Results 21 to 30 of about 1,797,998 (215)

Matrix-Assisted Transplantation of Functional Beige Adipose Tissue [PDF]

Diabetes, 2015
Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitochondrial respiration from ATP synthesis.
Tharp, Kevin M, Jha, Amit K, Kraiczy, Judith, Yesian, Alexandra, Karateev, Grigory, Sinisi, Riccardo, Dubikovskaya, Elena A, Healy, Kevin E, Stahl, Andreas   +8 more
openaire   +6 more sources

“Beige” Cross Talk Between the Immune System and Metabolism

Frontiers in Endocrinology, 2019
With thymic senescence the epithelial network shrinks to be replaced by adipose tissue. Transcription factor TBX-1 controls thymus organogenesis, however, the same TBX-1 has also been reported to orchestrate beige adipose tissue development.
Krisztina Banfai, Krisztina Banfai, David Ernszt, David Ernszt, Attila Pap, Peter Bai, Peter Bai, Peter Bai, Peter Bai, Kitti Garai, Kitti Garai, Djeda Belharazem, Judit E. Pongracz, Judit E. Pongracz, Krisztian Kvell, Krisztian Kvell   +15 more
doaj   +1 more source

Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation

Frontiers in Cell and Developmental Biology, 2020
Adipose progenitor cells, or preadipocytes, constitute a small population of immature cells within the adipose tissue. They are a heterogeneous group of cells, in which different subtypes have a varying degree of commitment toward diverse cell fates ...
Iryna Pyrina, Kyoung-Jin Chung, Zoi Michailidou, Michael Koutsilieris, Triantafyllos Chavakis, Triantafyllos Chavakis, Triantafyllos Chavakis, Antonios Chatzigeorgiou, Antonios Chatzigeorgiou   +8 more
doaj   +1 more source

Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine [PDF]

, 2014
Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis.
Christian, Mark, Christian, M
core   +1 more source

Adipose-derived mesenchymal stromal/stem cells : tissue localization, characterization, and heterogeneity [PDF]

, 2012
Adipose tissue as a stem cell source is ubiquitously available and has several advantages compared to other sources. It is easily accessible in large quantities with minimal invasive harvesting procedure, and isolation of adipose-derived mesenchymal ...
Helmut Geiger, Geiger, Helmut, Baer, Patrick C., Patrick C. Baer   +3 more
core   +1 more source

Pioglitazone does not synergize with mirabegron to increase beige fat or further improve glucose metabolism

JCI Insight, 2021
BACKGROUND Beige and brown adipose tissue (BAT) are associated with improved metabolic homeostasis. We recently reported that the β3-adrenergic receptor agonist mirabegron induced beige adipose tissue in obese insulin-resistant subjects, and this was ...
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, Philip A. Kern   +12 more
doaj   +1 more source

Thermogenic adipose tissue aging: Mechanisms and implications

Frontiers in Cell and Developmental Biology, 2022
Adipose tissue undergoes significant anatomical and functional changes with aging, leading to an increased risk of metabolic diseases. Age-related changes in adipose tissue include overall defective adipogenesis, dysfunctional adipokine secretion ...
Graciano da Nadyellem Silva, Angelica Amorim Amato   +1 more
doaj   +1 more source

MicroRNA-33 Inhibits Adaptive Thermogenesis and Adipose Tissue Beiging [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2021
Objective: Recent studies have identified key transcriptional regulators of brown adipose tissue (BAT) differentiation and function, but posttranscriptional control of this network by microRNAs remains incompletely understood.
Milessa Silva Afonso, Narendra Verma, Coen van Solingen, Yannick Cyr, Monika Sharma, Luce Perie, Emma M. Corr, Martin Schlegel, Lianne C. Shanley, Daniel Peled, Jenny Y. Yoo, Ann Marie Schmidt, Elisabetta Mueller, Kathryn J. Moore   +13 more
openaire   +2 more sources

FBF1 Deficiency Promotes Beiging and Healthy Expansion of White Adipose Tissue [PDF]

SSRN Electronic Journal, 2021
Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential player in controlling selective cilia import.
Zhang, Yingyi, Hao, Jielu, Tarrago, Mariana G., Warner, Gina M., Giorgadze, Nino, Wei, Qing, Huang, Yan, He, Kai, Chen, Chuan, Peclat, Thais R., White, Thomas A., Ling, Kun, Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N., Hu, Jinghua   +15 more
openaire   +2 more sources

Brown and Beige Fat: Therapeutic Potential in Obesity

Indonesian Biomedical Journal, 2014
BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
doaj   +1 more source