Results 41 to 50 of about 4,363 (152)

Модуляция активности АДФ-рибозилциклазы при ишемии головного мозга [PDF]

, 2012
Второе место среди причин смертности и инвалидизации больных занимают острые нарушения мозгового кровообращения. Цель исследования - оценить влияние модуляторов активности АДФ-рибозилциклазы/CD38 в нейронах и клетках нейроглиальной природы в ...
Баглаева, Ольга Владимировна, Гасымлы, Эльтадж Джамил кызы, Кувачева, Наталья Валерьевна, Малиновская, Наталия Александровна, Морозова, Галина Александровна, Панина, Юлия Анатольевна, Петрова, Марина Михайловна, Салмина, Алла Борисовна, Фролова, Ольга Васильевна   +8 more
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Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate [PDF]

, 2015
Transient receptor potential melastatin 2 (TRPM2), a Ca(2+)-permeable cation channel implicated in postischemic neuronal cell death, leukocyte activation, and insulin secretion, is activated by intracellular ADP ribose (ADPR).
Aarhus, Balázs Tóth, Beck, Brailoiu, Calcraft, Churamani, Csanády, Fliegert, Fonfria, Hara, Hermosura, Iordan Iordanov, Kaneko, Koch-Nolte, Kolisek, Lange, Lin, László Csanády, Malavasi, McHugh, Moreau, Nagamine, Olah, Perraud, Perraud, Perraud, Perraud, Sano, Schmid, Togashi, Tóth, Tóth, Tóth, Uchida, Wang, Wehage, Yamamoto   +36 more
core   +2 more sources

Oxytocin Enhances Demethylation Through TET Enzyme Expression in Neurons of Aged Mice: Oxytocin as a Potential Antiaging Peptide

Aging Cell, Volume 24, Issue 10, October 2025.
DNA methylation, mitochondrial dysfunction, inflammation, and senescence interact to form a vicious cycle. Here we report that oxytocin interrupts this vicious cycle by increasing TET2 expression, inducing DNA demethylation in aged neurons and raising plasma oxytocin levels, decreasing systemic inflammation.
Yuko Maejima, Shoko Yokota, Megumi Yamachi, Shizu Hidema, Tomoyuki Ono, Shu Taira, Katsuhiko Nishimori, Heidi de Wet, Kenju Shimomura   +8 more
wiley   +1 more source

Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma? [PDF]

, 2000
The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is produced in considerable quantities in asthmatic airways, may potentially ...
RA Panettieri Jr, SR Johnson, Y Amrani, PN Bouchelouche, BE Corkey, H Koller, F Peiretti, MA Schumann, R Beyaert, BE Rapuano, MF Wilkinson, B Cheng, G Garcia, KA Krown, LM Renzetti, Y Amrani, Y Amrani, Y Amrani, K Hotta, Y Nakatani, JRM Parris, LA Tartaglia, Y Amrani, H Hsu, H Hsu, Y Amrani, N Auphan, O Thastrup, Y Amrani, BA Reilly, H Aktas, HL Pahl, OA Adebanjo   +32 more
core   +1 more source

Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

MedComm, Volume 6, Issue 9, September 2025.
This article reviews the roles of 5‐HT metabolism, 5‐HT receptors, and their related signaling pathways in normal physiology and various diseases, and explores their potential value in disease treatment, providing a reference basis for research and clinical treatment in related fields. ABSTRACT Serotonin (5‐hydroxytryptamine; 5‐HT) is an evolutionarily
Yuxin Zhang, Nan Wang, Louqian Zhang, Yan Zhuang, Qilei Xin, Xiaosong Gu, Chunping Jiang, Junhua Wu   +7 more
wiley   +1 more source

A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. [PDF]

, 2020
Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization.
Bier, Ethan, Franc, Nathalie C, Guichard, Annabel, Roy, Sitara, Schwartz, Ruth   +4 more
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Nitrosative stress and pharmacological modulation of heart failure [PDF]

, 2005
Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the reaction of nitric oxide with superoxide anion and ...
Liaudet, L., Pacher, P., Schulz, R., Szabo, C.   +3 more
core   +1 more source

Metabolic fate of extracellular NAD in human skin fibroblasts [PDF]

, 2001
Extracellular NAD is degraded to pyridine and purine metabolites by different types of surface-located enzymes which are expressed differently on the plasmamembrane of various human cells and tissues.
A. PRETI, ALEO M.F, DANESI P, GIUDICI M.L, POMPUCCI G, SESTINI S   +5 more
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Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

MedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao   +12 more
wiley   +1 more source

Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma

Immunological Reviews, Volume 330, Issue 1, March 2025.
ABSTRACT Asthma has become more appreciated for its heterogeneity with studies identifying type 2 and non‐type 2 phenotypes/endotypes that ultimately lead to airflow obstruction, airway hyperresponsiveness, and remodeling. The pro‐inflammatory environment in asthma influences airway smooth muscle (ASM) structure and function.
Maria L. Ford, Mohammad Irshad Reza, Anushka Ruwanpathirana, Venkatachalem Sathish, Rodney D. Britt Jr   +4 more
wiley   +1 more source