Results 241 to 250 of about 63,117 (342)

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, Volume 182, Issue 21, Page 5355-5377, November 2025.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source

The Role of Micronutrients in Atherosclerosis: Mechanisms and Clinical Application

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Micronutrients, though required in relatively small quantities by the human body, are essential for maintaining normal physiological functions and play a crucial role in the prevention and management of various diseases. Atherosclerosis (AS) is a common chronic inflammatory condition that often presents without obvious symptoms in its early ...
Yuxin Ouyang, Weiwei Jiang, Xiongquan Long, Peng Mao, Pingping He, Xinping Ouyang   +5 more
wiley   +1 more source

Exploring the Causal Relationship Between Blood Metabolites and Chronic Periodontitis: Insights From Genetic Causal Analysis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT To investigate the potential bidirectional causal relationship between specific blood metabolites and chronic periodontitis using Mendelian randomisation (MR). A two‐sample bidirectional MR analysis was conducted. Data on 1400 blood metabolites were obtained from a genome‐wide association study involving 8299 participants.
Weilun Cai, Huaxuan Zhao, Panpan Wang, Xiao Chen, Yumeng Yang, Hongle Wu, Zehao Chen, Fuchun Fang, Wei Qiu   +8 more
wiley   +1 more source

Natural Antioxidants and Hydrocolloids as a Mitigation Strategy to Inhibit Advanced Glycation End Products (AGEs) and 5-Hydroxymethylfurfural (HMF) in Butter Cookies. [PDF]

Foods, 2022
Hu H, Wang Y, Huang Y, Yu Y, Shen M, Li C, Nie S, Xie M.   +7 more
europepmc   +1 more source

An advanced glycation end product (AGE)-receptor for AGEs (RAGE) axis restores adipogenic potential of senescent preadipocytes through modulation of p53 protein function.

, 2013
Chih‐Yu Chen, Allison Martorano Abell, Yang Soo Moon, Kee‐Hong Kim   +3 more
openalex   +1 more source

Clinical factors associated with advanced glycation end-products (AGEs) levels evaluated by skin autofluorescence of schoolchildren in Japan. [PDF]

Clin Pediatr Endocrinol
Nagahara K, Motegi S, Ochi A, Toyoda J, Nakano Y, Imai T, Adachi M, Yamagishi SI, Mizuno K.   +8 more
europepmc   +1 more source

Advanced glycation end-products (AGEs) are lower in prostate tumor tissue and inversely related to proportion of West African ancestry. [PDF]

Prostate, 2022
Zenner ML, Helou YB, Deaton RJ, Sverdlov M, Wang H, Kajdacsy-Balla A, Macias V, Voisine C, Murray M, Abdulkadir SA, Murphy AB, Nonn L.   +11 more
europepmc   +1 more source

Histidine‐Containing Dipeptides in Obesity and Cardiometabolic Health: A Systematic Scoping Review

Obesity Reviews, Volume 26, Issue 11, November 2025.
ABSTRACT Background Histidine‐containing dipeptides (HCDs) have been reported to have anti‐inflammatory and antidiabetic properties. Yet, no previous reviews have examined the impact of HCDs on Type 2 diabetes (T2D) risk factors (e.g., obesity) and progression (e.g., microvascular and macrovascular complications).
Saeede Saadati, Robel Hussen Kabthymer, Giancarlo Aldini, Thilini R. Thrimawithana, Julie E. Stevens, Kathy Ngyuen, Arshad Majid, Simon M. Bell, Jack Feehan, Aya Mousa, Barbora de Courten   +10 more
wiley   +1 more source

Relationships between advanced glycation end products (AGEs), vasoactive substances, and vascular function. [PDF]

J Smooth Muscle Res, 2021
Matsumoto T, Taguchi K, Kobayashi T.
europepmc   +1 more source

Decoding Glycosylation in Neurodegenerative Diseases: Mechanistic Insights and Therapeutic Opportunities

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Graphical summary of glycosylation impairments in various neurodegenerative disorders. Among the diverse forms of glycosylation, the most extensively studied include N‐glycosylation, O‐glycosylation, and O‐GlcNAcylation. Aberrant glycosylation has been implicated in multiple neurodegenerative conditions.
Haihan Yu, Xing Chen, Yang Yang, Mengke Gu, Kaidi Ren, Ziqing Wei   +5 more
wiley   +1 more source