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Advanced Glycation End Products and Bone Loss during Aging
Annals of the New York Academy of Sciences, 2005Abstract: It is well known that bone mass density decreases with age. Age‐related bone mass loss is ascribed to several factors. Nonenzymatic glycation has been proposed as a new potential factor in the loss of bone during aging. In this study we evaluated the concentration of pentosidine, an advanced glycation end product, in cortical and trabecular ...
ODETTI, PATRIZIO +6 more
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Advanced Glycation End Products (AGEs) and Diabetic Vascular Complications
Current Diabetes Reviews, 2005Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes. Chronic hyperglycemia is essentially involved in the development and progression of diabetic micro- and ...
Sho-ichi, Yamagishi +2 more
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Bone Aging by Advanced Glycation End Products
Journal of Dental Research, 2015The quality and quantity of mandibular bone are essential prerequisites for osseointegrated implants. Only the Hounsfield unit on preoperative computed tomography is currently used as a clinical index. Nevertheless, a considerable mismatch occurs between bone quality and the Hounsfield unit.
K, Ganeko +7 more
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AGEs (Advanced Glycation End-products) in bone come of age
BoneAdvanced Glycation End-products (AGEs) are seen in long-lived proteins and were not expected to accumulate in the bone that turnovers and renews itself. Here, we provide a commentary on the contrary, highlighting the Special Issue of AGEs in Bone. An outcome of hyperglycemia and increased oxidative stress, AGEs form and accumulate by altering the bone ...
Deepak, Vashishth +2 more
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Advanced Glycation End Products, RAGE, and Aging
2010The products of nonenzymatic glycation and oxidation of proteins and lipids, the advanced glycation end products (AGEs), accumulate in diverse biological settings including aging. AGEs may be generated rather quickly or over long duration as a consequence of distinct triggering mechanisms, thereby accounting for their roles in multiple settings and ...
Ravichandran Ramasamy +3 more
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Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation
2020A range of chemically different compounds are known to inhibit the formation and accumulation of advanced glycation end products (AGEs) or disrupt associated signalling pathways. There is evidence that some of these agents can provide end-organ protection in chronic diseases including diabetes.
Karly C, Sourris +2 more
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Smooth Muscle Cell Pathophysiology and Advanced Glycation End Products (AGEs)
Current Drug Targets, 2010Accelerated atherosclerosis is the leading cause of coronary heart disease and stroke, which could account for high mortality rates in patients with diabetes. Although several hyperglycemia-elicited metabolic and hemodynamic derangements have been implicated in the pathogenesis of cardiovascular disease (CVD) in diabetes, the process of formation and ...
Sho-ichi, Yamagishi, Takanori, Matsui
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Involvement of Advanced Glycation End-products (AGEs) in Alzheimers Disease
Current Alzheimer Research, 2004The advanced stage of the glycation process (one of the post-translational modifications of proteins) leads to the formation of advanced glycation end-products (AGEs) and plays an important role in the pathogenesis of angiopathy in diabetic patients.
Masayoshi, Takeuchi +7 more
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Advanced Glycation End Products (AGEs), Oxidative Stress and Diabetic Retinopathy
Current Pharmaceutical Biotechnology, 2011Diabetic retinopathy is a common and devastating microvascular complication in diabetes and is a leading cause of acquired blindness among the people of occupational age. Recent large landmark clinical studies have shown that intensive control of blood glucose or blood pressure (BP) reduces the risk for diabetic retinopathy. However, the strict control
Sho-ichi, Yamagishi, Takanori, Matsui
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[Importance of advanced glycation end products--AGE products].
Bratislavske lekarske listy, 1998Recent experimental findings suggest that free oxygen radicals and AGEs may be significantly involved in the onset and development of chronic diabetic complications and Alzheimer's disease. The presented review summarizes knowledge on structure and rise of these products in vitro and in vivo and the chemical and biological properties of advanced ...
V, Jakus, J, Cársky, M, Hrnciarová
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