Results 71 to 80 of about 339,181 (407)

Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway

Stem cell research & therapeutics, 2019
Although adipocytes are the most abundant stromal cell component in breast cancer tissues, their interaction with breast cancer cells has been less investigated compared to cancer-associated fibroblasts or macrophages.
Shihua Wang, Xiaodong Su, Meiqian Xu, Xian Xiao, Xiaoxia Li, Hongling Li, A. Keating, R. Zhao   +7 more
semanticscholar   +1 more source

Adipocytes contribute to tumor progression and invasion of peritoneal metastasis by interacting with gastric cancer cells as cancer associated fibroblasts

Cancer Reports, 2023
Background Peritoneal metastasis (PM) is one of the most common causes of noncurative surgery and the most frequent recurrence pattern in gastric cancer (GC).
Toshihide Hamabe‐Horiike, Shin‐ichi Harada, Kyoko Yoshida, Jun Kinoshita, Takahisa Yamaguchi, Sachio Fushida   +5 more
doaj   +1 more source

MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration

Frontiers in Endocrinology, 2021
Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and excessive accumulation of dysfunctional PVAT are hallmarks of pathogenesis after angioplasty.
Yu Lei, Yu Lei, Yu Lei, Jianfei Xu, Mengju Li, Ting Meng, Meihua Chen, Yongfeng Yang, Hongda Li, Tao Zhuang, Tao Zhuang, Junli Zuo   +11 more
doaj   +1 more source

Computational modeling of the physical features that influence breast cancer invasion into adipose tissue [PDF]

APL Bioengineering 8 (2024) 036104
Breast cancer invasion into adipose tissue strongly influences disease progression and metastasis. The degree of cancer cell invasion into adipose tissue depends on numerous biochemical and physical properties of cancer cells, adipocytes, and other key components of adipose tissue.
arxiv   +1 more source

Evidence of mature adipocyte proliferation regulated by proliferin [PDF]

, 2010
Despite much research, whether mature adipocytes proliferate remains controversial. Here, we examined 5-bromo-2′-deoxyuridine (BrdU)-labelling of mature adipocytes.
Aki Minami, Hideyuki Okada, Hiroyuki Morita, Ichiro Mori, Isao Nagano, Kazuo Kajita, Kei Fujioka, Masahiro Yamauchi, Masao Takemura, Mitsuru Seishima, Takahide Ikeda, Takayuki Hanamoto, Tatsuo Ishizuka, Toshiko Kajita, Wu Zhiliang, Yoshihiro Uno, Yuzo Takahashi   +16 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Ceramides in Adipose Tissue

Frontiers in Endocrinology, 2020
Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and consumption. Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy ...
Ying Li, Chad Lamar Talbot, Bhagirath Chaurasia, Bhagirath Chaurasia   +3 more
doaj   +1 more source

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.

JCI Insight, 2017
In breast cancer, a key feature of peritumoral adipocytes is their loss of lipid content observed both in vitro and in human tumors. The free fatty acids (FFAs), released by adipocytes after lipolysis induced by tumor secretions, are transferred and ...
Y. Wang, C. Attané, D. Milhas, B. Dirat, S. Dauvillier, Adrien Guérard, J. Gilhodes, I. Lazar, N. Alet, Victor Laurent, S. Le Gonidec, D. Biard, C. Hervé, F. Bost, G. Ren, F. Bono, G. Escourrou, M. Prentki, Laurence Nieto, P. Valet, C. Muller   +20 more
semanticscholar   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis [PDF]

, 2012
Peer reviewedPublisher ...
A Agouni, A Katsuki, A Moody, Abdelali Agouni, AD Kohn, Alicja Czopek, Andy Welch, AR Saltiel, BA Zinker, Barbara B. Kahn, BB Kahn, Benjamin G. Neel, BS Hamilton, C Pérez, Carl Owen, CL Venable, CM Rondinone, CM Taniguchi, DD Sarbassov, ED Rosen, Emma K. Lees, F Lönnqvist, G Arya, George D. Mcilroy, GI Shulman, J Dorrestijn, J Eguchi, J Fine, J Foley, J Mao, JD Horton, JF Waring, JV Frangioni, K Almind, K Bence, K Kobayashi, K Loh, K Matsuo, KA Kenner, Kendra K. Bence, KK Bence, LD Klaman, Louise Grant, M Delibegovic, M Delibegovic, M Elchebly, MA Herman, Maria Eugenia Saez, Mirela Delibegović, MY Wang, N Halberg, N Suwaki, Nimesh Mody, Olga Göransson, PE Scherer, R Banno, R Unger, Robert Judson, S Biddinger, S Franckhauser, S Galic, S Kersten, S Miranda, S Shimizu, SC Ruffolo, SC Yip, TA Woodford-Thomas, VS Muthusamy, Y Bai, Y Wang, ZV Wang   +70 more
core   +7 more sources