Results 171 to 180 of about 21,330 (209)
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Synthesis and characterization of an aggrecan mimic
Acta Biomaterialia, 2012Aggrecan (AGG) is a large, aggregating proteoglycan present throughout the body, but predominantly found in articular cartilage. The principle features of AGG, its hyaluronan (HA) binding domain and its abundance of covalently attached glycosaminoglycans (GAGs), make it an essential component of the functional ability of articular cartilage.
Jonathan C, Bernhard, Alyssa, Panitch
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Solution Structure and Dynamics of Cartilage Aggrecan
Biomacromolecules, 2006We studied the structure and dynamics of porcine laryngeal aggrecan in solution using a range of noninvasive techniques: dynamic light scattering (DLS), small-angle neutron scattering (SANS), video particle tracking (VPT) microrheology, and diffusing wave spectroscopy (DWS).
Papagiannopoulos, A. +3 more
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Compressive nanomechanics of opposing aggrecan macromolecules
Journal of Biomechanics, 2006In this study, we have measured the nanoscale compressive interactions between opposing aggrecan macromolecules in near-physiological conditions, in order to elucidate the molecular origins of tissue-level cartilage biomechanical behavior. Aggrecan molecules from fetal bovine epiphyseal cartilage were chemically end-grafted to planar substrates ...
Delphine Dean +2 more
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Trends in Cell Biology, 1995
Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan.
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Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan.
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Aggrecan degradation in osteoarthritis and rheumatoid arthritis
Acta Orthopaedica Scandinavica, 1995Aggrecan turnover is critically important to maintain extracellular matrix homeostasis in articular cartilage. Cartilage aggrecan metabolism has been studied in chondrocyte cell cultures, cartilage explant cultures, and in whole animal models. In many of these studies, matrix metalloproteinases (MMPs) are proposed to degrade cartilage aggrecan.
M W, Lark, E K, Bayne, L S, Lohmander
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Journal of Rheology, 2002
Aggrecan is the self-assembling proteoglycan complex whose physiological function is to provide a hydrated gel in cartilage that stabilizes the spatial distribution of the collagen fibers, and absorbs and resists compressive loads. The linear and nonlinear viscoelastic behavior of aggrecan solutions was studied as a function of aggrecan concentration ...
Nispa Meechai +4 more
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Aggrecan is the self-assembling proteoglycan complex whose physiological function is to provide a hydrated gel in cartilage that stabilizes the spatial distribution of the collagen fibers, and absorbs and resists compressive loads. The linear and nonlinear viscoelastic behavior of aggrecan solutions was studied as a function of aggrecan concentration ...
Nispa Meechai +4 more
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Complete sequencing and characterization of equine aggrecan
Veterinary and Comparative Orthopaedics and Traumatology, 2015SummaryObjectives: To fully sequence and characterize equine aggrecan and confirm conservation of major aggrecanase, calpain and matrix metalloproteinase (MMP) cleavage sites.Methods: Reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends were used to generate clones that encompassed the complete equine aggrecan sequence ...
E H G, Caporali +2 more
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Mechanism of catabolism of aggrecan by articular cartilage
Archives of Biochemistry and Biophysics, 1992Characterization of aggrecan core protein peptides appearing in the medium of adult articular cartilage maintained in tissue culture showed that eight major peptides could be detected. The two largest peptides had the same N-terminal sequence as bovine aggrecan core protein and probably represent partly degraded aggrecan lost to the medium in the form ...
M Z, Ilic +3 more
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Perspectives on developmental neurobiology, 1997
During development, the extracellular matrix (ECM) is a complex dynamic structure whose components and organization help to establish the requisite position and state of differentiation. Until recently, the large chondroitin sulfate proteoglycan, aggrecan, has been localized predominantly to skeletal tissue and considered a hallmark of cartilage ...
N B, Schwartz +4 more
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During development, the extracellular matrix (ECM) is a complex dynamic structure whose components and organization help to establish the requisite position and state of differentiation. Until recently, the large chondroitin sulfate proteoglycan, aggrecan, has been localized predominantly to skeletal tissue and considered a hallmark of cartilage ...
N B, Schwartz +4 more
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Aggrecan, aging and assembly in articular cartilage
Cellular and Molecular Life Sciences, 2005The primary function of articular cartilage to act as a self-renewing, low frictional material that can distribute load efficiently at joints is critically dependent upon the composition and organisation of the extracellular matrix. Aggrecan is a major component of the extracellular matrix, forming high molecular weight aggregates necessary for the ...
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