Alpha‐Lipoic Acid Reduces NLRP3/ASC Expression and IL‐1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium [PDF]
Food Sci NutrAlpha‐lipoic acid (ALA) reduced NLRP3/ASC expression, attenuated upstream NF‐κB/ERK signaling, and decreased IL‐1β release while preserving mitochondrial membrane potential in murine Kupffer cells subjected to LPS priming and a second signal. Conditioned medium from ALA‐pretreated Kupffer cells (particularly 100 μM) enhanced glucose uptake and improved
Ko C +6 more
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Toxicology Reports, 2018 This study was carried out to determine the changes in the lungs of the rat pups exposed to tobacco smoke during pregnancy period and to investigate the protective effects of alpha lipoic acid, which is administered during pregnancy, on these changes ...
Elif Erdem Guzel +5 more
doaj +2 more sources
Synergistic antihyperglycemic effect of alpha lipoic acid with antidiabetic agents in the normoglycemic and streptozotocin-induced type 2 diabetic rats [PDF]
Acta Poloniae Pharmaceutica, 2023 The current study's main goal was to assess the supplementation effect of alpha lipoic acid with antidiabetic medications (metformin and sitagliptin) on normal and streptozotocin-induced blood glucose levels in normal and streptozotocin-induced diabetic ...
Rawsan Ali Sabri +2 more
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SVU-International Journal of Veterinary Sciences, 2022 Background: Pharmacological and toxicological challenges are among the most important studies in revealing the latent properties of drugs Objective: the goal of this study was to evaluate the effects of alpha-lipoic acid on the central nervous system ...
Marwa Abdul-Ghani, Ahmed Naser
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The protective impacts of lipoic acid on diclofenac-induced hepatorenal toxicity in broiler chicks [PDF]
Iraqi Journal of Veterinary Sciences, 2022 Alpha-lipoic acid is an anti-inflammatory and antioxidant compound that shows free radical scavenging actions and potent antioxidant properties on the metabolites of other cellular oxidants.
Marwa R. Abdul-Ghani, Ahmed S. Naser
doaj +1 more source
Animals, 2021 Alpha-lipoic acid (a-LA) is used as a nutritive additive in dog food. Therefore, we performed a systematic review of studies published to date in PubMed, Google Scholar, Cochrane Library and MedlinePlus involving alpha-lipoic acid supplementation, which ...
Reshma M. Anthony +2 more
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Effect of Alpha-Lipoic Acid on the Characteristics and Physical Stability of NLC-Green Tea Extract
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2022 Background: The addition of alpha-lipoic acid in Nanostructured Lipid Carrier-Green Tea Extract (NLC-GTE) has potential to increase effectiveness of anti-aging preparations.
Fairuz Yaumil Afra +2 more
doaj +1 more source
Evaluation of the neuroprotective effects of alpha lipoic acid-loaded folate-conjugated chitosan nanoparticles against 6-OHDA-induced apoptosis and oxidative stress in an in vitro Parkinson's disease model. [PDF]
BMC NeurosciGheybi E +5 more
europepmc +2 more sources
Estimation of pharmacokinetic parameters of alpha-lipoic acid in the chicks model
Baghdad Journal of Biochemistry and Applied Biological Sciences, 2022 Background and objective: Alpha-lipoic acid is a drug used to treat diabetic neuropathy, and it has other uses as a dietary supplement. The target of the study was to investigate the concentration of therapeutic doses of Alpha-lipoic acid in the blood ...
Marwa R. Abdulghani, Ahmed S. Naser
doaj +1 more source
Качественная клиническая практика, 2021 Rational pharmacotherapy in the Program of Preferential Medicinal Providing can be implemented subject to high-quality information support from healthcare professionals.
E. V. Eliseeva +4 more
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