PHOSPHO1 puts the breaks on thermogenesis in brown adipocytes [PDF]
Proceedings of the National Academy of Sciences, 2020 The nonshivering heat production in mitochondria-rich brown or beige adipocytes allows rodents and humans to adapt to cold stress (1). The best-characterized thermogenic effector is uncoupling protein 1 (UCP1), which dissipates energy as heat by proton transport across the mitochondrial inner membrane. Of note, there are also important UCP1-independent
Christy M. Gliniak, Philipp E. Scherer
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Brown adipocytes postnatally arise through both differentiation from progenitors and conversion from white adipocytes in Syrian hamster [PDF]
, 2018 To investigate the postnatal development of brown adipose tissue (BAT) in Syrian hamsters, we histologically examined interscapular fat tissue from 5–16-day-old pups, focusing on how brown adipocytes arise.
Junko Nio-Kobayashi +4 more
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Genetic and Functional Characterization of Novel Brown-Like Adipocytes Around the Lamprey Brain
Frontiers in Cell and Developmental Biology, 2021 During the process of vertebrate evolution, many thermogenic organs and mechanisms have appeared. Mammalian brown adipose tissue (BAT) generates heat through the uncoupling oxidative phosphorylation of mitochondria, acts as a natural defense against ...
XiaoLuan Xu +15 more
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Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice
Molecular Metabolism, 2023 Objective: Maresin 1 (MaR1) is a docosahexaenoic acid-derived proresolving lipid mediator with insulin-sensitizing and anti-steatosis properties. Here, we aim to unravel MaR1 actions on brown adipose tissue (BAT) activation and white adipose tissue (WAT)
Laura M. Laiglesia +19 more
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Brown-like adipose features within WAT in R6/2 mice. [PDF]
, 2016 A Representative images of inguinal white adipose tissue (WAT) and interscapular brown adipose tissue (iBAT) from wild type (WT) and R6/2 transgenic mice. Scale bars = 20 μm.
Andrew C. McCourt (3143664) +6 more
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5-Aza-2′-Deoxycytidine Regulates White Adipocyte Browning by Modulating miRNA-133a/Prdm16
Metabolites, 2022 The conversion of white adipocytes into brown adipocytes improves their thermogenesis and promotes energy consumption. Epigenetic modifications affect related genes and interfere with energy metabolism, and these are the basis of new ideas for obesity ...
Jia Liang +7 more
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The Mechanism of White and Brown Adipocyte Differentiation [PDF]
Diabetes & Metabolism Journal, 2013 Obesity gives vent to many diseases such as type 2 diabetes, hypertension, and hyperlipidemia, being considered as the main causes of mortality and morbidity worldwide. The pathogenesis and pathophysiology of metabolic syndrome can well be understood by studying the molecular mechanisms that control the development and function of adipose tissue.
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Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity [PDF]
Proceedings of the National Academy of Sciences, 2000 Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor α (TNF-α) in obesity is involved in functional brown fat atrophy, we have studied genetically obese ( ob / ob ) mice with targeted null ...
E, Nisoli +8 more
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Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation
Cell Reports, 2019 Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases.
Alicia Mayeuf-Louchart +20 more
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Regulation of white and brown adipocyte differentiation by RhoGAP DLC1. [PDF]
PLoS ONE, 2017 Adipose tissues constitute an important component of metabolism, the dysfunction of which can cause obesity and type II diabetes. Here we show that differentiation of white and brown adipocytes requires Deleted in Liver Cancer 1 (DLC1), a Rho GTPase ...
Choon Kiat Sim +9 more
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