Results 91 to 100 of about 15,625 (221)

Metabolic programming of a beige adipocyte phenotype by genistein [PDF]

, 2017
Scope Promoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice.
Anupongsanugool, Barbatelli, Couteur, der Lans, Elabd, Green, Green, Hargreaves, Harms, Himms-Hagen, Ions, Kamiya, Kim, Kim, King, Lee, Lephart, Luo, Matsushita, Moisan, Niculescu, Ozasa, Penza, Prossnitz, Qiang, Rannikko, Sanchez-Gurmaches, Sanchez-Gurmaches, Seale, Seale, Takahashi, Torre-Villalvazo, Vitali, Wakeling, Wang, Wu, Xie, Yoneshiro, Zhang   +38 more
core   +1 more source

Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Stem cells offer multifaceted therapeutic approaches for inflammatory diseases, each exhibiting distinct therapeutic properties. Hematopoietic stem cells, primarily through hematopoietic stem cell transplantation (HSCT), can effectively remodel the immune environment, showing particular promise in treating genetically linked cases.
Chen Wu, Zhi‐Ping Jin, Shu‐Qiang Weng, Ji‐Min Zhu, Ling Dong   +4 more
wiley   +1 more source

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

Cell Reports, 2013
The phenomenon of white fat "browning," in which certain white adipose tissue depots significantly increase gene expression for the uncoupling protein UCP1 and thus supposedly acquire thermogenic, fat-burning properties, has attracted considerable attention.
Irina G. Shabalina, Natasa Petrovic, Jasper M.A. de Jong, Anastasia V. Kalinovich, Barbara Cannon, Jan Nedergaard   +5 more
openaire   +3 more sources

Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes

Frontiers in Endocrinology, 2020
Brown adipose tissue (BAT) and beige adipose tissue dissipate metabolic energy and mediate nonshivering thermogenesis, thereby boosting energy expenditure. Increasing the browning of BAT and beige adipose tissue is expected to be a promising strategy for
Ya-Nan Duan, Ya-Nan Duan, Xiang Ge, Hao-Wen Jiang, Hong-Jie Zhang, Yu Zhao, Jin-Long Li, Jin-Long Li, Wei Zhang, Jing-Ya Li   +9 more
doaj   +1 more source

Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. [PDF]

, 2020
Cold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure.
Ferro, Marc D, Ikeda, Kenji, Kajimura, Shingo, Oguri, Yasuo, Poon, Ada SY, Tajima, Kazuki, Tanabe, Yuji, Thomson, Ella A, Yoneshiro, Takeshi   +8 more
core  

Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma [PDF]

, 2016
Context: Patients with pheochromocytoma (pheo) show presence of multilocular adipocytes that express uncoupling protein (UCP) 1 within periadrenal (pADR) and omental (OME) fat depots. It has been hypothesized that this is due to adrenergic stimulation
Avital Harari, Betz, Bordicchia, Cannon, Chondronikola, Cypess, Cypess, Cypess, de Jong, Di Franco, Frontini, Giordano, Graeme R. Davies, Harold S. Sacks, Himms-Hagen, Hondares, Huang, Jason Y. Lin, Jespersen, Kajimura, Karen Reue, Kern, Laurent Vergnes, Leibel, Lidell, Masha J. Livhits, Michael E. Symonds, Michael W. Yeh, Nagano, Nedergaard, Patsouris, Petrovic, Plouin, Rogers, Sacks, Seale, Sharp, Shinoda, Sidossis, Stepniakowski, Strack, Svensson, Søndergaard, Ussar, van der Lans, van Marken Lichtenbelt, Virtanen, Waldén, Wu   +48 more
core   +1 more source

Acyl‐CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Acyl‐CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long‐chain acyl‐CoAs. We generated an adipocyte‐wide ACBP knockout mouse and a brown adipose tissue‐specific ACBP knockout mouse to investigate ACBP function in adipose tissue.
M. F. Nørremark, R. Petersen, P. M. M. Ruppert, E. S. Jul, T. K. Doktor, R. Nielsen, J. F. Kappel, S. Larsen, J. W. Kornfeld, S. Mandrup, B. S. Andresen, J. Havelund, D. Neess, N. J. Færgeman   +13 more
wiley   +1 more source

Metabolic heterogeneity of activated beige/brite adipocytes in inguinal adipose tissue [PDF]

Scientific Reports, 2017
AbstractSustained β3 adrenergic receptor (ADRB3) activation simultaneously upregulates fatty acid synthesis and oxidation in mouse brown, beige, and white adipose tissues; however, the cellular basis of this dual regulation is not known. Treatment of mice with the ADRB3 agonist CL316,243 (CL) increased expression of fatty acid synthase (FASN) and ...
Yun-Hee Lee, Sang-Nam Kim, Hyun-Jung Kwon, James G. Granneman   +3 more
openaire   +2 more sources

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance

Molecular Metabolism, 2016
Objective: Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism.
Marina T. DiStefano, Rachel J. Roth Flach, Ozlem Senol-Cosar, Laura V. Danai, Joseph V. Virbasius, Sarah M. Nicoloro, Juerg Straubhaar, Sezin Dagdeviren, Martin Wabitsch, Olga T. Gupta, Jason K. Kim, Michael P. Czech   +11 more
doaj   +1 more source

Characterization of cold-induced remodelling reveals depot-specific differences across and within brown and white adipose tissues in mice [PDF]

, 2016
Brown and beige adipose tissues dissipate energy in the form of heat via mitochondrial uncoupling protein 1, defending against hypothermia and potentially obesity.
Atit, Aydin, Barbatelli, Barneda, Barnett, Bordicchia, Bostrom, Bukowiecki, Cannon, Cannon, Cao, Cederberg, Cinti, Cousin, Dallner, Fisher, Gautier, Gesta, Giannulis, Ishibashi, Jacobsson, Jakus, Lee, Lee, Lee, Lee, Lee, Lepper, Nakamura, Nedergaard, Nedergaard, Petrovic, Ravussin, Robidoux, Sanchez-Gurmaches, Sanchez-Gurmaches, Schulz, Seale, Seale, Shefer, Shore, Stephens, Timmons, Ukropec, Vaanholt, Vernochet, Virtue, Vitali, Waldén, Wang, Widberg, Xue, Yoo, Yu, Yu, Zhou   +55 more
core   +1 more source