Adherens junctions remain dynamic [PDF]
BMC Biology, 2010 One of the four principal categories of cell-cell junctions that hold together and shape distinct tissues and organs in vertebrates, adherens junctions (AJs) form cell-cell contacts that connect transmembrane proteins with cytoskeletal actin filaments to
Falk Matthias M
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Syndecan-1 shedding destroys epithelial adherens junctions through STAT3 after renal ischemia/reperfusion injury [PDF]
iScience, 2023 Summary: Adherens junctions between tubular epithelial cells are disrupted in renal ischemia/reperfusion (I/R) injury. Syndecan-1 (SDC-1) is involved in maintaining cell morphology. We aimed to study the role of SDC-1 shedding induced by renal I/R in the
Man Guo +11 more
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Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination [PDF]
eLife, 2017 Detachment of newborn neurons from the neuroepithelium is required for correct neuronal architecture and functional circuitry. This process, also known as delamination, involves adherens-junction disassembly and acto-myosin-mediated abscission, during ...
Ioannis Kasioulis +2 more
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MTSS1 is downregulated in nasopharyngeal carcinoma (NPC) which disrupts adherens junctions leading to enhanced cell migration and invasion [PDF]
Frontiers in Cell and Developmental Biology, 2023 Loss of cell–cell adhesions is the indispensable first step for cancer cells to depart from the primary tumor mass to metastasize. Metastasis suppressor 1 (MTSS1) is frequently lost in metastatic tissues, correlating to advanced tumor stages and poor ...
Shixing Zheng +10 more
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IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells [PDF]
Fluids and Barriers of the CNSBackground IIIG9 was originally identified as a novel regulatory subunit of protein phosphatase 1 (PP1, PPP1R32) in ependymal cells, where it localizes to cilia and adherens junctions.
María José Oviedo +8 more
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Sensing Actin Dynamics through Adherens Junctions [PDF]
Cell Reports, 2020 Summary: We study punctate adherens junctions (pAJs) to determine how short-lived cadherin clusters and relatively stable actin bundles interact despite differences in dynamics.
Indrajyoti Indra +4 more
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HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia [PDF]
Scientific ReportsHypoxia-inducible factors (HIF) 1 and 2 regulate similar but distinct sets of target genes. Although HIFs are best known for their roles in mediating the hypoxia response accumulating evidence suggests that under certain conditions HIFs, particularly ...
I. Raykhel +3 more
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Adherens Junctions: Guardians of Cortical Development
Frontiers in Cell and Developmental Biology, 2020 Apical radial glia comprise the pseudostratified neuroepithelium lining the embryonic lateral ventricles and give rise to the extensive repertoire of pyramidal neuronal subtypes of the neocortex.
Lenin Veeraval +2 more
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Frontiers in Cell and Developmental Biology, 2021 Actomyosin contractility regulates various cellular processes including proliferation and differentiation while dysregulation of actomyosin activity contributes to cancer development and progression. Previously, we have reported that actomyosin-generated
Oleg Dobrokhotov +8 more
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