Results 61 to 70 of about 39,170 (208)

Regulatory mechanism of white adipocyte browning and research advances [PDF]

BIO Web of Conferences
Adipose tissue has energy storage and metabolic functions, and its content is highly correlated with an individual’s obesity status. The relative proportions of white adipocytes, brown adipocytes, and beige adipocytes are also important in regulating ...
Wang Zihan
doaj   +1 more source

β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes.

PLoS ONE, 2020
Boosting energy expenditure by harnessing the activity of brown adipocytes is a promising strategy for combatting the global epidemic of obesity. Many studies have revealed that the β3-adrenergic receptor agonist is a potent activator of brown adipocytes,
Kazuki Hattori, Hiroaki Wakatsuki, Chihiro Sakauchi, Shotaro Furutani, Sho Sugawara, Tomohisa Hatta, Tohru Natsume, Hidenori Ichijo   +7 more
doaj   +1 more source

L‐rhamnose induces browning in 3T3‐L1 white adipocytes and activates HIB1B brown adipocytes [PDF]

IUBMB Life, 2018
AbstractInduction of the brown adipocyte‐like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due to the ability of brown adipocytes to increase energy expenditure. Here, we report that L‐rhamnose induced browning by elevating expression levels of beige‐specific marker genes, including Cd137, Cited1, Tbx1 ...
Minji Choi, Sulagna Mukherjee, Nam Hyeon Kang, Jameel Lone Barkat, Hilal Ahmad Parray, Jong Won Yun   +5 more
openaire   +2 more sources

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes [PDF]

, 2009
MicroRNAs, a novel class of post-transcriptional gene regulators, have been demonstrated to be involved in several cellular processes regulating the expression of protein-coding genes.
Nedergaard, Jan,, Keller, P, Nedergaard, J, Timmons, James A., Nedergaard, Jan, Stockholm University, Walden, T B, Timmons, J A, Keller, Pernille, Heriot-Watt, Walden, Tomas B., Timmons, James A, Walden, Tomas B,, Cannon, Barbara,, Cannon, B, Walden, Tomas B, Cannon, Barbara   +16 more
core   +1 more source

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

Cell Reports, 2019
Summary: White adipose tissue (WAT) is a central factor in the development of type 2 diabetes, but there is a paucity of translational models to study mature adipocytes.
Matthew J. Harms, Qian Li, Sunjae Lee, Cheng Zhang, Bengt Kull, Stefan Hallen, Anders Thorell, Ida Alexandersson, Carolina E. Hagberg, Xiao-Rong Peng, Adil Mardinoglu, Kirsty L. Spalding, Jeremie Boucher   +12 more
doaj   +1 more source

PPARγ in the control of brown adipocyte differentiation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2005
The effects of fatty acids and retinoic acid (carotene) on brown adipose tissue differentiation are mediated by activation of the transcription factors PPARgamma and PPARalpha in combination with RXR. There is good support for the idea that activated PPARgamma promotes adipogenesis also in brown adipose tissue.
Nedergaard, Jan, Petrovic, Natasa, Lindgren, Eva M., Jacobsson, Anders, Cannon, Barbara   +4 more
openaire   +2 more sources

Histone acetylation modulates uncoupling protein1 expression in brown adipocytes [PDF]

, 2016
Uncoupling protein 1 (UCP1) is a classical feature of brown adipocytes and understanding its regulatory mechanism will help in the development of a pharmacological approach for obesity and associated metabolic diseases.
Rajan, Anubama
core   +2 more sources

IMPORTANCE OF IRON HOMEOSTASIS IN BEIGE AND BROWN ADIPOCYTES [PDF]

, 2021
Beige/brown adipocytes are specialized for non-shivering thermogenesis, dissipating mitochondrial energy into heat via uncoupling protein 1 (UCP1), thereby contributing to whole-body energy expenditure.
Yook, Jinseon
core   +1 more source

Difference in intracellular temperature rise between matured and precursor brown adipocytes in response to uncoupler and β-adrenergic agonist stimuli

Scientific Reports, 2017
Brown adipocytes function to maintain body temperature by heat production. However, direct measurement of heat production at a single cell level remains difficult.
Toshikazu Tsuji, Kumiko Ikado, Hideki Koizumi, Seiichi Uchiyama, Kazuaki Kajimoto   +4 more
doaj   +1 more source

Direct evidence of brown adipocytes in different fat depots in children.

PLoS ONE, 2015
Recent studies suggested the persistence of brown adipocytes in adult humans, as opposed to being exclusively present in infancy. In this study, we investigated the presence of brown-like adipocytes in adipose tissue (AT) samples of children and ...
Denise Rockstroh, Kathrin Landgraf, Isabel Viola Wagner, Julia Gesing, Roy Tauscher, Nicole Lakowa, Wieland Kiess, Ulf Bühligen, Magdalena Wojan, Holger Till, Matthias Blüher, Antje Körner   +11 more
doaj   +1 more source