Results 61 to 70 of about 10,332 (223)

Asymmetric Decarboxylative Allylation of Oxindoles [PDF]

, 2011
An asymmetric decarboxylative palladium-catalyzed allylation of alkyl- and aryl-substituted oxindoles has been developed, enabling the installation of an all-carbon quaternary chiral center at the oxindole 3-position in excellent yields and good to ...
Mark Pickworth, Franckevicius, Vilius, Vilius Franckevičius, Richard J. K. Taylor, James D. Cuthbertson, David S. Pugh, Taylor, Richard J. K., Pickworth, Mark, Cuthbertson, James D., Pugh, David S.   +9 more
core   +1 more source

(E)-2-(1,3-Diphenylallyl)-3,5-dimethoxyphenol

Molbank, 2023
The synthesis of (E)-2-(1,3-diphenylallyl)-3,5-dimethoxyphenol is described by means of the reaction of 3,5-dimethoxyphenol with (E)-1,3-diphenylprop-2-en-1-ol in 1,1,1,3,3,3-hexafluoroispropanol (HFIP), which acts as a solvent and reaction promoter. The
Lara Mollà-Guerola, Alejandro Baeza
doaj   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, EarlyView.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Total syntheses of the parvistemoline alkaloids enabled by stereocontrolled Ir/Pd-catalyzed allylic alkylation

Nature Communications
The functionalized polycycle with densely contiguous tertiary stereocenters is a formidable challenge in synthesizing the parvistemoline family of Stemona alkaloids.
Xiao Liang, Qian-Hui Ding, Jian-Ting Yang, Hua-Fei Yang, Yi Deng, Li Shi, Kun Wei, Yu-Rong Yang   +7 more
doaj   +1 more source

Iridium Catalyzed Enantioselective Intermolecular Indole C2-Allylation [PDF]

, 2020
The enantioselective intermolecular C2-allylation of 3-substituted indoles is reported for the first time. This directing group-free approach relies on a chiral Ir-(P, olefin) complex and Mg(ClO4)2 Lewis acid catalyst system to promote allylic ...
Zheng, Chao, Clarke, Aimee K, Aimee K. Clarke, William P. Unsworth, Chao Zheng, Donald, James R, You, Shu-Li, Rossi-Ashton, James A, Shu‐Li You, Richard J. K. Taylor, James A. Rossi‐Ashton, James R. Donald, Unsworth, William Paul, Taylor, Richard J K   +13 more
core   +1 more source

New Concept in the Allylation of Aldehydes:  Regiospecific Allylation of Aldehydes by an Allyl-Transfer Reaction of Homoallylic Alcohols [PDF]

, 2016
New Concept in the Allylation of Aldehydes:  Regiospecific Allylation of Aldehydes by an Allyl-Transfer Reaction of Homoallylic ...
Hiroyuki Matsuura (3004563), Shin-ichi Sumida (3004560), Kenji Yoshizane (3004557), Junzo Nokami (2677924)   +3 more
core   +1 more source

Synthesis of indole-based propellane derivatives via Weiss–Cook condensation, Fischer indole cyclization, and ring-closing metathesis as key steps

Beilstein Journal of Organic Chemistry, 2013
A variety of highly functionalized indole-based [n.3.3]propellane derivatives is described. The synthesis of the propellane derivatives involves a Weiss–Cook condensation, a Fischer indole cyclization, and a ring-closing metathesis as key steps.
Sambasivarao Kotha, Ajay Kumar Chinnam, Arti Tiwari   +2 more
doaj   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Studies towards the synthesis of hyperireflexolide A

Beilstein Journal of Organic Chemistry, 2018
The first approach to hyperireflexolide A, based on the synthesis of γ-lactone-fused cyclopentane 5, a functionalized key intermediate, is presented. Compound 5 is involved in hydrolysis, α-allylation at C-8 and α-methylation at C-10 stereoselectively ...
G. Hari Mangeswara Rao
doaj   +1 more source

A Ruthenium‐(Ph‐BPE) Catalyst for Asymmetric Alkynylation of Fluoral: Enantioselection From 1 of 12 Fluxional Stereogenic‐at‐Ruthenium Complexes

Angewandte Chemie International Edition, Volume 65, Issue 30, 20 July 2026.
The first enantioselective alkynylations of aqueous fluoral are described. These processes are catalyzed by an iodide‐bound ruthenium‐(Ph‐BPE)‐catalyst; an octahedral metal complex that can exist as 12 diastereomeric‐at‐metal isomers. Calculations reveal that 2 of 12 stereoisomeric complexes account for 99.9% of the Boltzmann population and that ...
Weijia Shen, Sebastian Höthker, Colin E. Hayter, Nicholas K. Bowers, Andrea Pellegrini, Stefan Grimme, Michael J. Krische   +6 more
wiley   +1 more source