Results 91 to 100 of about 25,770 (257)

Remote delivery of cancer genetic testing in veterans with metastatic prostate cancer: A Million Veteran Program pilot study

Cancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Germline pathogenic variants can inform targeted therapy for metastatic prostate cancer (mPC), and improve cancer early detection and risk reduction for family members. Guidelines recommend germline genetic testing be offered to all men with mPC, yet uptake of testing is only 10%–12%. Methods This prospective study enrolled veterans
Bruce Montgomery, Julie A. Lynch, Jessica Brown, Kara N. Maxwell, Craig C. Teerlink, Nismeta Kabilovic, Katie Stoll, Julie Simon, Maria Kogan, Sajida Hassan, Stacey B. Whitbourne, Sumitra Muralidhar, Martin W. Schoen, Rachel Ramoni, J. Michael Gaziano, Alexandra O. Sokolova, Heather H. Cheng, Ruth Etzioni, Colin C. Pritchard   +18 more
wiley   +1 more source

Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients [PDF]

, 2017
International audienceThe approval, in 2015, of the first poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi; olaparib, Lynparza) for platinum-sensitive relapsed high-grade ovarian cancer with either germline or somatic BRCA1/2 deleterious ...
Banerjee, Susana, Bryce, Jane, Büttner, Reinhard, Capoluongo, Ettore, de Castro, David Gonzalez, Ellison, Gillian, Endris, Volker, Friedman, Eitan, Kamel-Reid, Suzanne, Ligtenberg, Marjolijn J L, Ligtenberg, Marjolijn J.L., López-Guerrero, José Antonio, Markiefka, Birgid, Penault-Llorca, Frédérique, Percival, Natalie, Ray-Coquard, Isabelle, Röthlisberger, Benno, Schirmacher, Peter, Singer, Christian, Soong, Richie, Van Asperen, Christi J, van Asperen, Christi J.   +21 more
core   +4 more sources

Molecular basis and biological relevance of bacterial and plant pinoresinol/lariciresinol reductase specificities

Protein Science, Volume 35, Issue 2, February 2026.
Abstract A bacterial pinoresinol/lariciresinol reductase (PLR) homolog named NrPinZ was obtained from a Novosphingobium rhizosphaerae sp. LY bacterial strain, with NrPinZ being part of its 5‐step biochemical system catabolizing pinoresinol into coniferyl aldehyde and vanillin.
Clyde A. Smith, Diana L. Bedgar, Michael A. Costa, Syed G. A. Moinuddin, Marco N. Allemann, Joshua K. Michener, Laurence B. Davin, Norman G. Lewis   +7 more
wiley   +1 more source

DNA repair and synthetic lethality [PDF]

, 2011
Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR ...
Delsite, Robert, Feng, Zhi-hui, Gao, Rui-jie, Guo, Gong-she, Powell, Simon N, Zhang, Feng-mei   +5 more
core   +2 more sources

From mechanism to phenotype: What fits in a basket trial

Epilepsia, EarlyView.
Kette D. Valente
wiley   +1 more source

Molecular mechanisms of plant NLR activation and signalling

The Plant Journal, Volume 125, Issue 3, February 2026.
SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Natsumi Maruta, Mitchell Sorbello, Laura Garzon‐Flores, Bostjan Kobe   +3 more
wiley   +1 more source

Development of a selection system for the detection of L-ribose isomerase expressing mutants of Escherichia coli [PDF]

, 2007
L-Arabinose isomerase (E.C. 5.3.1.14) catalyzes the reversible isomerization between L-arabinose and L-ribulose and is highly selective towards L-arabinose.
Beauprez, Joeri, De Maeseneire, Sofie, De Mey, Marjan, De Muynck, Cassandra, Soetaert, Wim, Van Bogaert, Inge, Van der Borght, Jef, Vandamme, Erick   +7 more
core   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, Volume 46, Issue 1, Page 238-271, January 2026.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

Differential Expression of NUDT9 at Different Phases of The Menstrual Cycle and in Different Components of Normal and Neoplastic Human Endometrium

Taiwanese Journal of Obstetrics & Gynecology, 2009
Objective: The human endometrium manifests different and distinct morphologies and physiologies during the different phases of the menstrual cycle.
Ling-Yun Chen, Tze-Ho Chen, Pao-Ying Wen, Chia-Hung Chou, Tsung-Ho Ying, Shun-Ping Chang, Gwo-Chin Ma, Ming Chen   +7 more
doaj   +1 more source

Salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core