Results 11 to 20 of about 4,363 (152)

The Na⁺/K⁺-ATPase β1 Subunit is a Kidney ADP-Ribosyl Cyclase. [PDF]

FASEB J
This study highlights that the β1 subunit of Na, K‐ATPase, known as Atp1b1, functions as an ADP‐ribosyl cyclase in rat kidney (kARC). We found that reducing Atp1b1 expression in mouse mesangial cells suppressed angiotensin II (AngII)–induced synthesis of cyclic ADP‐ribose (cADPR) and the associated sustained Ca2+ signaling.
Nam TS, Choe SK, Kim UH.
europepmc   +2 more sources

Synthesis of Bispecific Conjugates by ADP-Ribosyl Cyclases. [PDF]

Adv Sci (Weinh)
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Kim SH, Ansari AJ, Zhang L, Kao G, Hoang TO, Zhang Z, Singireddi S, Katz BB, Zhang Y.   +8 more
europepmc   +2 more sources

CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1. [PDF]

IUBMB Life
Abstract Cyclic ADP‐ribose (cADPR) has emerged as a calcium‐regulating second messenger in smooth muscle cells. CD38 protein possesses ADP‐ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We have previously shown that CD38 expression is regulated by estrogen and progesterone in the myometrium.
Dogan S, Walseth TF, Guvenc Tuna B, Uçar E, Kannan MS, Deshpande DA.   +5 more
europepmc   +2 more sources

Changes in NAD/ADP-ribose metabolism in rectal cancer

Brazilian Journal of Medical and Biological Research, 2005
The extent of ADP-ribosylation in rectal cancer was compared to that of the corresponding normal rectal tissue. Twenty rectal tissue fragments were collected during surgery from patients diagnosed as having rectal cancer on the basis of pathology results.
L. Yalcintepe, L. Turker-Sener, A. Sener, G. Yetkin, D. Tiryaki, E. Bermek   +5 more
doaj   +1 more source

Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca2+ signaling pathway [PDF]

, 2014
published_or_final_versio
Graeff, RM, Wei, W, Yue, J
core   +1 more source

ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST‐1

FEBS Letters, 1994
Human BST‐1, a bone marrow stromal cell surface molecule, is a GPI‐anchored protein that facilitates the growth of pre‐B cells. The deduced amino acid sequences of human and mouse BST‐1 show around 30% homology with those of CD38 and Aplysia ADP ribosyl cyclase. Therefore, like CD38, BST‐1 might possess ADP ribosyl cyclase activity. Here, we report the
Hirata, Yuichi, Kimura, Naoki, Sato, Koh, Ohsugi, Yoshiyuki, Takasawa, Shin, Okamoto, Hiroshi, Ishikawa, Jun, Kaisho, Tsuneyasu, Ishihara, Katsuhiko, Hirano, Toshio   +9 more
openaire   +2 more sources

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Prokaryotic defense systems: Diversity and evolutionary adaptation. [PDF]

mLife
Abstract Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse antiviral mechanisms across distinct stages of viral ...
Yang C, Gong L, Guo J, Xiang H.
europepmc   +2 more sources

Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson’s disease

Frontiers in Behavioral Neuroscience, 2014
CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in
Olga eLopatina, Toru eYoshihara, Tomoko eNishimura, Jing eZhong, Shirin eAkther, Azam AKM Fakhrul, Mingkun eLiang, Chiharu eHigashida, Kohei eSumi, Kazumi eFuruhara, Yuki eInahata, Jianjun eHuang, Keita eKoizumi, Shigeru eYokoyama, Takahiro eTsuji, Yu ePetugina, Andrei eSumarukov, Alla B. Salmina, Koji eHashida, Yasuko eKitao, Osamu eHori, Masahide eAsano, Yoji eKitamura, Takashi eKozaka, Kazuhiro eShiba, Fangfang eZhong, Min-Jue eXie, Makoto eSato, Katsuhiko eIshihara, Haruhiro eHigashida   +29 more
doaj   +1 more source

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs [PDF]

, 2018
Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca2+-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts.
Borbone, Nicola, Catalanotti, Bruno, Costantino, Valeria, D'Errico, Stefano, Mayol, Luciano, Oliviero, Giorgia, Pannaccione, Anna, Petrozziello, Tiziana, Piccialli, Gennaro, Piccialli, Ilaria, Secondo, Agnese   +10 more
core   +2 more sources