (ALI) is a common complication of sepsis that is associated with high mortality. Intracellular Ca2+ overload plays an important role in the pathophysiology of sepsis-induced ALI, and cyclic adenosine diphosphate ribose ...
Qian-Yi Peng +5 more
doaj +2 more sources
Prognostic and clinicopathological value of poly (adenosine diphosphate-ribose) polymerase expression in breast cancer: A meta-analysis. [PDF]
PLoS ONE, 2017 BACKGROUND:Previous studies have shown that the poly (adenosine diphosphate-ribose) polymerase (PARP) level is a promising indicator of breast cancer. However, its prognostic value remains controversial. The present meta-analysis evaluated the prognostic
Weiqiang Qiao +4 more
doaj +2 more sources
Poly(Adenosine diphosphate-ribose) polymerase inhibitors in cancer treatment. [PDF]
Hematol Oncol Clin North Am, 2012 Recently, the development of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors as a synthetic lethality approach has brought a major breakthrough in the treatment of breast cancer susceptibility gene (BRCA)-mutant cancers. Because sporadic cancers have also been found to commonly have other defects in DNA repair, PARP inhibitors are under
Park SR, Chen A.
europepmc +4 more sources
Poly–adenosine diphosphate–ribose polymerase inhibition for myocardial protection: Pathophysiologic and physiologic considerations [PDF]
, 2004 Plantilles de l’Institut Barcelona Esports, de l’Institut Municipal del Paisatge Urbà i la Qualitat de Vida, de l’Institut Municipal d'Informàtica, de l’Institut Municipal d'Hisenda, de l’Institut Municipal d'Educació, de l’Institut Municipal de Mercats,
Wilhelm Bloch +7 more
core +3 more sources