Results 51 to 60 of about 4,363 (152)

The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques

ChemBioChem, Volume 26, Issue 3, February 1, 2025.
This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley   +1 more source

Exploring NAD(+) metabolism in host-pathogen interactions [PDF]

, 2016
Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate.
Belinha, Ana, Gaifem, Joana, Mesquita, Inês Morais, Silvestre, Ricardo Jorge Leal   +3 more
core   +1 more source

Tartary Buckwheat Bran and Fructus Aurantii Combination (TBB‐FA): A Promising Therapeutic Approach for Functional Dyspepsia via Modulation of Gut Microbiota, Short‐Chain Fatty Acids and Purine Signaling Pathway

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
Fructus aurantii, stir‐baked with Tartary buckwheat bran, was employed as a treatment for functional dyspepsia (FD). The potential of this combination to replace or supplement wheat bran was thoroughly assessed. The purinergic signaling system holds potential as a therapeutic target for gastrointestinal disorders, thereby facilitating the development ...
Di Wang, Xiaobo Zeng, Xinge Wang, Wen Wen, Ping Wang, Shijun Xu   +5 more
wiley   +1 more source

Molecular aspects of Bordetella pertussis pathogenesis [PDF]

, 2010
The molecular mechanisms of Bordetella virulence are now well understood, and many virulence factors have been identified and characterized at the molecular level.
Camille Locht
core   +2 more sources

Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]

, 2016
Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E., Farquharson, Andrew J., Horgan, Graham W, Williams, Lynda M.   +3 more
core   +1 more source

Age‐related increase of CD38 directs osteoclastogenic potential of monocytic myeloid‐derived suppressor cells through mitochondrial dysfunction in male mice

Aging Cell, Volume 23, Issue 11, November 2024.
Aged M‐MDSCs have increased osteoclastogenesis potential. Transcriptomic analyses revealed the upregulation of mitochondrial oxidative phosphorylation and glucose metabolism genes, especially CD38 or NADase. A specific CD38 inhibitor reduced the mitochondrial oxygen consumption rate and glucose metabolism and inhibited the osteoclastogenic potential of
Ramkumar Thiyagarajan, Lixia Zhang, Omar D. Glover, Kyu Hwan Kwack, Sara Ahmed, Emma Murray, Nanda Kumar Yellapu, Jonathan Bard, Kenneth L. Seldeen, Spencer R. Rosario, Bruce R. Troen, Keith L. Kirkwood   +11 more
wiley   +1 more source

Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity

Pediatric Obesity, Volume 19, Issue 9, September 2024.
Summary Objective Children with overweight/obesity (OW/OB) exhibit poor cardiometabolic health, yet mechanisms influencing brain health remain unclear. We examined the differences in neurological‐related circulating proteins in plasma among children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and the association ...
Marcos Olvera‐Rojas, Abel Plaza‐Florido, Patricio Solis‐Urra, Francisco J. Osuna‐Prieto, Francisco B. Ortega   +4 more
wiley   +1 more source

Impaired instructive and protective barrier functions of the endothelial cell glycocalyx pericellular matrix is impacted in COVID‐19 disease

Journal of Cellular and Molecular Medicine, Volume 28, Issue 16, August 2024.
Abstract The aim of this study was to review the roles of endothelial cells in normal tissue function and to show how COVID‐19 disease impacts on endothelial cell properties that lead to much of its associated symptomatology. This places the endothelial cell as a prominent cell type to target therapeutically in the treatment of this disorder.
Margaret M. Smith, James Melrose
wiley   +1 more source

The two-pore channel TPCN2 mediates NAADP-dependent Ca-release from lysosomal stores [PDF]

, 2009
Second messenger-induced Ca2+-release from intracellular stores plays a key role in a multitude of physiological processes. In addition to 1,4,5-inositol trisphosphate (IP3), Ca2+, and cyclic ADP ribose (cADPR) that trigger Ca2+-release from the ...
Xiangang Zong, Michael Schieder, Hartmut Cuny, Stefanie Fenske, Christian Gruner, Katrin Rötzer, Oliver Griesbeck, Hartmann Harz, Martin Biel, Christian Wahl-Schott, A Beck, G Berridge, MJ Berridge, FX Boittin, EJ Bowman, LM Broad, PJ Calcraft, JM Cancela, D Churamani, GC Churchill, DE Clapham, DE Clapham, A Galione, A Galione, JV Gerasimenko, G Grynkiewicz, AH Guse, K Ishibashi, HC Lee, HC Lee, F Malavasi, R Masgrau, K Mikoshiba, AJ Morgan, B Much, E Peiter, BC Schroeder, M Steen, H Streb, C Wahl-Schott, FH Yu, R Zalk, N Zerangue   +42 more
core   +1 more source

Evolution of fungal tuberculosis necrotizing toxin (TNT) domain‐containing enzymes reveals divergent adaptations to enhance NAD cleavage

Protein Science, Volume 33, Issue 7, July 2024.
Abstract Tuberculosis necrotizing toxin (TNT) is a protein domain discovered on the outer membrane of Mycobacterium tuberculosis (Mtb), and the fungal pathogen Aspergillus fumigatus. TNT domains have pure NAD(P) hydrolytic activity, setting them apart from other NAD‐cleaving domains such as ADP‐ribosyl cyclase and Toll/interleukin‐1 receptor homology ...
Eugenio Ferrario, Juha Pekka Kallio, Mahdi Emdadi, Øyvind Strømland, Johannes G. M. Rack, Mathias Ziegler   +5 more
wiley   +1 more source