Results 51 to 60 of about 339,203 (181)

Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer

Science Signaling, 2021
Kidney tumors lacking fumarate hydratase become aggressive due to a metabolic shift arising from altered mitochondrial DNA. A metabolic shift from altered mitochondrial DNA Deficiency in the metabolic enzyme fumarate hydratase distinguishes an aggressive
D. Crooks, N. Maio, M. Lang, C. Ricketts, C. Vocke, Sandeep Gurram, S. Turan, Y. Kim, G. M. Cawthon, Ferri Sohelian, Natalia de Val, R. Pfeiffer, Parthav Jailwala, M. Tandon, Bao Tran, T. Fan, A. Lane, T. Ried, Darawalee Wangsa, A. Malayeri, Maria J Merino, Youfeng Yang, J. Meier, M. Ball, T. Rouault, R. Srinivasan, W. Linehan   +26 more
semanticscholar   +1 more source

Metformin alleviates nickel-refining fumes-induced aerobic glycolysis via AMPK/GOLPH3 pathway in vitro and in vivo

Ecotoxicology and Environmental Safety, 2022
Nickel (Ni) compounds is recognized industrial carcinogen, which could increase the risk of lung cancer in Ni refineries workers. However, the underlying carcinogenic mechanism still remains to elucidate.
Tong Zhang, Yue Wang, Yangyang Chen, Ying Gao, Dan Zhang, Shuo Jin, Wenxue Yao, Lina Li, Shikuan Yang, Yonghui Wu   +9 more
doaj  

Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS

Cell Communication and Signaling, 2019
Oncogenic KRAS plays a vital role in controlling tumor metabolism by enhancing aerobic glycolysis. Obesity driven by chronic consumption of high-fat diet (HFD) is a major risk factor for oncogenic KRAS-mediated pancreatic ductal adenocarcinoma (PDAC ...
Dan Wang, Yawei Bi, Lianghao Hu, Yongde Luo, Juntao Ji, Albert Z. Mao, Craig D. Logsdon, Ellen Li, James L. Abbruzzese, Zhaoshen Li, Vincent W. Yang, Weiqin Lu   +11 more
doaj   +1 more source

H19 promotes aerobic glycolysis, proliferation, and immune escape of gastric cancer cells through the microRNA‐519d‐3p/lactate dehydrogenase A axis

Cancer Science, 2021
Long noncoding RNAs (lncRNAs) have been investigated in multiple human cancers including gastric cancer (GC). Our research aims to explore the role of H19 in aerobic glycolysis, proliferation, and immune escape of GC cells.
Linqing Sun, Juntao Li, Wenying Yan, Zhendong Yao, Ruoqin Wang, Xiaojun Zhou, Hongya Wu, Guangbo Zhang, Tongguo Shi, Weichang Chen   +9 more
semanticscholar   +1 more source

Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Nature Communications, 2020
Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear.
M. Weng, Wan-kun Chen, Xiangyuan Chen, Hong Lu, Zhirong Sun, Q. Yu, Peng-fei Sun, Ya-jun Xu, Minmin Zhu, Nan Jiang, Jin Zhang, Jian-ping Zhang, Yuanda Song, Duan Ma, Xiaoping Zhang, C. Miao   +15 more
semanticscholar   +1 more source

Role of aerobic glycolysis in genetically engineered mouse models of cancer

BMC Biology, 2013
The propensity of cancer cells to convert high levels of glucose to lactate through aerobic glycolysis has been intensively studied in vitro, and is now understood to be a metabolic adaptation that shunts glucose carbons toward building blocks for the ...
Dang Chi V
doaj   +1 more source

The roles of glycolysis in osteosarcoma

Frontiers in Pharmacology, 2022
Metabolic reprogramming is of great significance in the progression of various cancers and is critical for cancer progression, diagnosis, and treatment.
Zuxi Feng, Yanghuan Ou, Liang Hao
doaj   +1 more source

Research Progress of Warburg Effect in Hepatocellular Carcinoma

Frontiers in Bioscience-Landmark
The Warburg effect, also called aerobic glycolysis, refers to tumor cells that metabolize glucose through glycolysis even in the presence of oxygen. This rapid breakdown of glucose fuels the fast development, growth, and migration of tumor cells. Lactate,
Yanguang Yang, Yuting Gao, Yajun Xiong, Yi Gong, Junlan Lu, Yuman Zhang, Dan Wang, Zhihan Liu, Xinli Shi   +8 more
doaj   +1 more source

Decreased Expression of MPC2 Contributes to Aerobic Glycolysis and Colorectal Cancer Proliferation by Activating mTOR Pathway

Journal of Immunology Research, 2021
Mitochondrial Pyruvate Carrier 1 (MPC1), one of the rate-limiting proteins involved in glycolysis metabolism, has been demonstrated as a tumor inhibitor in several cancers.
Manzila Kuerbanjiang, Lei Gu, Chunjie Xu, Wen Ting Xu, Siyuan Wen, Hanbing Xue, Qing Xu   +6 more
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m6A transferase KIAA1429‐stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2021
Emerging evidence has demonstrated that N6‐methyladenosine (m6A) and long noncoding RNAs (lncRNAs) are both crucial regulators in gastric cancer (GC) tumorigenesis. However, the interaction of m6A and lncRNAs in GC progression are still unclear.
De-sheng Yang, S. Chang, Fuchun Li, Mingxiao Ma, Jiayao Yang, Xun Lv, Luxin Huangfu, Changhe Jia   +7 more
semanticscholar   +1 more source