Results 251 to 260 of about 196,000 (337)

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Characterization of the GTPγS release function of a G protein-coupled receptor. [PDF]

Nat Commun
Bohn LM, Stahl EL.
europepmc   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Modular Synthesis of Substituted Lactams via a Deoxygenative Photochemical Alkylation-Cyclization Cascade of Secondary Amides in Flow. [PDF]

JACS Au
Diprima D, Paulsen TT, Pulcinella A, Bonciolini S, Gabbey AL, Stuhr R, Poulsen TB, Noël T.   +7 more
europepmc   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Efficient Radical‐Mediated Intermolecular α‐Alkylation Reactions of Carbonyl Compounds with Nonactivated Alkenes

Yasuhiro Yamashita, Shu̅ Kobayashi
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization. [PDF]

Nat Commun
Nippa DF, Atz K, Stenzhorn Y, Müller AT, Tosstorff A, Benz J, Binch H, Bürkler M, Haider A, Heer D, Hochstrasser R, Kramer C, Reutlinger M, Schneider P, Shema T, Topp A, Walter A, Wittwer MB, Wolfard J, Kuhn B, van der Stelt M, Martin RE, Grether U, Schneider G.   +23 more
europepmc   +1 more source

Multiple‐Use Microplate Assay for Submicromolar Ultra High‐Throughput Separation of Amines Based on their Degree of Substitution

ChemistryOpen, EarlyView.
A reusable microplate platform for ultra‐high‐throughput, submicromolar separation of protonated amines – including alkyl‐, aryl‐, and aralkyl‐types – using a tris(pyridino)‐crown ether selector was introduced; the method enables rapid, zero‐energy, parallel purification fully compatible with automated synthesis workflows.
Panna Vezse, Tünde Tóth, Péter Huszthy, Ádám Golcs   +3 more
wiley   +1 more source

Single-Step Synthesis of 1,2-Cyclopentanediones by Dehydrogenative Annulation of Ethylene Glycol with Secondary Alcohols. [PDF]

J Am Chem Soc
Lu L, Luo J, Montag M, Diskin-Posner Y, Milstein D.   +4 more
europepmc   +1 more source