SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis
Frontiers in Cell and Developmental Biology, 2022 Increased dependence on aerobic glycolysis is characteristic of most cancer cells, whereas the mechanism underlying the promotion of aerobic glycolysis in metastatic breast cancer cells under ambient oxygen has not been well understood.
Chenguang Yao +7 more
doaj +2 more sources
Aerobic Glycolysis: A DeOxymoron of (Neuro)Biology
Metabolites, 2022 The term ‘aerobic glycolysis’ has been in use ever since Warburg conducted his research on cancer cells’ proliferation and discovered that cells use glycolysis to produce adenosine triphosphate (ATP) rather than the more efficient oxidative ...
Avital Schurr, Salvatore Passarella
doaj +2 more sources
Journal of Experimental & Clinical Cancer Research, 2022 Background RNA-binding proteins (RBPs) and circular RNAs (circRNAs) play important roles in glioblastoma multiforme (GBM). Aerobic glycolysis is a metabolic characteristic of GBM.
Jian Song +11 more
doaj +2 more sources
The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma [PDF]
PeerJThis review delves into the pivotal role and intricate mechanisms of aerobic glycolysis in nasopharyngeal carcinoma (NPC). NPC, a malignancy originating from the nasopharyngeal epithelium, displays distinct geographical and clinical features. The article
Zhiyong Pan +10 more
doaj +3 more sources
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Annual Review of Cell and Developmental Biology, 2011 Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells.
Sophia Y Lunt, Matthew G Vander Heiden
exaly +2 more sources
Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma
Journal of Experimental & Clinical Cancer Research, 2020 Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sorafenib is the first targeted drug for advanced
Jiao Feng +7 more
doaj +2 more sources
M6A-modified BFSP1 induces aerobic glycolysis to promote liver cancer growth and metastasis through upregulating tropomodulin 4 [PDF]
Molecular BiomedicineRNA N6-methyladenosine (m6A) is a common RNA modification in eukaryotes, and its abnormal regulation is closely related to cancer progression. Aerobic glycolysis is a main way for cancer cells to obtain energy.
Rong Li +9 more
doaj +2 more sources
IGF2BP1 accelerates the aerobic glycolysis to boost its immune escape in hepatocellular carcinoma microenvironment [PDF]
Frontiers in ImmunologyIntroductionEnergy metabolism abnormity emerges as a crucial factor that facilitates tumorigenesis by accelerating aerobic glycolysis. However, the function of N6-methyladenosine (m6A) on hepatocellular carcinoma (HCC) aerobic glycolysis and immune ...
Xuxing Ye +3 more
doaj +2 more sources
N6‐isopentenyladenosine inhibits aerobic glycolysis in glioblastoma cells by targeting PKM2 expression and activity [PDF]
FEBS Open BioGlioblastoma (GBM) is a primary tumor in the central nervous system with poor prognosis. It exhibits elevated glucose uptake and lactate production. This metabolic state of aerobic glycolysis is known as the Warburg effect. N6‐isopentenyladenosine (iPA),
Cristina Pagano +10 more
doaj +2 more sources
Focal adhesion kinase promotes aerobic glycolysis in hepatic stellate cells via the cyclin D1/c-Myc/MCT-1 pathway to induce liver fibrosis [PDF]
Scientific ReportsHepatic stellate cells (HSCs) transdifferentiate into myofibroblasts during liver fibrosis and exhibit increased glycolysis. Phosphorylated focal adhesion kinase (FAK) (pY397-FAK) promotes monocarboxylate transporter 1 (MCT-1) expression in HSCs to ...
Tao Huang +6 more
doaj +2 more sources