Results 1 to 10 of about 2,560 (93)
Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos. [PDF]
Dev Biol, 2019 We recently demonstrated the requirement of two-pore channel type 2 (TPC2)-mediated Ca2+ release during slow muscle cell differentiation and motor circuit maturation in intact zebrafish embryos. However, the upstream trigger(s) of TPC2/Ca2+ signaling during these developmental processes remains unclear.
Kelu JJ, Webb SE, Galione A, Miller AL.
europepmc +7 more sources
Novel peptide inhibitor of ecto-ADP-ribosyl cyclase of bone marrow stromal cell antigen-1 (BST-1/CD157) [PDF]
Biochemical Journal, 1999 cADP-ribose, which is produced by ecto-ADP-ribosyl cyclase of CD38 or bone marrow stromal cell antigen-1 (BST-1), is a key regulator of Ca2+-induced calcium release in an Ins(1,4,5)P3-independent manner. In the present study, we have identified a specific peptide inhibitor for ADP-ribosyl cyclase of BST-1.
A, Sato +4 more
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ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST‐1 [PDF]
FEBS Letters, 1994 Human BST‐1, a bone marrow stromal cell surface molecule, is a GPI‐anchored protein that facilitates the growth of pre‐B cells. The deduced amino acid sequences of human and mouse BST‐1 show around 30% homology with those of CD38 and Aplysia ADP ribosyl cyclase. Therefore, like CD38, BST‐1 might possess ADP ribosyl cyclase activity. Here, we report the
Hirata, Yuichi +9 more
openaire +3 more sources
Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide+-converting enzymes: extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP-ribosyl cyclase. [PDF]
The Journal of Immunology, 1997 Abstract The human leukocyte Ag CD38 is a 45-kDa type II membrane glycoprotein that functions both as a transmembrane signaling receptor and as an ectoenzyme. CD38 can transmit positive or negative signals regulating T and B lymphocyte proliferation and differentiation and can enzymatically convert nicotinamide adenine dinucleotide to ...
FERRERO, Enza, MALAVASI, Fabio
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American Journal of Physiology-Renal Physiology, 2009 ADP ribosyl (ADPR) cyclases comprise a family of ectoenzymes recently shown to influence cytosolic Ca2+concentration in a variety of cell types. At least two ADPR cyclase family members have been identified in mammals: CD38 and CD157. We recently found reduced renal vascular reactivity to angiotensin II (ANG II), endothelin-1 (ET-1), and norepinephrine
Tiffany L, Thai, William J, Arendshorst
openaire +4 more sources
The FASEB Journal, 2008 Vasoconstriction is mediated by increases in cytosolic calcium concentration ([Ca 2+ ] i ). ADP ribosyl cyclases regulate [Ca2+] i via metabolite activation of Ca 2 ...
Tiffany L Thai, William J Arendshorst
openaire +2 more sources
Conceptual framework for SARS-CoV-2–related lymphopenia
Advanced Biomedical Research, 2022 The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is associated with high morbidity and mortality rates globally. One of the most prominent characteristics of coronavirus disease-19 (COVID-19) is lymphopenia, which is ...
Ilnaz Rahimmanesh +3 more
doaj +1 more source
Frontiers in Medicine, 2022 Chronic kidney disease is a progressive disease that may lead to end-stage renal disease. Interstitial fibrosis develops as the disease progresses. Therapies that focus on fibrosis to delay or reverse progressive renal failure are limited.
Tsuyoshi Inoue +23 more
doaj +1 more source
Ectonucleotidases in Acute and Chronic Inflammation
Frontiers in Pharmacology, 2021 Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani +2 more
doaj +1 more source