Results 181 to 190 of about 27,782 (234)

Statement of Retraction: Eleutheroside E alleviates cerebral ischemia-reperfusion injury in a 5-hydroxytryptamine receptor 2C (Htr2c)-dependent manner in rats. [PDF]

Bioengineered
europepmc   +1 more source

A phase II basket trial of vosoritide in children with RASopathies, ACAN, and NPR2 deficiency.

J Clin Endocrinol Metab
Dauber A, Zhang A, Shafaei N, Seaforth R, Pitner K, Dham N, Kanakatti Shankar R, Merchant N.   +7 more
europepmc   +1 more source

Compressive nanomechanics of opposing aggrecan macromolecules

Journal of Biomechanics, 2006
In this study, we have measured the nanoscale compressive interactions between opposing aggrecan macromolecules in near-physiological conditions, in order to elucidate the molecular origins of tissue-level cartilage biomechanical behavior. Aggrecan molecules from fetal bovine epiphyseal cartilage were chemically end-grafted to planar substrates ...
Alan Grodzinsky, Delphine Dean, Lin Han
exaly   +4 more sources

The Different Roles of Aggrecan Interaction Domains [PDF]

Journal of Histochemistry and Cytochemistry, 2012
The aggregating proteoglycans of the lectican family are important components of extracellular matrices. Aggrecan is the most well studied of these and is central to cartilage biomechanical properties and skeletal development. Key to its biological function is the fixed charge of the many glycosaminoglycan chains, that provide the basis for the ...
Anders Aspberg
exaly   +5 more sources

Degradation of cartilage aggrecan by collagenase-3 (MMP-13) [PDF]

FEBS Letters, 1996
Degradation of the large cartilage proteoglycan aggrecan in arthritis involves an unidentified enzyme aggrecanase, and at least one of the matrix metalloproteinases. Proteinase-sensitive cleavage sites in the aggrecan interglobular domain (IGD) have been
Vera Knauper, Karena Last, Amanda Fosang
exaly   +2 more sources