Transformed epithelia trigger non-tissue-autonomous tumor suppressor response by adipocytes via activation of toll and Eiger/TNF signaling [PDF]
, 2014 High tumor burden is associated with increased levels of circulating inflammatory cytokines that influence the pathophysiology of the tumor and its environment.
Parisi, Federica +4 more
core +2 more sources
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis
Molecular Metabolism, 2021 Objective: Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a key feature of adipose dysfunction and inflammation.
Francisco Javier Ruiz-Ojeda +15 more
doaj
Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. [PDF]
, 2016 Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity.
Bakirtzi, K +25 more
core +1 more source
PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes
Molecular Metabolism, 2022 Objective: Brown adipocytes play a key role in maintaining body temperature as well as glucose and lipid homeostasis. However, brown adipocytes need to adapt their thermogenic activity and substrate utilization to changes in nutrient availability ...
Jiefu Wang +9 more
doaj
Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in FABP4 induction [PDF]
, 2020 Adipocyte differentiation of bovine adipose-derived stem cells (ASC) was induced by foetal bovine serum (FBS), biotin, pantothenic acid, insulin, rosiglitazone, dexamethasone and 3-isobutyl-1-methylxanthine, followed by incubation in different media to ...
Aschenbach, Jörg R. +6 more
core +1 more source
Frontiers in Immunology, 2019 This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial and subcutaneous adipose tissues in interconnection with the visceral adipose tissue area and the biochemical and clinical characteristics of patients with ...
Olga Gruzdeva +20 more
doaj +1 more source
Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]
, 2018 Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core +2 more sources
Hypoxia-driven metabolic reprogramming of adipocytes fuels cancer cell proliferation
Frontiers in Endocrinology, 2022 ObjectiveObesity increases the risk of certain cancers, especially tumours that reside close to adipose tissue (breast and ovarian metastasis in the omentum).
R. Aird +8 more
doaj +1 more source
Numerical analysis of a mechanotransduction dynamical model reveals homoclinic bifurcations of extracellular matrix mediated oscillations of the mesenchymal stem cell fate [PDF]
International Journal of Non-Linear Mechanics, 113, 146-157, 2019, 2019 We perform one and two-parameter numerical bifurcation analysis of a mechanotransduction model approximating the dynamics of mesenchymal stem cell differentiation into neurons, adipocytes, myocytes and osteoblasts. For our analysis, we use as bifurcation parameters the stiffness of the extracellular matrix and parameters linked with the positive ...
arxiv +1 more source
Androstenedione changes steroidogenic activity of SGBS cells
Endocrine Connections, 2020 The rapid increase of obesity during the last decades and its future prospects are alarming. Besides the general discussed causes of obesity, the ‘Developmental Origins of Health and Disease’ (DOHaD) hypothesis received more attention in recent years ...
Jana Ernst +6 more
doaj +1 more source