Results 51 to 60 of about 733,038 (191)
Scientific Reports, 2021 Small antibody mimetics that contain high-affinity target-binding peptides can be lower cost alternatives to monoclonal antibodies (mAbs). We have recently developed a method to create small antibody mimetics called FLuctuation-regulated Affinity ...
Kyra See +11 more
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mRNA Display Design of Fibronectin-based Intrabodies That Detect and Inhibit Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein [PDF]
, 2009 The nucleocapsid (N) protein of severe acute respiratory syndrome (SARS) coronavirus plays important roles in both viral replication and modulation of host cell processes.
Amstutz +40 more
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One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX
BMC Biotechnology, 2007 Background As a new class of therapeutic and diagnostic reagents, more than fifteen years ago RNA and DNA aptamers were identified as binding molecules to numerous small compounds, proteins and rarely even to complete pathogen particles.
Stöcklein Walter +11 more
doaj +1 more source
Probing the limits of aptamer affinity with a microfluidic SELEX platform. [PDF]
PLoS ONE, 2011 Nucleic acid-based aptamers offer many potential advantages relative to antibodies and other protein-based affinity reagents, including facile chemical synthesis, reversible folding, improved thermal stability and lower cost.
Kareem M Ahmad +5 more
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The cloning, characterisation and engineering of an IGF-I-BINDING single chain Fv [PDF]
, 2004 This thesis describes the construction and characterisation of an insulin-like growth factor (IGF-I)-binding single chain Fv (scFv) and the utilisation of this scFv as a model protein for the study of the application of DNA shuffling and ribosome display
Roberts, Anthony Simon
core +1 more source
Conformational Dynamics of the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein
Biomedicines, 2022 Variants of SARS-CoV-2 keep emerging and causing new waves of COVID-19 around the world. Effective new approaches in drug development are based on the binding of agents, such as neutralizing monoclonal antibodies to a receptor-binding domain (RBD) of ...
Aleksandra A. Mamchur +8 more
doaj +1 more source
On Affine Selections of Set–Valued Functions [PDF]
JAA, 1995 Abstract The main result of this paper is the theorem stating that every convex set–valued function F : I ↦ c(Y), where I ⊂ R is an interval and Y is a locally convex space, possesses an affine selection. In the case if Y = R and values of F are closed real intervals we can replace the assumption of convexity of F by the more general ...
openaire +3 more sources
Development of Recombinant Antibody by Yeast Surface Display Technology
Current Research in Pharmacology and Drug DiscoveryRecombinant antibodies have emerged as powerful tools in various fields, including therapeutics, diagnostics, and research applications. The selection of high-affinity antibodies with desired specificity is a crucial step in the development of ...
Mujahed I. Mustafa +2 more
doaj +1 more source
Parameters and determinants of responses to selection in antibody libraries.
PLoS Computational Biology, 2021 The sequences of antibodies from a given repertoire are highly diverse at few sites located on the surface of a genome-encoded larger scaffold. The scaffold is often considered to play a lesser role than highly diverse, non-genome-encoded sites in ...
Steven Schulz +6 more
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Analysis of B cell selection mechanisms in the adaptive immune response [PDF]
, 2005 The essential task of a germinal centre reaction is the selection of those B cells that bind the antigen with high affinity. The exact mechanisms of B cell selection is still unknown and rather difficult to be accessed in experiment.
Iber, D. +2 more
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