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The Adipocyte and Adaptive Immunity [PDF]
Frontiers in Immunology, 2020 Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune syndromes.
Jianfeng Song +4 more
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AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype. [PDF]
PLoS ONE, 2016 Beige adipocytes are special cells situated in the white adipose tissue. Beige adipocytes, lacking thermogenic cues, morphologically look quite similar to regular white adipocytes, but with a markedly different response to adrenalin.
Omar Abdul-Rahman +18 more
doaj +1 more source
Integrin αV Mediates the Effects of Irisin on Human Mature Adipocytes
Obesity Facts, 2022 Introdution and Aims: The myokine irisin is critical to modulating adipocytes thermogenesis and influence whole-body metabolism. However, whether there is difference in the effects of irisin on adipocytes derived from different depots remains unknown ...
Tingting Fu +6 more
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The Role of Adipocytes and Adipocyte‐Like Cells in the Severity of COVID‐19 Infections
Obesity, 2020 Coronavirus disease‐2019 (COVID‐19), caused by the highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), demonstrates high morbidity and mortality caused by development of a severe acute respiratory syndrome connected with ...
I. Kruglikov, P. Scherer
semanticscholar +1 more source
Scientific Reports, 2021 The dysfunction of adipose tissue with aging and the accumulation of senescent cells has been implicated in the pathophysiology of chronic diseases.
E. Zoico +9 more
semanticscholar +1 more source
Frontiers in Oncology, 2023 The unique properties of the bone marrow (BM) allow for migration and proliferation of multiple myeloma (MM) cells while also providing the perfect environment for development of quiescent, drug-resistant MM cell clones.
Heather Fairfield +17 more
doaj +1 more source
Current Biology, 2014 SummaryIn the United States alone, one-third of adults and nearly one-quarter of children are clinically obese. This growing epidemic is of serious concern as obesity confers a significant risk to developing numerous chronic conditions, including cancer, diabetes, and heart disease. The alarming incidence of obesity and the rising costs of treating the
openaire +2 more sources
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*)
Journal of Biological Chemistry, 1995 We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation.
P. Scherer +4 more
semanticscholar +1 more source
PPARs and adipocyte function [PDF]
Molecular and Cellular Endocrinology, 2010 For long viewed as passive lipid storage depots, adipocytes are now recognised as key players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last two decades of research have seen the emergence of transcription factors of the peroxisome proliferator-activated receptor (PPAR) family as central regulators of lipid and ...
Christodoulides, Constantinos +1 more
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UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes
Frontiers in Endocrinology, 2020 Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient ...
K. Ikeda, Tetsuya Yamada
semanticscholar +1 more source