Deciphering the Role of Schwann Cells in Inflammatory Peripheral Neuropathies Post Alphavirus Infection [PDF]
Cells, 2022 Old world alphaviruses (e.g., chikungunya) are known to cause severe acute and chronic debilitating arthralgia/arthritis. However, atypical neurological manifestations and, in particular, unexpected cases of acute inflammatory Guillain–Barre syndrome ...
Yosra Bedoui +6 more
doaj +5 more sources
Entry receptors — the gateway to alphavirus infection [PDF]
The Journal of Clinical Investigation, 2023 Alphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis, encephalitis, and death. Over the past
Ofer Zimmerman +4 more
doaj +6 more sources
The Host Non-Coding RNA Response to Alphavirus Infection [PDF]
Viruses, 2023 Alphaviruses are important human and animal pathogens that can cause a range of debilitating symptoms and are found worldwide. These include arthralgic diseases caused by Old-World viruses and encephalitis induced by infection with New-World alphaviruses.
Mahgol Behnia, Steven B. Bradfute
doaj +5 more sources
Distinct Cellular Tropism and Immune Responses to Alphavirus Infection. [PDF]
Annu Rev Immunol, 2022 Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging from incapacitating arthritis to potentially fatal encephalitis.
Kafai NM, Diamond MS, Fox JM.
europepmc +6 more sources
Alphavirus infection triggers antiviral RNAi immunity in mammals [PDF]
Cell Reports, 2023 Summary: RNA interference (RNAi) is a well-established antiviral immunity. However, for mammalian somatic cells, antiviral RNAi becomes evident only when viral suppressors of RNAi (VSRs) are disabled by mutations or VSR-targeting drugs, thereby limiting ...
Jing Kong +7 more
doaj +5 more sources
Agua Salud Alphavirus Infection, Dissemination and Transmission in <i>Aedes aegypti</i> Mosquitoes. [PDF]
Viruses, 2023 Mosquitoes are competent vectors for many important arthropod-borne viruses (arboviruses). In addition to arboviruses, insect-specific viruses (ISV) have also been discovered in mosquitoes.
Jagtap SV +8 more
europepmc +4 more sources
High costs of infection: Alphavirus infection reduces digestive function and bone and feather growth in nestling house sparrows (Passer domesticus). [PDF]
PLoS ONE, 2018 Increasingly, ecoimmunology studies aim to use relevant pathogen exposure to examine the impacts of infection on physiological processes in wild animals.
Carol A Fassbinder-Orth +4 more
doaj +5 more sources
Selective Estrogen Receptor Modulators Limit Alphavirus Infection by Targeting the Viral Capping Enzyme nsP1. [PDF]
Antimicrob Agents Chemother, 2022 Alphaviruses cause animal or human diseases that are characterized by febrile illness, debilitating arthralgia, or encephalitis. Selective estrogen receptor modulators (SERMs), a class of FDA-approved drugs, have been shown to possess antiviral ...
Mudgal R +8 more
europepmc +4 more sources
Mosquitoes as Vectors of Mycobacterium ulcerans Based on Analysis of Notifications of Alphavirus Infection and Buruli Ulcer, Victoria, Australia. [PDF]
Emerg Infect DisAlphavirus infections are transmitted by mosquitoes, but the mode of transmission for Mycobacterium ulcerans, which causes Buruli ulcer, is contested. Using notification data for Victoria, Australia, during 2017–2022, adjusted for incubation period, we ...
Buultjens AH +5 more
europepmc +3 more sources
Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture [PDF]
Nature CommunicationsAlphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming.
Vasiliya Kril +16 more
doaj +3 more sources