Single Acquisition Label-free Histology-like Imaging with Dual Contrast Photoacoustic Remote Sensing Microscopy [PDF]
, 2021 Significance: Histopathological analysis of tissues is an essential tool for grading, staging, diagnosing and resecting cancers and other malignancies. Current histopathological techniques require substantial sample processing prior to staining with hematoxylin and eosin (H&E) dyes, to highlight nuclear and cellular morphology.
arxiv +1 more source
Adipocyte, 2021 Obesity is an important public-health problem worldwide. This study aimed to determine effects of porphyromonas gingivalis lipopolysaccharide (Pg-LPS) on adipocytes injuries and explore associated mechanisms. Adipocytes were isolated from SD rats.
Ying-Tao Lv +5 more
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The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes [PDF]
, 2007 Context: Obesity-associated inflammation is a contributory factor in the pathogenesis of type 2 diabetes mellitus (T2DM); the mechanisms underlying the progression to T2DM are unclear.
Adam R. Baker +45 more
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BMC Cancer, 2020 Background Cancer cells cooperate with cells that compose their environment to promote tumor growth and invasion. Among them, adipocytes provide lipids used as a source of energy by cancer cells and adipokines that contribute to tumor expansion ...
Martin Paré +10 more
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Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche
Frontiers in Oncology, 2022 Acute myeloid leukaemia (AML) is a highly proliferative cancer characterised by infiltration of immature haematopoietic cells in the bone marrow (BM). AML predominantly affects older people and outcomes, particularly in this difficult to treat population
Rebecca S. Maynard +5 more
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The Sulfonylurea Drug, Glimepiride, Stimulates Glucose Transport, Glucose Transporter Translocation, and Dephosphorylation In Insulin-Resistant Rat Adipocytes In Vitro [PDF]
, 1993 Sulfonylurea drugs are widely used in the therapy of NIDDM. The improvement of glucose tolerance after long-term treatment of NIDDM patients with the drug can be explained by stimulation of glucose utilization in peripheral tissues that are characterized
Müller, Günter, Wied, Susanne
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AMPKβ isoform expression patterns in various adipocyte models and in relation to body mass index
Frontiers in Physiology, 2022 AMP-activated protein kinase (AMPK) activation is considered a useful strategy for the treatment of type 2 diabetes (T2D). It is unclear whether the expression and/or activity of AMPK in adipocytes is dysregulated in obesity.
Franziska Kopietz +2 more
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Theoretical Model and Characteristics of Mitochondrial Thermogenesis [PDF]
Biophysics Reports 2018, 2017 Mitochondria of brown adipocyte (BA) are the main intracellular sites for thermogenesis, which have been targeted for therapy to reduce obesity. However, there are long-standing critique and debates about the ability of raising cellular temperature by endogenous thermogenesis.
arxiv +1 more source
Regulatory mechanism of white adipocyte browning and research advances [PDF]
BIO Web of ConferencesAdipose tissue has energy storage and metabolic functions, and its content is highly correlated with an individual’s obesity status. The relative proportions of white adipocytes, brown adipocytes, and beige adipocytes are also important in regulating ...
Wang Zihan
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UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes
Frontiers in Endocrinology, 2020 Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient ...
Kenji Ikeda, Tetsuya Yamada
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