Results 21 to 30 of about 4,363 (152)

Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS [PDF]

, 2015
ADP-ribosylation is a posttranslational modification that modulates the functions of many target proteins. We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal-binding protein-1 short-form/BFA-ADP ...
Colanzi, Antonino, Corda, Daniela, Lalioti, Vasiliky S.   +2 more
core   +1 more source

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome [PDF]

, 2014
Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD+ metabolism has emerged as a plausible strategy to ameliorate metabolic ...
Barbosa, Maria Thereza, Capellini, Verena, Chini, Eduardo N., Escande, Carlos, Gomes, Ana P., Nin, Veronica, O’Neil, Luke, Price, Nathan L., Sinclair, David A., White, Thomas A.   +9 more
core   +1 more source

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms

Mediators of Inflammation, 2018
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande, Alonso G. P. Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian, Timothy F. Walseth, Mathur S. Kannan   +6 more
doaj   +1 more source

HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms

Journal of Neuroinflammation, 2011
Background Infection with human immunodeficiency virus type-1 (HIV)-1 leads to some form of HIV-1-associated neurocognitive disorders (HAND) in approximately half of the cases.
Mamik Manmeet K, Banerjee Sugato, Walseth Timothy F, Hirte Renee, Tang Lin, Borgmann Kathleen, Ghorpade Anuja   +6 more
doaj   +1 more source

Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin II, endothelin-1, and norepinephrine

American Journal of Physiology-Renal Physiology, 2009
ADP ribosyl (ADPR) cyclases comprise a family of ectoenzymes recently shown to influence cytosolic Ca2+concentration in a variety of cell types. At least two ADPR cyclase family members have been identified in mammals: CD38 and CD157. We recently found reduced renal vascular reactivity to angiotensin II (ANG II), endothelin-1 (ET-1), and norepinephrine
Tiffany L, Thai, William J, Arendshorst
openaire   +3 more sources

Effects of magnesium with or without boron on headshaking behavior in horses with trigeminal-mediated headshaking. [PDF]

, 2019
BackgroundOral administration of magnesium and boron might have a beneficial effect on headshaking behavior in horses.ObjectiveEvaluate the effects of oral magnesium alone or in combination with boron on headshaking behavior in affected horses ...
Aleman, Monica, Costa, Lais RR, Howey, Quinn, Madigan, John E, Sheldon, Shara A, Weich, Kalie   +5 more
core   +2 more sources

Immuno-targeting the multifunctional CD38 using nanobody [PDF]

, 2016
published_or_final_versio
Deng, QW, Hao, Q, Hou, YN, Koch-Nolte, F, Lam, MC, Lee, HC, Li, T, Liu, J, Qi, S, Unger, M, Wang, XW, Xin, D, Zhang, H, Zhang, P, Zhao, YJ   +14 more
core   +1 more source

From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors

Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism‐based 1,2,3‐triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP‐ribose (ADPR) adducts from NAD+. These trapped intermediates stall the enzyme in an inactive state, providing a biocompatible alternative to thiocarbonyl inhibitors and a blueprint ...
Florian Friedrich, Marat Meleshin, Niklas Papenkordt, Lena Gaitzsch, Isabel Prucker, Marco Borso, Jan Ruprecht, Christopher Vorreiter, Sabrina Rast, Lin Zhang, Matthias Schiedel, Wolfgang Sippl, Axel Imhof, Henning J. Jessen, Oliver Einsle, Mike Schutkowski, Manfred Jung   +16 more
wiley   +2 more sources

The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]

, 2015
The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika, Nikiforov, Andrey, Ziegler, Mathias   +2 more
core   +2 more sources

Immune Cell Proteins and Parkinson's Disease: A Mendelian Randomization Analysis of Causal Associations. [PDF]

Brain Behav
Mendelian randomization (MR) analysis was applied to elucidate the causal relationship between immune cell proteins and PD. Our study reveals a possible causal effect of immune cell proteins on the risk of PD and provides new ideas for the prevention and management of PD through immune cell proteins.
Li H, He J, Xuan T, Gu S, Niu X, Ren Y, Zhan X, Cheng J.   +7 more
europepmc   +2 more sources