Diabetes and alpha lipoic acid [PDF]
Frontiers in Pharmacology, 2011 Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative stress that contributes to the pathogenesis of this debilitating disease.
Issy eLaher
doaj +3 more sources
Dietary Alpha-Lipoic Acid Alters Piglet Neurodevelopment [PDF]
Frontiers in Pediatrics, 2016 Alpha-lipoic acid (a-LA) is an antioxidant shown to ameliorate age-associated impairments of brain and cardiovascular function. Human milk is known to have high antioxidant capacity; however, the role of antioxidants in the developing brain is largely uncharacterized.
Austin T Mudd +7 more
openaire +5 more sources
Activity of serum paraoxonase 1, lipid profile and atherogenic indexes in diabetic induced rats treated with alpha lipoic acid [PDF]
Journal of Nephropathology, 2018 Background: Paraoxonase 1 (PON1) is an enzyme attached to high density lipoprotein (HDL-C) which has antioxidant and anti-atherogenic activities. Objectives: In this study, we investigated the effects of alpha lipoic acid on PON1 activity, lipid profile ...
Parisa Jamor +3 more
doaj +1 more source
Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
Animals, 2021 This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated ...
Reshma M. Anthony +4 more
doaj +1 more source
A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells. [PDF]
, 2015 Aging is characterized by a progressive deterioration in physiological functions and metabolic processes. The loss of cells during aging in vital tissues and organs is related to several factors including oxidative stress and inflammation.
Borsani, Elisa +7 more
core +1 more source
From discovery to scale-up: alpha-lipoic acid : nicotinamide co-crystals in a continuous oscillatory baffled crystalliser [PDF]
, 2014 The crystalline nutritional supplement alpha-lipoic acid degrades rapidly on exposure to temperatures above its melting point 65 degrees C and to light.
Bhardwaj, Rajni M. +6 more
core +1 more source
TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]
, 2012 Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Abdul HM +60 more
core +1 more source
Cell & Bioscience, 2011 Haloperidol is an antipsychotic drug that exerts its' antipsychotic effects by inhibiting dopaminergic neurons. Although the exact pathophysiology of haloperidol extrapyramidal symptoms are not known, the role of reactive oxygen species in inducing ...
Perera Joachim +4 more
doaj +1 more source
Autoimmune hypoglycemia due to alpha-lipoic acid: Report of two cases.
J Postgrad MedSubramaniam K, Tom B.
europepmc +2 more sources
The Application of Lipoic Acid in Experimentally Induced Tympanosclerosis in Rats
Journal of Contemporary Medicine, 2020 Background/Aims:Tympanosclerosis is an abnormal tissue reaction resulting in sclerotic and hyalinization changes in the tympanic membrane and middle ear.
Fatih Turan +2 more
doaj +1 more source