Results 91 to 100 of about 4,754 (181)

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Allergy, Volume 79, Issue 5, Page 1089-1122, May 2024.
Abstract The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferation, differentiation, and activation.
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. C. A. M. Van Esch, C. Stellato   +19 more
wiley   +1 more source

Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]

, 2016
Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E., Farquharson, Andrew J., Horgan, Graham W, Williams, Lynda M.   +3 more
core   +1 more source

NAD metabolism: Role in senescence regulation and aging

Aging Cell, Volume 23, Issue 1, January 2024.
The biological impact of NAD boosting on aging and cellular senescence is not completely understood. It appears that NAD is necessary for senescent cell function. Therefore, NAD boosting may increase senescence‐induced dysfunction. Combination of NAD boosters with senolytic therapy may be a promising approach to improve NAD‐targeted interventions ...
Claudia Christiano Silva Chini, Heidi Soares Cordeiro, Ngan Le Kim Tran, Eduardo Nunes Chini   +3 more
wiley   +1 more source

Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. III. Skeletal Integrity [PDF]

, 2007
Two unique chicken F2 populations generated from a broiler breeder male line and 2 genetically distinct inbred (\u3e99%) chicken lines (Leghorn and Fayoumi) were used for whole genome QTL analysis.
Ashwell, C. M., Deeb, Nader, Evock-Clover, C. M., Lamont, Susan, Lamont, Susan, Mitchell, A. D., Zhou, H.   +6 more
core   +3 more sources

Specificity of cholera toxin and mono(ADP-ribosyl)transferase activity in cultured myoblasts [PDF]

, 1990
The relationship between ADP-ribosylation and phosphorylation using a model substrate, the specificity requirements for cholera toxin-catalyzed ADP-ribosylation using peptide substrates, and the role of ADP-ribosylation reactions in skeletal muscle were ...
Kharadia, Shanta Virabhai
core   +3 more sources

The hidden life of NAD+-consuming ectoenzymes in the endocrine system [PDF]

, 2010
Ectoenzymes are a family of cell surface molecules whose catalytic domain lies in the extracellular region. A subset of this family, nucleotide-metabolizing ectoenzymes, are key components in the regulation of the extracellular balance between ...
AUDRITO, VALENTINA, Chillemi A, DEAGLIO, Silvia, GANDIONE, Marina, HORENSTEIN, ALBERTO, MALAVASI, Fabio, SERRA, SARA, TIZZANI, Alessandro, ZACCARELLO, GIANLUCA, ZITELLA, Andrea   +9 more
core   +1 more source

ANTI-CD38 MONOCLONAL ANTIBODIES: TRANSFORMING MULTIPLE MYELOMA TREATMENT

Hematology, Transfusion and Cell Therapy
Introduction: Multiple myeloma (MM) is a neoplasm defined by the clonal proliferation of malignant plasma cells (PC) within the bone marrow (BM).
Cem Selim
doaj   +1 more source

"Your funeral... my trial": a review of the mechanisms leading to cancer cells death when targeting nicotinamide adenine dinucleotide [PDF]

, 2014
Le nicotinamide adénine dinucléotide (NAD) est un métabolite jouant un rôle crucial dans la vie cellulaire. Dans la mitochondrie, il est surtout utilisé comme co-enzyme d'oxydo-réduction afin de produire de l'énergie sous forme d'ATP (respiration ...
MORISOD, L.
core  

Crystal structure of ADP-ribosyl cyclase [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 1996
C. D. Stout, G. Sridhar Prasad, E. A. Stura, D. E. McRee, D. G. Levitt, H. C. Lee   +5 more
openaire   +1 more source

CD38 as theranostic target in oncology

Journal of Translational Medicine
CD38 is a multifunctional transmembrane glycoprotein found in multiple tissues and overexpressed in many cancer cells, notably in hematological malignancies such as leukemia and multiple myeloma (MM).
Valentina Bocuzzi, Jessica Bridoux, Michelle Pirotte, Nadia Withofs, Roland Hustinx, Matthias D’Huyvetter, Jo Caers, Guillaume Marcion   +7 more
doaj   +1 more source