Results 31 to 40 of about 173,125 (313)

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

Cell Reports, 2019
Summary: White adipose tissue (WAT) is a central factor in the development of type 2 diabetes, but there is a paucity of translational models to study mature adipocytes.
Matthew J. Harms, Qian Li, Sunjae Lee, Cheng Zhang, Bengt Kull, Stefan Hallen, Anders Thorell, Ida Alexandersson, Carolina E. Hagberg, Xiao-Rong Peng, Adil Mardinoglu, Kirsty L. Spalding, Jeremie Boucher   +12 more
doaj   +1 more source

Development and characterization of three cell culture systems to investigate the relationship between primary bone marrow adipocytes and myeloma cells

Frontiers in Oncology, 2023
The unique properties of the bone marrow (BM) allow for migration and proliferation of multiple myeloma (MM) cells while also providing the perfect environment for development of quiescent, drug-resistant MM cell clones.
Heather Fairfield, Heather Fairfield, Heather Fairfield, Rebecca Condruti, Mariah Farrell, Mariah Farrell, Mariah Farrell, Reagan Di Iorio, Reagan Di Iorio, Carlos A. Gartner, Carlos A. Gartner, Carlos A. Gartner, Calvin Vary, Calvin Vary, Calvin Vary, Michaela R. Reagan, Michaela R. Reagan, Michaela R. Reagan   +17 more
doaj   +1 more source

The Effects of Adipocytes on the Regulation of Breast Cancer in the Tumor Microenvironment: An Update

Cells, 2019
Obesity is a global pandemic and it is well evident that obesity is associated with the development of many disorders including many cancer types. Breast cancer is one of that associated with a high mortality rate.
Dinh-Toi Chu, Thuy Nguyen Thi Phuong, Nguyen Le Bao Tien, Dang-Khoa Tran, Tran-Thuy Nguyen, Vo Van Thanh, Thuy Luu Quang, Le Bui Minh, Van Huy Pham, Vo Truong Nhu Ngoc, Kushi Kushekhar, Thien Chu-Dinh   +11 more
doaj   +1 more source

Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche

Frontiers in Oncology, 2022
Acute myeloid leukaemia (AML) is a highly proliferative cancer characterised by infiltration of immature haematopoietic cells in the bone marrow (BM). AML predominantly affects older people and outcomes, particularly in this difficult to treat population
Rebecca S. Maynard, Charlotte Hellmich, Charlotte Hellmich, Kristian M. Bowles, Kristian M. Bowles, Stuart A. Rushworth   +5 more
doaj   +1 more source

Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses

Mediators of Inflammation, 2017
Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages.
Louisa Dowal, Pooja Parameswaran, Sarah Phat, Syamala Akella, Ishita Deb Majumdar, Jyoti Ranjan, Chahan Shah, Saie Mogre, Kalyani Guntur, Khampaseuth Thapa, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Rangaprasad Sarangarajan   +13 more
doaj   +1 more source

INSULIN AND LEPTIN: DISPUTABLE AND UNSOLVED QUESTIONS OF THEIR INTERACTION

Атеросклероз, 2019
Leptin and its receptor are widely distributed mainly in white adipose tissue. Serum leptin concentration correlates with body mass index, and its levels decrease with fasting.
E. V. Belik, O. V. Gruzdeva, E. I. Palicheva   +2 more
doaj   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Exosomal linc-ROR mediates crosstalk between cancer cells and adipocytes to promote tumor growth in pancreatic cancer

Molecular Therapy: Nucleic Acids, 2021
Exosomes are emerging as important mediators of the crosstalk between tumor cells and stromal cells in the microenvironment. However, the underlying molecular mechanism of pancreatic cancer (PC)-derived exosomes in the progression of the tumor ...
Zhaowei Sun, Dong Sun, Yujie Feng, Bingyuan Zhang, Peng Sun, Bin Zhou, Lutao Du, Yunshan Wang, Zhiyao Fan, Jian Yang, Yongzheng Li, Sanyuan Hu, Hanxiang Zhan   +12 more
doaj   +1 more source

Brown Adipocyte Focus [PDF]

Cell Metabolism, 2010
We are pleased to present in this issue of Cell Metabolism a review series on brown adipocytes. Until recently, brown adipose tissue (BAT) was principally studied by a handful of investigators focused on rodents and newborn mammals, and, at times, their work was deemed more an exercise in scientific curiosity than an issue relevant to human health.
Emambokus, Nikla, Wang, Charlotte
openaire   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source