Results 41 to 50 of about 211,860 (282)
From the Rarest to the Most Common: Insights from Progeroid Syndromes into Skin Cancer and Aging [PDF]
, 2009 Despite their rarity, diseases of premature aging, or “progeroid” syndromes, have provided important insights into basic mechanisms that may underlie cancer and normal aging.
Capell, Brian C. +2 more
core +1 more source
Retinopathy of prematurity: age at onset. [PDF]
Archives of Disease in Childhood, 1986 The age at which retinopathy of prematurity was first seen was determined in 143 infants. In all, the initial ophthalmological examination was normal. Birth weights varied from 630 to 2700 g and gestational ages from 24.5 to 40.0 weeks. The median postnatal age at which acute retinopathy of prematurity was first seen was 51 and 40 days for those less ...
M I Levene, Y K Ng, A R Fielder
openaire +3 more sources
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome
Nature Communications, 2018 Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related ...
Gabriel Balmus +17 more
doaj +1 more source
Long-term exposure to polystyrene microplastics triggers premature testicular aging
Particle and Fibre Toxicology, 2023 Background Plastic pollution is greatly serious in the ocean and soil. Microplastics (MPs) degraded from plastic has threatened animals and humans health. The accumulation of MPs in the tissues and blood in animals and humans has been found.
Deyi Wu +3 more
doaj +1 more source
The premature ageing syndromes: insights into the ageing process [PDF]
Age and Ageing, 1998 Ageing in man results from a complex interaction of genetic and environmental factors. Many overlapping and sometimes conflicting theories of ageing exist and the emergence of a unified theory still seems unlikely. Experimental studies of senescence are difficult to design because of the variable effect of diseases and other extrinsic factors.
Christopher Dyer, Alan J. Sinclair
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra +17 more
wiley +1 more source
An aging evaluation of the bearing performances of glass fiber composite laminate in salt spray fog environment [PDF]
, 2019 The aim of the present paper is to assess the bearing performance evolution of pinned, glass-composite laminates due to environmental aging in salt-spray fog tests.
Bruzzaniti P. G. +4 more
core +1 more source
Translating Muscle RNAseq Into the Clinic for the Diagnosis of Muscle Diseases
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Approximately half of patients with hereditary myopathies remain without a definitive genetic diagnosis after DNA next‐generation sequencing (NGS). Here, we implemented transcriptome analysis of muscle biopsies as a complementary diagnostic tool for patients with muscle disease but no definitive genetic diagnosis after exome ...
Alba Segarra‐Casas +24 more
wiley +1 more source
Tissue-specific suppression of thyroid hormone signaling in various mouse models of aging [PDF]
, 2016 DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive.
Barnhoorn, S. (Sander) +26 more
core +1 more source
ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING
Radiation Protection Dosimetry, 2022 Abstract The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage–Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time.
Takahiro Wada +2 more
openaire +2 more sources