Results 31 to 40 of about 237,133 (291)

Klotho mice: a novel wound model of aged skin. [PDF]

, 2014
BackgroundAs the elderly population continues to expand, it becomes increasingly important to develop treatments to improve wound healing in the elderly.
Yamashita, Ken, Yamauchi, Makoto, Yotsuyanagi, Takatoshi, Young, David M   +3 more
core   +2 more sources

The emerging role of cellular senescence in renal diseases [PDF]

, 2020
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco, Chen, Rong, Francis, Heather, Glaser, Shannon, Li, Siwen, Li, Xuesen, Meng, Fanyin, Wan, Ying, Wu, Nan, Zhang, Chunmei, Zhou, Bingru, Zhou, Tianhao, Zou, Ping   +12 more
core   +1 more source

The Rbm38-p63 feedback loop is critical for tumor suppression and longevity. [PDF]

, 2018
The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop.
Chen, Mingyi, Chen, Xinbin, Flores, Elsa, Jiang, Yuqian, Xu, Enshun, Zhang, Jin   +5 more
core   +1 more source

Tissue-specific suppression of thyroid hormone signaling in various mouse models of aging [PDF]

, 2016
DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive.
Barnhoorn, S. (Sander), Boelen, A. (Anita), Bombardieri, C.R. (Cíntia R.), Brandt, R.M.C. (Renata), Darras, V.M. (Veerle), Dollé, M.E.T. (Martijn), Garinis, G.A. (George), Heerebeek, R. (Ramona) van, Hoeijmakers, J.H.J. (Jan), Horst, G.T.J. (Gijsbertus) van der, Kaptein, E. (Ellen), Kopchick, J.J. (John ), Krijger, R.R. (Ronald) de, Kwakkel, J. (Joan), List, E.O. (Edward O.), Medici, M. (Marco), Melis, J.P.M. (Joost), Ottaviani, A. (Alexandre), Peeters, R.P. (Robin), Pluijm, I. (Ingrid) van der, Toor, H. (Hans) van, Van Ham, W. (Willy), Vermeij, W.P. (Wilbert), Visser, T.J. (Theo), Visser, W.E. (Edward), Waard, M.C. (Monique) de, Zevenbergen, C. (Chantal)   +26 more
core   +1 more source

Premature aging in genetic diseases: what conclusions can be drawn for physiological aging

Frontiers in Aging
According to current views the major hallmarks of physiological aging may be subdivided into three categories, primary causes of cellular damage (genomic instability, telomere attrition, loss of proteostasis, epigenetic alterations and compromised ...
Filip Milosic, Markus Hengstschläger, Selma Osmanagic-Myers   +2 more
doaj   +1 more source

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Nature Communications, 2018
Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related ...
Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson   +17 more
doaj   +1 more source

Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review

Cells, 2021
Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic causative factors of aging. Intrinsic aging is related to compromised cellular proliferative capacity, and may be accelerated by harmful environmental ...
Angelika Bielach-Bazyluk, Edyta Zbroch, Hanna Mysliwiec, Alicja Rydzewska-Rosolowska, Katarzyna Kakareko, Iwona Flisiak, Tomasz Hryszko   +6 more
doaj   +1 more source

The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: a pilot study [PDF]

, 2018
Objective: To assess the efficacy and safety of an association of diallyl thiosulfinate with nuciferine and diosgenin in the treatment of a group of patients suffering from premature ejaculation (PE), primary or secondary to erectile dysfunction (ED ...
Cai, Tommaso, Carrino, Maurizio, Chiancone, Francesco, Cito, Gianmartin, Cocci, Andrea, Comerci, Francesco, Franco, Giorgio, Giammusso, Bruno, Mastroeni, Francesco, Palmieri, Alessandro, Zucchi, Alessandro   +10 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Cellular senescence - its role in cancer and the response to ionizing radiation [PDF]

, 2011
© 2011 Sabin and Anderson; licensee BioMed Central Ltd. This article is available through the Brunel Open Access Publishing Fund. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http ...
Anderson, RM, Sabin, RJ
core   +2 more sources