Results 61 to 70 of about 237,133 (291)
Frontiers in Cellular and Infection MicrobiologyBackgroundYin-deficiency constitution (YinDC) refers to a traditional Chinese medicine concept, characterized by an imbalance state that includes an imbalance in the gut microbiota, resulting from a relative deficiency of Yin fluids within the body.
Yingying Zhai +15 more
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The role of peroxisome proliferator-activated receptor-coactivator-1 gene in skin aging
Journal of Research in Medical Sciences, 2016 Skin aging is a continuous process that exhibits fine and deep wrinkles, thin and transparent skin, loss of underlying fat, dry skin and itch, following decreased collagen and elastin synthesis.
Shahrzad Aghaei +2 more
doaj +1 more source
Loss of αklotho causes reduced motor ability and short lifespan in zebrafish
Scientific Reports, 2021 The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone.
Yurie Ogura +4 more
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Social and medical aspects longevity [PDF]
, 2011 The article deals with the demographical problem's population aging, life expectancy, premature aging, are shown results on quality of life in countries in relation to different indexes, that form ...
Duque Kalderon, U. F. +3 more
core
Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise [PDF]
, 2011 The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy ...
Darzynkiewicz, Zbigniew +3 more
core +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Clinical and laboratory criteria for occult form of premature ovarian failure [PDF]
Гинекология, 2018 Purpose of the study. To develop clinical and laboratory criteria characteristic of the occult (hidden) form of premature ovarian failure. Material and methods.
L A Marchenko, R I Mashaeva
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Premature aging, allostasis and restorgenesis [PDF]
Spinal Cord, 2013 I feel that the highlight of my research activities is bringing the topic of ‘premature morbidity and aging’ (senectus praecox), in people with spinal cord injury (SCI) and other disabilities, into public awareness ...
openaire +2 more sources
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Molecular signatures of premature aging in Major Depression and Substance Use Disorders
Scientific DataMajor depressive disorder (MDD) and substance-use disorders (SUDs) often lead to premature aging, increasing vulnerability to cognitive decline and other forms of dementia. This study utilized advanced systems bioinformatics to identify aging “signatures”
Anna Onisiforou +2 more
doaj +1 more source