Results 161 to 170 of about 36,790 (258)

Mechanisms of Mucoid Degeneration in the Cruciate Ligament: Role of Denatured Aggrecan Accumulation and Tissue Dysfunction. [PDF]

Orthop Res Rev
Inoue A.
europepmc   +1 more source

Early Post‑Traumatic Osteoarthritis Features Greater Cartilage Extracellular Matrix Proteoglycan Loss Compared to the Pericellular Matrix

Journal of Orthopaedic Research, Volume 44, Issue 5, May 2026.
ABSTRACT Proteoglycan loss in articular cartilage is a hallmark of post‐traumatic osteoarthritis, and it can affect both chondrocyte biomechanics and tissue health. Previously, we found that 4 weeks after anterior cruciate ligament transection (ACLT) in rabbits, proteoglycan loss was less pronounced in the pericellular matrix (PCM) than in the ...
Rasmus K. Hiltunen, Nina Pesonen, Simo P. Ojanen, Mikko A. J. Finnilä, Sanna Palosaari, Walter Herzog, Simo Saarakkala, Rami K. Korhonen, Juuso T. J. Honkanen, Petri Tanska   +9 more
wiley   +1 more source

The Effect of Curcumin Treatment on Healing in a Rat Distal Femoral Osteochondral Defect Model. [PDF]

Cartilage
Balcı EC, Alagöz E, Acar A, Uslu M, Biçer O, Öztürk A, Başer E, Yaprak Bayrak B.   +7 more
europepmc   +1 more source

Human α2‐Macroglobulin: Architecture, Mechanisms, and Functional Implications

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Visual representation of human α2‐macroglobulin in its native and induced conformations. General functions associated with the native form (green), the induced form (white), and both conformations (light red) are indicated. ABSTRACT α2‐Macroglobulin (α2M) is a large glycoprotein and one of the most abundant proteins found in the plasma of vertebrates ...
Pietro de Carvalho Andrade, Tales Alexandre Costa‐Silva, Gisele Monteiro   +2 more
wiley   +1 more source

CircFN1 modulates IL-1β-induced osteoarthritis through the miR-19b-3p/PTEN signaling axis. [PDF]

Sci Rep
Jiang Y, Wang Q, Yang X, Liu H, Wu H, Wang M, Pan L, Cao Y, Meng Z.   +8 more
europepmc   +1 more source

p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Intraarticular injection of lentiviral p21 shRNA (targeting Cdkn1a) into murine knees with full‐thickness cartilage defects reduces chondrocyte senescence while enhancing matrix repair with minimal hepatic off‐target effects. ABSTRACT Focal articular cartilage defects lack intrinsic regenerative capacity and can progress to osteoarthritis as no ...
Leila Larijani, Aria Ahadzadeh Ardebili, Nini Ortiz Vales, Andreas T. Stürmer, Roman J. Krawetz   +4 more
wiley   +1 more source

Mitochondrial 8-Oxoguanine DNA Glycosylase 1-Mitochondrial Permeability Transition Pore Axis Drives Mitochondrial DNA Escape and Accelerates Osteoarthritis Progression. [PDF]

Research (Wash D C)
Huang S, Yu H, Qi W, Lin N, Chen J, Huang H, Hu P, Zhou Z, Zhang M, Ruan G, Xue S, Ding C.   +11 more
europepmc   +1 more source

PRKACB Attenuates Chondrocyte Loss and Inflammation in Osteoarthritis. [PDF]

Immun Inflamm Dis
Xiao W, Liu Z, Zhang Q.
europepmc   +1 more source

Fermented <i>Clostridium butyricum</i> GKB7 Inhibits Osteoarthritis Induced by Anterior Cruciate Ligament Transection in a Preclinical Model. [PDF]

Int J Med Sci
Chen WC, Chen LC, Tsai YS, Chen YP, Chen YL, Chen CC, Lin YY, Chang TC, Su CM, Tang CH.   +9 more
europepmc   +1 more source

Circulating Aggrecan, Biglycan, and Decorin as Biomarkers of Osteoarticular Alterations in Juvenile Idiopathic Arthritis-A Preliminary Study. [PDF]

Int J Mol Sci
Kuźnik-Trocha K, Winsz-Szczotka K, Olczyk K, Gruenpeter A, Komosińska-Vassev K.   +4 more
europepmc   +1 more source