The Host Non-Coding RNA Response to Alphavirus Infection [PDF]
Viruses, 2023 Alphaviruses are important human and animal pathogens that can cause a range of debilitating symptoms and are found worldwide. These include arthralgic diseases caused by Old-World viruses and encephalitis induced by infection with New-World alphaviruses.
Mahgol Behnia, Steven B. Bradfute
doaj +6 more sources
siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection. [PDF]
PLoS Pathogens, 2016 Little is known about the repertoire of cellular factors involved in the replication of pathogenic alphaviruses. To uncover molecular regulators of alphavirus infection, and to identify candidate drug targets, we performed a high-content imaging-based ...
Sheli R Radoshitzky +19 more
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Entry receptors — the gateway to alphavirus infection [PDF]
The Journal of Clinical Investigation, 2023 Alphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis, encephalitis, and death. Over the past
Ofer Zimmerman +4 more
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Alphavirus infection triggers antiviral RNAi immunity in mammals [PDF]
Cell Reports, 2023 Summary: RNA interference (RNAi) is a well-established antiviral immunity. However, for mammalian somatic cells, antiviral RNAi becomes evident only when viral suppressors of RNAi (VSRs) are disabled by mutations or VSR-targeting drugs, thereby limiting ...
Jing Kong +7 more
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High costs of infection: Alphavirus infection reduces digestive function and bone and feather growth in nestling house sparrows (Passer domesticus). [PDF]
PLoS ONE, 2018 Increasingly, ecoimmunology studies aim to use relevant pathogen exposure to examine the impacts of infection on physiological processes in wild animals.
Carol A Fassbinder-Orth +4 more
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Deciphering the Role of Schwann Cells in Inflammatory Peripheral Neuropathies Post Alphavirus Infection [PDF]
Cells, 2022 Old world alphaviruses (e.g., chikungunya) are known to cause severe acute and chronic debilitating arthralgia/arthritis. However, atypical neurological manifestations and, in particular, unexpected cases of acute inflammatory Guillain–Barre syndrome ...
Yosra Bedoui +6 more
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Subgenomic reporter RNA system for detection of alphavirus infection in mosquitoes. [PDF]
PLoS ONE, 2013 Current methods for detecting real-time alphavirus (Family Togaviridae) infection in mosquitoes require the use of recombinant viruses engineered to express a visibly detectable reporter protein.
J Jordan Steel +4 more
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Granulocyte colony-stimulating factor protects against acute systemic alphavirus disease in a type I IFN-dependent manner [PDF]
Frontiers in ImmunologyIntroductionArthritogenic alphaviruses, including chikungunya (CHIKV) and Mayaro virus (MAYV), cause disease characterized by fever, rash, and incapacitating joint pain.
Muddassar Hameed +10 more
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Antiviral activity of glucosylceramide synthase inhibitors in alphavirus infection of the central nervous system. [PDF]
Brain Commun, 2023 Avraham R +9 more
europepmc +3 more sources
Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K with Well-Characterized Viroporins [PDF]
VirusesViruses encode ion channel proteins called viroporins to assist in infection and immune evasion. The alphavirus 6K protein is classified as a member of the viroporin family of proteins.
Vashi Negi +2 more
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