Neurological Sequelae Resulting from Encephalitic Alphavirus Infection. [PDF]
Front Microbiol, 2016 The recent surge in viral clinical cases and associated neurological deficits have reminded us that viral infections can lead to detrimental, long-term effects, termed sequelae, in survivors. Alphaviruses are enveloped, single-stranded positive-sense RNA
Ronca SE, Dineley KT, Paessler S.
europepmc +6 more sources
siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection. [PDF]
PLoS Pathogens, 2016 Little is known about the repertoire of cellular factors involved in the replication of pathogenic alphaviruses. To uncover molecular regulators of alphavirus infection, and to identify candidate drug targets, we performed a high-content imaging-based ...
Sheli R Radoshitzky +19 more
doaj +6 more sources
Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection. [PDF]
Front Microbiol, 2017 Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. In human survivors, alphavirus encephalitis can cause severe neurobehavioral changes, in the most extreme cases, a schizophrenic ...
Ronca SE +6 more
europepmc +6 more sources
Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis. [PDF]
J Virol, 2018 Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide range of outbreaks and crippling disease, the availability of licensed vaccines or antiviral therapies remains limited.
Fong SW, Kini RM, Ng LFP.
europepmc +5 more sources
Inflammatory monocytes mediate control of acute alphavirus infection in mice. [PDF]
PLoS Pathog, 2017 Chikungunya virus (CHIKV) and Ross River virus (RRV) are mosquito-transmitted alphaviruses that cause debilitating acute and chronic musculoskeletal disease.
Haist KC +3 more
europepmc +6 more sources
Innate immune control of alphavirus infection. [PDF]
Curr Opin Virol, 2018 Alphaviruses are important human pathogens that cause diseases ranging from acute and chronic polyarthralgia to encephalitis. Transmitted by mosquito vectors, alphaviruses have high potential for emergence and have initiated several recent epidemics. The innate immune response is critical for controlling the acute phase of alphavirus disease, and the ...
Carpentier KS, Morrison TE.
europepmc +5 more sources
Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses. [PDF]
Viruses, 2016 Alphaviruses cause debilitating disease in humans and animals and are transmitted by blood-feeding arthropods, typically mosquitoes. With a traditional focus on two models, Sindbis virus and Semliki Forest virus, alphavirus research has significantly ...
Fros JJ, Pijlman GP.
europepmc +7 more sources
Effects of ploidy and salmonid alphavirus infection on the skin and gill microbiome of Atlantic salmon (Salmo salar). [PDF]
PLoS One, 2021 The microbial communities that live in symbiosis with the mucosal surfaces of animals provide the host with defense strategies against pathogens. These microbial communities are largely shaped by the environment and the host genetics.
Brown R +4 more
europepmc +2 more sources
Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila. [PDF]
Cell Rep, 2019 Zhang R +10 more
europepmc +4 more sources
High-Throughput Fluorescence-Based Screen Identifies the Neuronal MicroRNA miR-124 as a Positive Regulator of Alphavirus Infection. [PDF]
J Virol, 2020 Arthropod-borne (arbo) viruses are part of a class of pathogens that are transmitted to their final hosts by insects. Because of climate change, the habitat of some of these insects, such as mosquitoes, is shifting, thereby facilitating the emergence of ...
López P +12 more
europepmc +2 more sources