Results 31 to 40 of about 39,170 (208)
Epigenetic Regulators of White Adipocyte Browning [PDF]
Epigenomes, 2021 Adipocytes play an essential role in maintaining energy homeostasis in mammals. The primary function of white adipose tissue (WAT) is to store energy; for brown adipose tissue (BAT), primary function is to release fats in the form of heat. Dysfunctional or excess WAT can induce metabolic disorders such as dyslipidemia, obesity, and diabetes ...
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MicroRNAs in brown and white adipocytes [PDF]
The adipose tissue has an important role in maintaining the energy homeostasis balance. Understanding its physiology is important for the development of treatments against diseases where this equilibrium is compromised, such as obesity and associated metabolic disorders.
Dimitri, Federica
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iScience, 2022 Summary: The occurrence of diet-induced obesity has been increasing worldwide and has become a major health concern. Mitochondria are densely distributed in brown adipose tissue and are involved in lipid consumption.
Masakazu Fujii +8 more
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Brown adipogenic potential of brown adipocytes and peri-renal adipocytes from human embryo [PDF]
Scientific Reports, 2016 AbstractBoth brown adipocytes (BAC) and beige cells hold therapeutic potential for the treatment of metabolic disorders. Unfortunately, the amount and activity of these cells are limited in adults. Although BAC marker expression has been shown in peri-renal adipose tissues in children and adults, functional assessment is lacking.
Nan-Nan Wu +8 more
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Lipid Transport in Brown Adipocyte Thermogenesis [PDF]
Frontiers in Physiology, 2021 Non-shivering thermogenesis is an energy demanding process that primarily occurs in brown and beige adipose tissue. Beyond regulating body temperature, these thermogenic adipocytes regulate systemic glucose and lipid homeostasis. Historically, research on thermogenic adipocytes has focused on glycolytic metabolism due to the discovery of active brown ...
Gina Wade +3 more
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Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes [PDF]
Journal of Biological Chemistry, 2015 Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans and may be exploited for its anti-obesity and anti-diabetes actions. Apelin is an adipocyte-derived hormone that plays important roles in energy metabolism.
Than A. +6 more
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A Method to Induce Brown/Beige Adipocyte Differentiation from Murine Preadipocytes
Bio-Protocol, 2021 Adipocytes exhibit different morphological and functional characteristics, depending on their anatomical location, developmental origin, and stimulus. While white adipocytes tend to accumulate energy as triglycerides, brown and beige adipocytes tend to ...
Andréa Rocha +3 more
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Lithium inhibits brown adipocyte differentiation [PDF]
FEBS Letters, 2005 Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose‐dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation.
Rodrı́guez de la Concepción, Maria Luisa +4 more
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Role of Ubiquilins for Brown Adipocyte Proteostasis and Thermogenesis [PDF]
Frontiers in Endocrinology, 2021 The acclimatization of brown adipose tissue (BAT) to sustained cold exposure requires an adaptive increase in proteasomal protein quality control. Ubiquilins represent a recently identified family of shuttle proteins with versatile functions in protein degradation, such as facilitating substrate targeting and proteasomal degradation.
Carolin Muley +5 more
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The Therapeutic Potential of Brown Adipocytes in Humans [PDF]
Frontiers in Endocrinology, 2015 Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure. To date, lifestyle interventions based on reducing energy intake and/or increasing energy expenditure have proved ineffective in the prevention and/or treatment of obesity ...
Craig ePorter +6 more
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