Results 41 to 50 of about 1,797,998 (215)

The role of brown and beige adipose tissue in glycaemic control

Molecular Aspects of Medicine, 2019
For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting the so-called batokines to ...
Klepac, K., Georgiadi, A., Tschöp, M.H., Herzig, S.   +3 more
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Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations [PDF]

Diabetes, 2015
Regular physical activity and exercise training have long been known to cause adaptations to white adipose tissue (WAT), including decreases in cell size and lipid content and increases in mitochondrial proteins. In this article, we discuss recent studies that have investigated the effects of exercise training on mitochondrial function, the “beiging ...
Stanford, Kristin I., Middelbeek, Roeland J.W., Goodyear, Laurie J.   +2 more
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mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]

, 2016
Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Handschin, Christoph, Mitsugu Shimobayashi, Svensson, Kristoffer, Shimobayashi, Mitsugu, Muñoz, Sergio, Hall, Michael N., Verena Albert, Michael N Hall, Fatima Bosch, Albert, Verena, Kristoffer Svensson, Sergio Muñoz, Christoph Handschin, Bosch i Tubert, Fàtima, Colombi, Marco, Marco Colombi, Bosch, Fatima, Veronica Jimenez, Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG), Muñoz-Martínez, S, Jimenez, Veronica   +20 more
core   +1 more source

Beta‐adrenergic agonist induces unique transcriptomic signature in inguinal white adipose tissue

Physiological Reports, 2023
Activation of thermogenic adipose tissue depots has been linked to improved metabolism and weight loss. To study the molecular regulation of adipocyte thermogenesis, we performed RNA‐Seq on brown adipose tissue (BAT), gonadal white adipose tissue (gWAT),
Henry A. Paz, Anna‐Claire Pilkington, Hannah D. Loy, Ying Zhong, Kartik Shankar, Umesh D. Wankhade   +5 more
doaj   +1 more source

Brown and beige adipose tissues

Journal of Applied Physiology, 2018
With the recent rediscovery of brown fat in adult humans, our outlook on adipose tissue biology has undergone a paradigm shift. While we attempt to identify, recruit, and activate classic brown fat stores in humans, identification of beige fat has also raised the possibility of browning our white fat stores.
Chechi, Kanta, van Marken Lichtenbelt, Wouter, Richard, Denis   +2 more
openaire   +1 more source

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton [PDF]

Endocrinology, 2013
Abstract It is known that insulin resistance and type 2 diabetes mellitus are associated with increased fractures and that brown adipose tissue (BAT) counteracts many if not all of the symptoms associated with type 2 diabetes. By the use of FoxC2AD+/Tg mice, a well-established model for induction of BAT, or beige fat, we present data ...
Sima, Rahman, Yalin, Lu, Piotr J, Czernik, Clifford J, Rosen, Sven, Enerback, Beata, Lecka-Czernik   +5 more
openaire   +2 more sources

Current Progress in Adipose Tissue Biology: Implications in Obesity and Its Comorbidities

Indonesian Biomedical Journal, 2020
BACKGROUND: Obesity has been decades become a highly interest study, accompanied by the realization that adipose tissue (AT) plays a major role in the regulation of metabolic function.
Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya   +2 more
doaj   +1 more source

Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT

Molecular Metabolism, 2023
Objective: Cold stimuli trigger the conversion of white adipose tissue into beige adipose tissue, which is capable of non-shivering thermogenesis. However, what process drives this activation of thermogenesis in beige fat is not well understood. Here, we
Kyung-Mi Choi, Christopher Y. Ko, Sung-Min An, Seung-Hee Cho, Douglas J. Rowland, Jung Hak Kim, Anna Fasoli, Abhijit J. Chaudhari, Donald M. Bers, John C. Yoon   +9 more
doaj   +1 more source

Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis

Genes and Diseases, 2022
Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure, ultimately reducing adiposity.
Chun Xing, Duo Jiang, Yang Liu, Qiqun Tang, Haiyan Huang   +4 more
doaj   +1 more source

Role of glucocorticoid receptor (GR) in white adipose tissue beiging

Life Sciences, 2023
Glucocorticoids (GCs) play a crucial role in energy homeostasis including white adipose tissue function; however, chronic GC excess is detrimental to mammals' health. White hypertrophic adiposity is a main factor for neuroendocrine-metabolic dysfunctions in monosodium L-glutamate (MSG)-damaged hypercorticosteronemic rat.
Martín, Florencia M., Alzamendi, Ana, Harnichar, Alejandro Ezequiel, Castrogiovanni, Daniel Cayetano, Zubiría, María Guillermina, Spinedi, Eduardo Julio, Giovambattista, Andrés   +6 more
openaire   +4 more sources