Results 121 to 130 of about 98,913 (262)

DEVELOPMENT OF NOVEL AHR ANTAGONISTS [PDF]

, 2010
Aryl hydrocarbon receptor (AHR) is a sensor protein, activated by aromatic chemical species for transcriptionally regulating xenobiotic metabolizing enzymes. AHR is also known to be involved in a variety of pathogenesis such as cancer, diabetes mellitus,
Lee, Hyosung
core  

The potential impact of H1 antihistamines on clinical outcomes in NSCLC patients undergoing EGFR‐TKIs treatment

British Journal of Clinical Pharmacology, EarlyView.
Background Epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) have substantially improved outcomes in non‐small cell lung cancer (NSCLC); however, the development of treatment resistance remains a major clinical challenge. This study examines the association between concomitant prescriptions of H1‐antihistamines (H1AHs) and ...
Van Thuan Nguyen, Ngoc Hoang Le, Nhu Quynh Phan, Toan Trung Duong, Le Thi Anh Thu, Hsuan‐Chia Yang, Chih‐Wei Huang, Min‐Huei Hsu, Jason C. Hsu, Chien‐Tien Su, Phung‐Anh Nguyen   +10 more
wiley   +1 more source

AhR expression in prostate cancer tissues.

, 2014
A. Representative Grade 1, Grade 2 and Grade 3 prostate cancer tissues: Upper panel stained with anti-AhR polyclonal antibody; lower panel stained with hematoxylin and eosin.
Oliver Richmond (585233), Cidney Allen (585235), Maryam Ghotbaddini (585234), Joann B. Powell (585238), Alice Walker (585236), Shokouh Zahir (585237)   +5 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

AhR sensing of bacterial pigments regulates antibacterial defence

, 2014
The aryl hydrocarbon receptor (AhR) is a highly conserved ligand-dependent transcription factor that senses environmental toxins and endogenous ligands, thereby inducing detoxifying enzymes and modulating immune cell differentiation and responses.
Krause, Gerd, Goosmann, C., Silke Bandermann, Hans-Joachim Mollenkopf, Tatsiana Skrahina, Kreuchwig, A., Skrahina, Tatsiana, Brinkmann, V., Bandermann, S., Fillatreau, S., Krause, G., Houthuys, E., Jens Furkert, Anne Diehl, Tümmler, Burkhard, Daffe, M., Michael Kolbe, Skrahina, T., Koehler, A., Hurwitz, Robert, Diehl, A., Moura-Alves, Pedro, Mamadou Daffe, Klemm, Marion, Faé, K., Hartmut Oschkinat, Annika Kreuchwig, Marion Klemm, Moura-Alves, P., Faé, Kellen, Tümmler, B., Robert Hurwitz, Stefan H. E. Kaufmann, Kellen Faé, Klemm, M., Daffe, Mamadou, Munder, A., Houthuys, Erica, Constant, P., Hurwitz, R., Mollenkopf, Hans-Joachim, Pedro Moura-Alves, Erica Houthuys, Barison, N., Mollenkopf, H., Munder, Antje, Kolbe, M., Nicola Barison, Furkert, J., Volker Brinkmann, Brinkmann, Volker, Anca Dorhoi, Burkhard Tümmler, Simon Fillatreau, Fillatreau, Simon, Oschkinat, Hartmut, Ute Guhlich-Bornhof, Patricia Constant, Furkert, Jens, Dorhoi, Anca, Goosmann, Christian, Koehler, Anne-Britta, Guhlich-Bornhof, U., Bandermann, Silke, Kaufmann, Stefan HE, Kreuchwig, Annika, Constant, Patricia, Christian Goosmann, Guhlich-Bornhof, Ute, Anne-Britta Koehler, Diehl, Anne, Antje Munder, Gerd Krause, Kolbe, Michael, Barison, Nicola, Kaufmann, S., Oschkinat, H., Dorhoi, A.   +77 more
core   +1 more source

The influence of circadian variables on ecotoxicology metabolomics

Biological Reviews, EarlyView.
ABSTRACT Ecotoxicologists are using metabolomics increasingly to gain insight into toxicological mechanisms and sublethal effects of chemical exposures. Metabolomics offers a sensitive multi‐parameter approach that can detect biochemical responses not obvious using apical and behavioural endpoints.
Ryan I. Lester, David J. Beale, Anthony R. Carroll, Steven D. Melvin   +3 more
wiley   +1 more source

Temporal Trends and Prognosis in Rotational Atherectomy: A Comparison of Contemporary and Traditional Eras

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Rotational atherectomy (RA) has undergone considerable technical modernization in recent years. This study evaluated whether RA performed in the contemporary era was associated with superior cardiovascular outcomes compared with the traditional era. Aims To compare the clinical characteristics and cardiovascular outcomes of patients
Ravi Vazirani, Gonzalo García‐Martí, Andrés Provencio‐Regidor, Irene Serrano‐García, Adrián Jerónimo‐Baza, Alejandro Travieso, Gabriela Tirado‐Conte, Fernando Macaya‐Ten, Hernán Mejía‐Rentería, Pablo Salinas, Luis Nombela‐Franco, Pilar Jiménez‐Quevedo, Nieves Gonzalo, Javier Escaned, Antonio Fernández‐Ortiz, Iván J. Núñez‐Gil   +15 more
wiley   +1 more source

Dual‐Function Electrocatalysis: Simultaneous Wastewater Remediation and Hydrogen Evolution—A Comprehensive Review

Carbon Energy, EarlyView.
Replacing the oxygen evolution reaction with the electro‐oxidation of pollutants and waste streams offers an energy‐efficient route for simultaneous hydrogen production and pollutant remediation. This review summarizes the reaction mechanisms, catalyst design principles, and emerging paired‐electrolysis strategies that govern activity, selectivity ...
Safa Al‐Yahyaey, Rashid Al‐Hajri, Ala'a H. Al‐Muhtaseb, Hussein A. Younus, Mohammed Al‐Abri   +4 more
wiley   +1 more source

Urogenital Infection Risk Associated With SGLT2 Inhibitors Versus DPP‐4 Inhibitors in Type 2 Diabetes and Chronic Kidney Disease: A Nationwide Target Trial Emulation

Clinical Pharmacology &Therapeutics, EarlyView.
Although sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), concerns regarding urogenital infections persist. Therefore, we evaluated the risk of urinary tract infection (UTI) and genital tract infection (GTI) after SGLT2i initiation in this population ...
Young‐Mi Ah, Junsung Nam, Jung Wook Youn, Yun Mi Yu, Soyoung Kang   +4 more
wiley   +1 more source

Cross-regulatory Circuit Between AHR and Microbiota

, 2019
Background: The gut microbes have a close symbiotic relationship with their host. Interactions between host and the microbiota affect the nutritional, immunological, and physiological status of the host.
Jian Ji, Hao Qu
core   +1 more source