Results 61 to 70 of about 17,659 (225)

Desymmetrization of Pseudo‐para Diformyl[2.2]Paracyclophane via Brønsted Acid‐Catalyzed Reductive Amination

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
A highly stereoselective desymmetrization of pseudo‐para diformyl[2.2]paracyclophanes is developed via chiral Brønsted acid‐catalyzed reductive amination. This protocol provides efficient access to enantiopure planar chiral paracyclophanes with broad substrate scope, excellent enantioselectivity, and versatile postsynthetic functionalization. Access to
Sandip Baban Shinde, Martin Kamlar, Vojtěch Dočekal, Ivana Císařová, Jan Veselý   +4 more
wiley   +1 more source

(E)-2-(1,3-Diphenylallyl)-3,5-dimethoxyphenol

Molbank, 2023
The synthesis of (E)-2-(1,3-diphenylallyl)-3,5-dimethoxyphenol is described by means of the reaction of 3,5-dimethoxyphenol with (E)-1,3-diphenylprop-2-en-1-ol in 1,1,1,3,3,3-hexafluoroispropanol (HFIP), which acts as a solvent and reaction promoter. The
Lara Mollà-Guerola, Alejandro Baeza
doaj   +1 more source

Gold(I)-Catalysed Direct Thioetherifications Using Allylic Alcohols: an Experimental and Computational Study [PDF]

, 2014
A gold(I)-catalysed direct thioetherification reaction between allylic alcohols and thiols is presented. The reaction is generally highly regioselective (S(N)2′).
Barker, Graeme, Green, Samantha L. J., Herkert, Lorena, Johnson, David G., Lee, Ai-lan, Macgregor, Stuart A., Young, Paul C.   +6 more
core   +1 more source

Design, Synthesis, and Structural Analysis of Binaphthyl‐Based Chiral Benzindenes

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
This work explores the synthetic endeavors in constructing the first‐of‐a‐kind axially chiral benz[f]indenes as potential chiral ligands. The overall synthetic pathway spans across 9 steps with 15.9% overall yield. Challenges in constructing modified analogs as well as metal complexes are discussed. Chiral benzindenes are an unexplored structural motif
Marko Gobin, Nikola Topolovčan
wiley   +1 more source

Total syntheses of the parvistemoline alkaloids enabled by stereocontrolled Ir/Pd-catalyzed allylic alkylation

Nature Communications
The functionalized polycycle with densely contiguous tertiary stereocenters is a formidable challenge in synthesizing the parvistemoline family of Stemona alkaloids.
Xiao Liang, Qian-Hui Ding, Jian-Ting Yang, Hua-Fei Yang, Yi Deng, Li Shi, Kun Wei, Yu-Rong Yang   +7 more
doaj   +1 more source

Deacylative Allylation: Allylic Alkylation via Retro-Claisen Activation [PDF]

Journal of the American Chemical Society, 2011
A new method for allylic alkylation of a variety of relatively nonstabilized carbon nucleophiles is described herein. In this process of "deacylative allylation", the coupling partners, an allylic alcohol and a ketone pronucleophile, undergo in situ retro-Claisen activation to generate an allylic acetate and a carbanion.
Grenning, Alexander J., Tunge, Jon A.
openaire   +3 more sources

Highly Lewis Acidic In Situ‐Generated Boronic Acid Ester: A Practical Catalyst for Hosomi–Sakurai Conjugate Addition, Carbonyl‐Ene Reaction, and Silane‐Mediated Amide Reduction

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
An exceptionally Lewis acidic boronic acid ester, generated in situ from pentafluorophenylboronic acid and tetrabromonaphthalenediol, catalyzes three important chemical transformations at 1–10 mol% loading: the Hosomi–Sakurai allylation of α,β‐unsaturated ketones, intermolecular carbonyl‐ene reactions, and the reductions of tertiary amides to amines ...
Ava Bousselat, Elisabeth Bats, Charbel Alkazzi, Karine Jarsale, Jacques Rouden, Jérôme Blanchet   +5 more
wiley   +1 more source

Rhodium‐Catalyzed Regioselective Addition of N‐Hydroxyl Imides to Internal Alkynes

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
An intermolecular rhodium‐catalyzed regioselective addition of N‐hydroxyl imides to internal alkynes leads to branched O‐allyl compounds, which can be readily transformed to allylic alcohols and O‐allyl hydroxylamines after deprotection. Isotopic labelling experiments suggest a plausible reaction mechanism.
Zi Liu, Bernhard Breit
wiley   +1 more source

Synthesis of indole-based propellane derivatives via Weiss–Cook condensation, Fischer indole cyclization, and ring-closing metathesis as key steps

Beilstein Journal of Organic Chemistry, 2013
A variety of highly functionalized indole-based [n.3.3]propellane derivatives is described. The synthesis of the propellane derivatives involves a Weiss–Cook condensation, a Fischer indole cyclization, and a ring-closing metathesis as key steps.
Sambasivarao Kotha, Ajay Kumar Chinnam, Arti Tiwari   +2 more
doaj   +1 more source

From the Modeling of Experiments to the Ab Initio Prediction of Rate Constants: Statistical Rate Theory for a Quantitative Understanding of Gas‐Phase Ion Chemistry

ChemPhysChem, Volume 27, Issue 8, 28 April 2026.
For directly comparing experimental results on gas‐phase ion reactions with the predictions from quantum chemical calculations, the latter must first be converted into rate constants. This review addresses the question of whether current methods of statistical rate theory can accomplish this task reliably. Statistical rate theory has long been used for
Thomas Auth, Konrad Koszinowski
wiley   +1 more source