Results 71 to 80 of about 9,776,047 (207)

Obesity accelerates cardiovascular ageing

European Heart Journal
Abstract A global obesity pandemic, coupled with an increasingly ageing population, is exacerbating the burden of cardiovascular disease. Indeed, clinical and experimental evidence underscores a potential connection between obesity and ageing in the pathogenesis of various cardiovascular disorders. This is further supported by the notion
Ruperez, Celia, Madeo, Frank, de Cabo, Rafael, Kroemer, Guido, Abdellatif, Mahmoud   +4 more
openaire   +3 more sources

Alcohol consumption and epigenetic age acceleration in young adults

Aging, 2023
Alcohol is a widely consumed substance in the United States, however its effect on aging remains understudied. In this study of young adults, we examined whether cumulative alcohol consumption, i.e., alcohol years of beer, liquor, wine, and total alcohol,
D. Nannini, B. Joyce, Yinan Zheng, Tao Gao, Jun Wang, Lei Liu, D. Jacobs, P. Schreiner, Chunyu Liu, Q. Dai, S. Horvath, A. Lu, K. Yaffe, P. Greenland, D. Lloyd-Jones, Lifang Hou   +15 more
semanticscholar   +1 more source

Associations of DNA Methylation Algorithms of Aging With Cardiovascular Disease and Mortality Risk Among US Older Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Several DNA methylation (DNAm) algorithms have recently emerged as robust predictors of aging and adverse health outcomes in older adults, offering valuable insights into cardiovascular disease (CVD) risk stratification.
Xian Cui, Shiqun Sun, Hui Zhang, Yulu Gong, Darong Hao, Yaqian Xu, Chongyu Ding, Jing Wang, Tongyan An, Jinlong Liu, Jun Du, Xiangwei Li   +11 more
doaj   +1 more source

Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics

Clinical Epigenetics, 2018
Background Gestational age at delivery is associated with health and social outcomes. Recently, cord blood DNA methylation data has been used to predict gestational age.
Jasmine N. Khouja, Andrew J. Simpkin, Linda M. O’Keeffe, Kaitlin H. Wade, Lotte C. Houtepen, Caroline L. Relton, Matthew Suderman, Laura D. Howe   +7 more
doaj   +1 more source

Cytomegalovirus infection accelerates epigenetic aging

Experimental Gerontology, 2015
Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e.
Jylhava Juulia, Kananen Laura, Jylha Marja, Marttila Saara, Nevalainen Tapio, Hervonen Antti, Hurme Mikko, Hurme Mikko   +7 more
openaire   +2 more sources

Progeria and Accelerated Cardiovascular Aging

Cardiology Plus, 2018
Hutchinson–Gilford Progeria syndrome (HGPS) is characterized by accelerated aging leading to death in the teen years, usually due to severe coronary and/or carotid disease. The clinical presentation includes stunted growth, alopecia, loss of subcutaneous fat, osteoporosis, and cardiovascular disorders occurring in late childhood and the teen years ...
Brandon K Walther, Yanhui Li, Rajarajan Amirthalingam Thandavarayan, John P Cooke   +3 more
openaire   +2 more sources

Epigenetic Age Acceleration and Disparities in Posttraumatic Stress in Women in Southeast Louisiana

JAMA Network Open
Key Points Question What is the association of epigenetic age acceleration with future development of posttraumatic stress disorder? Findings In this cohort study of 864 women in southeast Louisiana, a significantly higher epigenetic age acceleration and
Alicia K. Smith, S. Katrinli, Dawayland O. Cobb, Evan G Goff, Michael Simmond, Grace M. Christensen, Tyler Prusisz, Sierra N. Garth, Meghan Brashear, Anke Hüls, Erika J. Wolf, Edward Trapido, A. Rung, Nicole R. Nugent, Edward S. Peters   +14 more
semanticscholar   +1 more source

Intervening After Trauma: Child–Parent Psychotherapy Treatment Is Associated With Lower Pediatric Epigenetic Age Acceleration

Psychology Science
Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers.
A. Sullivan, S. Merrill, Chaini Konwar, Michael Coccia, Luisa M. Rivera, Julia L. MacIsaac, Alicia F Lieberman, M. Kobor, Nicole R. Bush   +8 more
semanticscholar   +1 more source

GrimAge and GrimAge2 Age Acceleration effectively predict mortality risk: a retrospective cohort study

Epigenetics
Epigenetic clocks have been widely applied to assess biological ageing, with Age Acceleration (AA) serving as a key metric linked to adverse health outcomes, including mortality.
Tieshi Zhu, Yong He, Yixi Wang, Le Zhao
doaj   +1 more source

Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST).

Osteoarthritis and Cartilage
PURPOSE Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA.
M. Yau, P. Okoro, I. K. Haugen, J. Lynch, M. Nevitt, Cora E. Lewis, J. Torner, D. Felson   +7 more
semanticscholar   +1 more source