Results 41 to 50 of about 39,170 (208)

Importance of adipocyte browning in the evolution of endothermy [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2020
Endothermy changes the relationship between organisms and their environment fundamentally, and it is therefore of major ecological and evolutionary significance. Endothermy is characterized by non-shivering thermogenesis, that is metabolic heat production in the absence of muscular activity.
Martin Jastroch, Frank Seebacher
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RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]

, 2014
Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry, Curry, Edward, Myrsini Kaforou, Cinti, S, Cinti, Saverio, Saverio Cinti, Lemonia Chatzeli, Parker, MG, Kiskinis, E, Kiskinis, Evangelos, Kaforou, M, Frontini, A, Chatzeli, Lemonia, Montana, G, Chatzeli, L, Curry, E, Kaforou, Myrsini, Evangelos Kiskinis, Montana, Giovanni, Christian, Mark, Giovanni Montana, Frontini, Andrea, Mark Christian, Parker, Malcolm G., Christian, M, Malcolm G. Parker   +25 more
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Mammalian Target of Rapamycin Signaling Pathway Regulates Mitochondrial Quality Control of Brown Adipocytes in Mice

Frontiers in Physiology, 2021
The mammalian target of rapamycin (mTOR) is an important protein kinase that senses changes in extracellular and intracellular energy levels and plays a key role in regulating energy metabolism.
Bahetiyaer Huwatibieke, Wenzhen Yin, Lingchao Liu, Yuxin Jin, Yuxin Jin, Xinxin Xiang, Xinxin Xiang, Jingyan Han, Weizhen Zhang, Yin Li, Yin Li   +10 more
doaj   +1 more source

Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine [PDF]

, 2014
Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis.
Christian, Mark, Christian, M
core   +1 more source

Loading and firing the brown adipocyte [PDF]

Adipocyte, 2017
Brown adipose tissue (BAT) is specialized to both store and expend chemical energy making it an ideal therapeutic target for various metabolic diseases. Fatty acids derived from lipid droplets within brown adipocytes acting on mitochondrial uncoupling protein 1 (UCP1) were long thought to be essential for non-shivering thermogenesis. Here, the roles of
openaire   +2 more sources

Bioactive Compounds and Adipocyte Browning Phenomenon

Current Issues in Molecular Biology, 2022
Overweight and obesity have become worldwide health issues in most countries. Current strategies aimed to prevent or reduce overweight and obesity have mainly focused on the genes and molecular mechanisms that give the functional characteristics to different types of adipose tissue.
Josué Manríquez-Núñez, Minerva Ramos-Gómez   +1 more
openaire   +3 more sources

Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes [PDF]

, 2016
Short-chain fatty acids play crucial roles in a range of physiological functions. However, the effects of short-chain fatty acids on brown adipose tissue have not been fully investigated.
GK Dimitriadis (7772033), Kyrou, Ioannis, Tan, B.K, G Tripathi (7804103), J Hu (7741025), V Patel (7804106), Patel, V., Dimitriadis, G.K, Chen, J, Dimitriadis, Georgios K., Ramanjaneya, M., Ramanjaneya, M, Tripathi, G, Tan B.K., I Kyrou (7772027), Ramanjaneya, Manjunath, James, Sean G., Tripathi, G., S James (7748780), Patel, Vanlata H., James, Sean, J Chen (80904), Hu, Jiamiao, Hu, J, Kawan, M, Hu, J., Tan, Bee K., Kawan, Mohamed, M Kawan (7804109), James, S, Tripathi, Gyanendra, Kawan, M., Kyrou, I, James, S., Randeva, Harpal S., M Ramanjaneya (7804100), Kyrou, I., Chen, J., HS Randeva (7772048), Patel, V, BK Tan (7718081), Patel, Vanlata, Dimitriadis, G.K., Randeva, H.S., Randeva, H.S, Chen, Jing   +45 more
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P2X₅ receptor is functionally expressed on mouse brown adipocyte and can be a cell surface marker [PDF]

, 2016
Brown adipocytes expressed a large variety of purinergic receptor subtypes. We investigated about the expression of P2X5 receptor subtype among purinergic receptor subtypes expressed in mouse adipose tissue.Ca2+ imaging showed that applied 10 μM ATP or 1
ハヤト, リョウタロウ, 566, HAYATO, Ryotaro, 60440822, 早戸, 亮太郎   +4 more
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Brown adipocytes promote epithelial mesenchymal transition of neuroblastoma cells by inducing PPAR-γ/UCP2 expression

Adipocyte, 2022
Neuroblastoma (NB) is an embryonic malignant tumour of the sympathetic nervous system, and current research shows that activation of brown adipose tissue accelerates cachexia in cancer patients.
Zhijuan Ge, Yue Shang, Wendie Wang, Jigang Yang, Shu-Zhen Chen   +4 more
doaj   +1 more source

The Role of Solute Carrier Transporters in Brown Adipocytes [PDF]

, 2023
Adipose tissues, including white adipose tissue (WAT) and brown adipose tissue (BAT), play a critical role in regulating insulin sensitivity and energy homeostasis, making them potential targets for clinical interventions to fight against obesity.
Sucipto, Abby Kurniawati
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