Results 121 to 130 of about 13,748 (218)

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye [PDF]

, 2016
Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Loss of retinal pigment epithelium (RPE) is a major pathological hallmark in AMD with or without pathological neovascularization.
Allakhverdi, Barbour, Bell, Campbell, Carriere, Carver, Cayrol, Chackerian, Chen, Chen, Choi, Daniels, Demyanets, Dick, Doyle, Doyle, Doyle, Dunn, Forrester, Friedlander, Fu, Guidry, Kakkar, Kuchler, Lamkanfi, Lamkanfi, Lavalette, Lefrancais, Leung, Liew, Liu, Luthi, Martin, McMenamin, Miller, Nussenblatt, Oboki, Pichery, Rein, Schmitz, Wei, Wu, Xi, Xu, Xu, Xu, Xu, Yanagisawa   +47 more
core   +3 more sources

Prothymosinα, as a neuroprotective DAMPs/Alarmins molecule

Folia Pharmacologica Japonica, 2018
Prothymosin alpha (ProTα) has been identified as an anti-necrotic factor from the conditioned medium of primary cultured of rat cortical neurons under the serum-free starving condition. ProTα is released in a non-vesicular manner from neurons or astrocytes by the help of cargo protein S100A13.
Hiroshi, Ueda, Shiori, Maeda
openaire   +3 more sources

Chromatin as alarmins in necrotizing enterocolitis

Frontiers in Immunology
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease primarily affecting premature neonates, marked by poorly understood pro-inflammatory signaling cascades. Recent advancements have shed light on a subset of endogenous molecular patterns, termed chromatin-associated molecular patterns (CAMPs), which belong to the broader category of ...
Colleen P. Nofi, Colleen P. Nofi, Colleen P. Nofi, Jose M. Prince, Jose M. Prince, Ping Wang, Ping Wang, Ping Wang, Ping Wang, Monowar Aziz, Monowar Aziz, Monowar Aziz, Monowar Aziz   +12 more
openaire   +3 more sources

Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation

European Journal of Immunology, Volume 56, Issue 4, April 2026.
Inhaled pretreatment of mouse lungs with immunomodulatory Pam2ODN results in lung epithelial cell epigenetic reprogramming that is associated with attenuation of house dust mite extract (HDM)‐induced cDC2s and moDCs expansion in the lung, causing tolerance against HDM sensitization and restricting Th2‐cell‐induced airway eosinophilic allergic ...
Mbaya Ntita, Celine Shuet Lin Kong, Dalia Hassan, Richa Nayak, Jezreel Pantaleón García, Yongxing Wang, Jichao Chen, Scott E. Evans   +7 more
wiley   +1 more source

Serum high mobility group box protein 1 (HMGB1) levels reflect clinical features of childhood hemophagocytic lymphohistiocytosis

Journal of Blood Medicine, 2019
Hiroshi Tsujimoto, Shinji Kounami, Takayuki Ichikawa, Taketsugu Hama, Hiroyuki SuzukiDepartment of Pediatrics, Wakayama Medical University, Wakayama, JapanCorrespondence: Hiroshi TsujimotoDepartment of Pediatrics, Wakayama Medical University, 811-1 ...
Tsujimoto H, Kounami S, Ichikawa T, Hama T, Suzuki H   +4 more
doaj  

Relationship Between Bronchodilator Reversibility and Spirometry Response to Dupilumab in Type 2 High Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 253-255, March 2025.
Robert Greig, Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth   +4 more
wiley   +1 more source

ILC2s chew the fat. [PDF]

, 2019
In this issue of JEM, Rana et al. (https://doi.org/10.1084/jem.20190689) report that adipose tissue multipotent stromal cells (MSCs) provide multifaceted support for adipose tissue-resident ILC2s through contact-mediated proliferation and IL-33-mediated ...
Locksley, Richard M, Ricardo-Gonzalez, Roberto R   +1 more
core   +1 more source

Tezepelumab Reduces Alarmin Cytokine Levels in Upper Airway Epithelial Cells in Patients With Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Hazel Marriott, Adil Adatia, Subhabrata Moitra, Paige Lacy   +3 more
wiley   +1 more source

The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation

Allergy, Volume 81, Issue 4, Page 1173-1192, April 2026.
Farm dust extract (FDE) treatment reduces airway eosinophilia, mucus overproduction, and MHC‐II expression on DCs, limiting antigen presentation and Th2 inflammation. It increases PD‐L1 on DCs, promoting T cell deactivation. Additionally, FDE enhances Tregs and upregulates CTLA‐4, reinforcing suppression.
Rabia Ülkü Korkmaz, Jimmy Omony, Xiaomei Tan, Markus Klotz, Guilherme Dragunas, Sirui Chen, Soni Shankhwar, Zeynep Ertüz, Christoph Müller, Mohab Ragab, Aicha Jeridi, Romina Augustin, Janna Nawroth, Theodore S. Kapellos, Bettina Rankl, Ali Önder Yildirim, Erika von Mutius   +16 more
wiley   +1 more source