Results 11 to 20 of about 17,945 (225)
Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection. [PDF]
Front Microbiol, 2017 Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. In human survivors, alphavirus encephalitis can cause severe neurobehavioral changes, in the most extreme cases, a schizophrenic-like syndrome. In the present study, we aimed to adapt an animal model of alphavirus infection survival
Ronca SE +6 more
europepmc +6 more sources
Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing gn protects mice against Rift Valley fever virus. [PDF]
PLoS Neglected Tropical Diseases, 2010 Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas.
Nitin Bhardwaj, Mark T Heise, Ted M Ross
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Sequelae and Animal Modeling of Encephalitic Alphavirus Infections [PDF]
Viruses, 2023 Eastern (EEEV), Venezuelan (VEEV), and western equine encephalitis viruses (WEEV) are members of the genus Alphavirus, family Togaviridae. Typically spread by mosquitoes, EEEV, VEEV, and WEEV induce febrile illness that may develop into more severe encephalitic disease, resulting in myriad severe neurologic sequelae for which there are no vaccines or ...
Rachel A. Reyna, Scott C. Weaver
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Innate immune control of alphavirus infection. [PDF]
Curr Opin Virol, 2018 Alphaviruses are important human pathogens that cause diseases ranging from acute and chronic polyarthralgia to encephalitis. Transmitted by mosquito vectors, alphaviruses have high potential for emergence and have initiated several recent epidemics. The innate immune response is critical for controlling the acute phase of alphavirus disease, and the ...
Carpentier KS, Morrison TE.
europepmc +4 more sources
Noncapped Alphavirus Genomic RNAs and Their Role during Infection [PDF]
Journal of Virology, 2015 ABSTRACT Alphaviruses are enveloped positive-sense RNA viruses that exhibit a wide host range consisting of vertebrate and invertebrate species. Previously we have reported that the infectivity of Sindbis virus (SINV), the model alphavirus, was largely a function of the cell line producing the viral particles.
Kevin J. Sokoloski +4 more
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Effect of alphavirus infection on mouse embryos [PDF]
Infection and Immunity, 1982 Seven strains and mutants of the alphaviruses, Semliki Forest virus and Sindbis virus, differed in their lethality for mouse embryos and their mothers. The A7 strain and the neurovirulence mutant M103 of Semliki Forest virus were selected for detailed comparison. A7 produced 100% lethality of mouse embryos but was avirulent for their mothers.
Gerald J. Atkins +2 more
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Distinct Cellular Tropism and Immune Responses to Alphavirus Infection. [PDF]
Annu Rev Immunol, 2022 Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic and encephalitic alphaviruses results in distinct clinical manifestations, both virus groups induce robust innate and adaptive immune responses.
Kafai NM, Diamond MS, Fox JM.
europepmc +3 more sources
Identification of Genes Involved in the Host Response to Neurovirulent Alphavirus Infection [PDF]
Journal of Virology, 2001 ABSTRACTSingle-amino-acid mutations in Sindbis virus proteins can convert clinically silent encephalitis into uniformly lethal disease. However, little is known about the host gene response during avirulent and virulent central nervous system (CNS) infections.
Christine Johnston +3 more
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Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis. [PDF]
J Virol, 2018 ABSTRACT Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide range of outbreaks and crippling disease, the availability of licensed vaccines or antiviral therapies remains limited. Mosquito vectors such as Aedes and Culex
Fong SW, Kini RM, Ng LFP.
europepmc +5 more sources
Arthritogenic Alphavirus Capsid Protein
Life, 2021 In the past two decades Old World and arthritogenic alphavirus have been responsible for epidemics of polyarthritis, causing high morbidity and becoming a major public health concern. The multifunctional arthritogenic alphavirus capsid protein is crucial
Shambhavi Rao, Adam Taylor
doaj +1 more source