Results 161 to 170 of about 21,356 (208)
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Matrix Biology, 1994
Large proteoglycans were purified by ion-exchange chromatography, gel filtration and CsCl gradient centrifugation from the compressed and tensional regions of adult bovine deep flexor tendon. Tryptic peptide maps of proteoglycan from the compressed region were very similar to maps of aggrecan from bovine articular cartilage, with evidence for the ...
K G, Vogel +3 more
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Large proteoglycans were purified by ion-exchange chromatography, gel filtration and CsCl gradient centrifugation from the compressed and tensional regions of adult bovine deep flexor tendon. Tryptic peptide maps of proteoglycan from the compressed region were very similar to maps of aggrecan from bovine articular cartilage, with evidence for the ...
K G, Vogel +3 more
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Journal of Bone and Mineral Metabolism, 2000
terminal globular (G)1 domain and a C-terminal G3 domain that are joined by intervening nonglobular sequences of lengths characteristic for each core protein. In addition, the aggrecan core protein has a G2 domain. The G1, G2, and G3 domains each contain distinctive motifs, with each motif having its own folded structure (Fig. 1).
W, Luo +6 more
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terminal globular (G)1 domain and a C-terminal G3 domain that are joined by intervening nonglobular sequences of lengths characteristic for each core protein. In addition, the aggrecan core protein has a G2 domain. The G1, G2, and G3 domains each contain distinctive motifs, with each motif having its own folded structure (Fig. 1).
W, Luo +6 more
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Aggrecan: Beyond cartilage and into the brain
The International Journal of Biochemistry & Cell Biology, 2012Aggrecan is well-studied in cartilage but its expression and function in the central nervous system has only recently begun to be appreciated. Aggrecan plays an important role in the organization of the neural extracellular space by binding and organizing hyaluronan to the cell surface through interactions with link protein and tenascins forming a ...
Morawski, M. +3 more
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Synthesis and characterization of an aggrecan mimic
Acta Biomaterialia, 2012Aggrecan (AGG) is a large, aggregating proteoglycan present throughout the body, but predominantly found in articular cartilage. The principle features of AGG, its hyaluronan (HA) binding domain and its abundance of covalently attached glycosaminoglycans (GAGs), make it an essential component of the functional ability of articular cartilage.
Jonathan C, Bernhard, Alyssa, Panitch
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Trends in Cell Biology, 1995
Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan.
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Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan.
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Solution Structure and Dynamics of Cartilage Aggrecan
Biomacromolecules, 2006We studied the structure and dynamics of porcine laryngeal aggrecan in solution using a range of noninvasive techniques: dynamic light scattering (DLS), small-angle neutron scattering (SANS), video particle tracking (VPT) microrheology, and diffusing wave spectroscopy (DWS).
Papagiannopoulos, A. +3 more
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Compressive nanomechanics of opposing aggrecan macromolecules
Journal of Biomechanics, 2006In this study, we have measured the nanoscale compressive interactions between opposing aggrecan macromolecules in near-physiological conditions, in order to elucidate the molecular origins of tissue-level cartilage biomechanical behavior. Aggrecan molecules from fetal bovine epiphyseal cartilage were chemically end-grafted to planar substrates ...
Alan J Grodzinsky +2 more
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Aggrecan degradation in osteoarthritis and rheumatoid arthritis
Acta Orthopaedica Scandinavica, 1995Aggrecan turnover is critically important to maintain extracellular matrix homeostasis in articular cartilage. Cartilage aggrecan metabolism has been studied in chondrocyte cell cultures, cartilage explant cultures, and in whole animal models. In many of these studies, matrix metalloproteinases (MMPs) are proposed to degrade cartilage aggrecan.
M W, Lark, E K, Bayne, L S, Lohmander
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Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review
Journal of International Medical Research, 2008 Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the ‘A Disintegrin And Metalloproteinase with ThromboSpondin motifs’ (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible
K, Huang, L D, Wu
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Journal of Rheology, 2002
Aggrecan is the self-assembling proteoglycan complex whose physiological function is to provide a hydrated gel in cartilage that stabilizes the spatial distribution of the collagen fibers, and absorbs and resists compressive loads. The linear and nonlinear viscoelastic behavior of aggrecan solutions was studied as a function of aggrecan concentration ...
Nispa Meechai +4 more
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Aggrecan is the self-assembling proteoglycan complex whose physiological function is to provide a hydrated gel in cartilage that stabilizes the spatial distribution of the collagen fibers, and absorbs and resists compressive loads. The linear and nonlinear viscoelastic behavior of aggrecan solutions was studied as a function of aggrecan concentration ...
Nispa Meechai +4 more
openaire +1 more source