mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]
, 2016 Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Handschin, Christoph +20 more
core +1 more source
A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism
Cell Reports, 2020 Summary: UCP1-dependent thermogenesis is studied to define new strategies to ameliorate obesity and type 2 diabetes; however, animal models are mostly limited to germline mutations of UCP1, which can effect adaptive changes in UCP1-independent pathways ...
Tenagne D. Challa +7 more
doaj +1 more source
Cold Exposure Induces Proliferation of Mature Brown Adipocyte in a ß3-Adrenergic Receptor-Mediated Pathway. [PDF]
PLoS ONE, 2016 Hyperplasia of brown adipose tissue (BAT) is a fundamental mechanism for adaptation to survive in the cold environment in rodents. To determine which cell types comprising BAT contribute to tissue hyperplasia, immunohistochemical analysis using a ...
Keigo Fukano +4 more
doaj +1 more source
SRF inhibits brown adipogenesis from brown pre-adipocytes. [PDF]
, 2017 (A) Cumulative distribution function (CDF) and (B) Heat Map demonstrating that mRNA expression of the targets activated by SRF is differentially regulated in brown adipose tissue stromal vascular fraction compared to mature brown adipocytes.
Lennart Opitz (86036) +3 more
core +1 more source
Shades of Brown: A Model for Thermogenic Fat
Frontiers in Endocrinology, 2015 Brown adipose tissue (BAT) is specialized to burn fuels to perform thermogenesis in defense of body temperature against cold. Recent discovery of metabolically active and relevant amounts of BAT in adult humans have made it a potentially attractive ...
Jon Michael Dempersmier, Hei Sook eSul
doaj +1 more source
Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor. [PDF]
PLoS ONE, 2017 Brown adipose tissue with its constituent brown adipocytes is a promising therapeutic target in metabolic disorders due to its ability to dissipate energy and improve systemic insulin sensitivity and glucose homeostasis.
Lasse K Markussen +8 more
doaj +1 more source
Journal of Lipid Research, 2023 Sphingosine 1-phosphate (S1P) has been implicated in brown adipose tissue (BAT) formation and energy consumption; however, the mechanistic role of sphingolipids, including S1P, in BAT remains unclear. Here, we showed that, in mice, BAT activation by cold
Jun-ichi Morishige +7 more
doaj +1 more source
Diet-Induced Adipocyte Browning
Polish Journal of Food and Nutrition Sciences, 2021 The adipocyte browning process is a phenomenon that consists in the molecular and morphological remodeling of preadipocytes or mature white adipocytes into multilocular beige fat cells expressing thermogenesis-associated genes. Adipocyte browning may occur physiologically, mainly upon cold or exercise stimulation.
Oskar Wiśniewski +3 more
openaire +2 more sources
Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis
Cell Reports, 2020 Summary: Brown adipocytes store metabolic energy as triglycerides (TGs) in lipid droplets (LDs). Fatty acids released from brown adipocyte LDs by lipolysis are thought to activate and fuel UCP1-mediated thermogenesis.
Chandramohan Chitraju +3 more
doaj +1 more source
Artepillin C, a Typical Brazilian Propolis-Derived Component, Induces Brown-Like Adipocyte Formation in C3H10T1/2 Cells, Primary Inguinal White Adipose Tissue-Derived Adipocytes, and Mice. [PDF]
PLoS ONE, 2016 Induction of brown-like adipocytes (beige/brite cells) in white adipose tissue (WAT) suggests a new approach for preventing and treating obesity via induction of thermogenesis associated with uncoupling protein 1 (UCP1).
Sho Nishikawa +9 more
doaj +1 more source