Results 91 to 100 of about 4,726 (204)

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Allergy, Volume 79, Issue 5, Page 1089-1122, May 2024.
Abstract The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferation, differentiation, and activation.
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. C. A. M. Van Esch, C. Stellato   +19 more
wiley   +1 more source

The two-pore channel TPCN2 mediates NAADP-dependent Ca-release from lysosomal stores [PDF]

, 2009
Second messenger-induced Ca2+-release from intracellular stores plays a key role in a multitude of physiological processes. In addition to 1,4,5-inositol trisphosphate (IP3), Ca2+, and cyclic ADP ribose (cADPR) that trigger Ca2+-release from the ...
Xiangang Zong, Michael Schieder, Hartmut Cuny, Stefanie Fenske, Christian Gruner, Katrin Rötzer, Oliver Griesbeck, Hartmann Harz, Martin Biel, Christian Wahl-Schott, A Beck, G Berridge, MJ Berridge, FX Boittin, EJ Bowman, LM Broad, PJ Calcraft, JM Cancela, D Churamani, GC Churchill, DE Clapham, DE Clapham, A Galione, A Galione, JV Gerasimenko, G Grynkiewicz, AH Guse, K Ishibashi, HC Lee, HC Lee, F Malavasi, R Masgrau, K Mikoshiba, AJ Morgan, B Much, E Peiter, BC Schroeder, M Steen, H Streb, C Wahl-Schott, FH Yu, R Zalk, N Zerangue   +42 more
core   +1 more source

Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. III. Skeletal Integrity [PDF]

, 2007
Two unique chicken F2 populations generated from a broiler breeder male line and 2 genetically distinct inbred (\u3e99%) chicken lines (Leghorn and Fayoumi) were used for whole genome QTL analysis.
Ashwell, C. M., Deeb, Nader, Evock-Clover, C. M., Lamont, Susan, Lamont, Susan, Mitchell, A. D., Zhou, H.   +6 more
core   +3 more sources

Specificity of cholera toxin and mono(ADP-ribosyl)transferase activity in cultured myoblasts [PDF]

, 1990
The relationship between ADP-ribosylation and phosphorylation using a model substrate, the specificity requirements for cholera toxin-catalyzed ADP-ribosylation using peptide substrates, and the role of ADP-ribosylation reactions in skeletal muscle were ...
Kharadia, Shanta Virabhai
core   +3 more sources

The hidden life of NAD+-consuming ectoenzymes in the endocrine system [PDF]

, 2010
Ectoenzymes are a family of cell surface molecules whose catalytic domain lies in the extracellular region. A subset of this family, nucleotide-metabolizing ectoenzymes, are key components in the regulation of the extracellular balance between ...
AUDRITO, VALENTINA, Chillemi A, DEAGLIO, Silvia, GANDIONE, Marina, HORENSTEIN, ALBERTO, MALAVASI, Fabio, SERRA, SARA, TIZZANI, Alessandro, ZACCARELLO, GIANLUCA, ZITELLA, Andrea   +9 more
core   +1 more source

"Your funeral... my trial": a review of the mechanisms leading to cancer cells death when targeting nicotinamide adenine dinucleotide [PDF]

, 2014
Le nicotinamide adénine dinucléotide (NAD) est un métabolite jouant un rôle crucial dans la vie cellulaire. Dans la mitochondrie, il est surtout utilisé comme co-enzyme d'oxydo-réduction afin de produire de l'énergie sous forme d'ATP (respiration ...
MORISOD, L.
core  

Phosphodiesterase inhibition induces retinal degeneration, oxidative stress and inflammation in cone-enriched cultures of porcine retina. [PDF]

, 2013
nherited retinal degenerations affecting both rod and cone photoreceptors constitute one of the causes 74 of incurable blindness in the developed world. Cyclic guanosine monophosphate (cGMP) is crucial in the 75 phototransduction and, mutations in genes ...
Aller Mañas, Elena, García Tárraga, Patricia, García Verdugo, José Manuel, Gómez Pinedo, Ulises, Jaijo, Teresa, Martínez Fernández de la Cámara, Cristina, Millán Salvador, José María, Rodrigo, Regina, Sequedo, María Dolores   +8 more
core   +2 more sources

ANTI-CD38 MONOCLONAL ANTIBODIES: TRANSFORMING MULTIPLE MYELOMA TREATMENT

Hematology, Transfusion and Cell Therapy
Introduction: Multiple myeloma (MM) is a neoplasm defined by the clonal proliferation of malignant plasma cells (PC) within the bone marrow (BM).
Cem Selim
doaj   +1 more source

Crystal structure of ADP-ribosyl cyclase [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 1996
C. D. Stout, G. Sridhar Prasad, E. A. Stura, D. E. McRee, D. G. Levitt, H. C. Lee   +5 more
openaire   +1 more source

CD38 as theranostic target in oncology

Journal of Translational Medicine
CD38 is a multifunctional transmembrane glycoprotein found in multiple tissues and overexpressed in many cancer cells, notably in hematological malignancies such as leukemia and multiple myeloma (MM).
Valentina Bocuzzi, Jessica Bridoux, Michelle Pirotte, Nadia Withofs, Roland Hustinx, Matthias D’Huyvetter, Jo Caers, Guillaume Marcion   +7 more
doaj   +1 more source