Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos. [PDF]
Dev Biol, 2019 We recently demonstrated the requirement of two-pore channel type 2 (TPC2)-mediated Ca2+ release during slow muscle cell differentiation and motor circuit maturation in intact zebrafish embryos. However, the upstream trigger(s) of TPC2/Ca2+ signaling during these developmental processes remains unclear.
Kelu JJ, Webb SE, Galione A, Miller AL.
europepmc +5 more sources
Conceptual framework for SARS-CoV-2–related lymphopenia
Advanced Biomedical Research, 2022 The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is associated with high morbidity and mortality rates globally. One of the most prominent characteristics of coronavirus disease-19 (COVID-19) is lymphopenia, which is ...
Ilnaz Rahimmanesh +3 more
doaj +1 more source
Frontiers in Medicine, 2022 Chronic kidney disease is a progressive disease that may lead to end-stage renal disease. Interstitial fibrosis develops as the disease progresses. Therapies that focus on fibrosis to delay or reverse progressive renal failure are limited.
Tsuyoshi Inoue +23 more
doaj +1 more source
Ectonucleotidases in Acute and Chronic Inflammation
Frontiers in Pharmacology, 2021 Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani +2 more
doaj +1 more source
Multiomic analysis revealed the regulatory role of the KRT14 gene in eggshell quality
Frontiers in Genetics, 2022 Background: Eggshell strength and thickness are critical factors in reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality.
Yan Wu +10 more
doaj +1 more source
Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn2+-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase [PDF]
, 2015 Among metallo-dependent phosphatases, ADP-ribose/CDP-alcohol diphosphatases form a protein family (ADPRibase-Mn-like) mainly restricted, in eukaryotes, to vertebrates and plants, with preferential expression, at least in rodents, in immune cells. Rat and
Cabezas, Alicia +8 more
core +8 more sources
Novel peptide inhibitor of ecto-ADP-ribosyl cyclase of bone marrow stromal cell antigen-1 (BST-1/CD157) [PDF]
Biochemical Journal, 1999 cADP-ribose, which is produced by ecto-ADP-ribosyl cyclase of CD38 or bone marrow stromal cell antigen-1 (BST-1), is a key regulator of Ca2+-induced calcium release in an Ins(1,4,5)P3-independent manner. In the present study, we have identified a specific peptide inhibitor for ADP-ribosyl cyclase of BST-1.
A, Sato +4 more
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Scientific Reports, 2021 CD157/BST-1 (a member of the ADP-ribosyl cyclase family) is expressed at variable levels in 97% of patients with acute myeloid leukemia (AML), and is currently under investigation as a target for antibody-based immunotherapy. We used peripheral blood and
Yuliya Yakymiv +9 more
doaj +1 more source
Phenobarbital induces alterations in the proteome of hepatocytes and mesenchymal cells of rat livers. [PDF]
PLoS ONE, 2013 Preceding studies on the mode of action of non-genotoxic hepatocarcinogens (NGCs) have concentrated on alterations induced in hepatocytes (HCs). A potential role of non-parenchymal liver cells (NPCs) in NGC-driven hepatocarcinogenesis has been largely ...
Philip Klepeisz +5 more
doaj +1 more source
Endogenous ADP-ribosylation of the G Protein β Subunit Prevents the Inhibition of Type 1 Adenylyl Cyclase [PDF]
Journal of Biological Chemistry, 2000 Mono-ADP-ribosylation is a post-translational modification of cellular proteins that has been implicated in the regulation of signal transduction, muscle cell differentiation, protein trafficking, and secretion. In several cell systems we have observed that the major substrate of endogenous mono-ADP-ribosylation is a 36-kDa protein.
Rosita Lupi +2 more
openaire +3 more sources