First Record of Mosquito-Borne Kyzylagach Virus in Central Europe
Viruses, 2020 RNA of Kyzylagach virus (KYZV), a Sindbis-like mosquito-borne alphavirus from Western equine encephalitis virus complex, was detected in four pools (out of 221 pools examined), encompassing 10,784 female Culex modestus mosquitoes collected at a fishpond ...
Silvie Šikutová +8 more
doaj +1 more source
Inflammatory monocytes mediate control of acute alphavirus infection in mice. [PDF]
PLoS Pathog, 2017 Chikungunya virus (CHIKV) and Ross River virus (RRV) are mosquito-transmitted alphaviruses that cause debilitating acute and chronic musculoskeletal disease. Monocytes are implicated in the pathogenesis of these infections; however, their specific roles are not well defined.
Haist KC +3 more
europepmc +5 more sources
The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]
, 2016 Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S +4 more
core +2 more sources
Berberine Chloride is an Alphavirus Inhibitor That Targets Nucleocapsid Assembly
mBio, 2020 Alphaviruses are enveloped positive-sense RNA viruses that can cause serious human illnesses such as polyarthritis and encephalitis. Despite their widespread distribution and medical importance, there are no licensed vaccines or antivirals to combat ...
Judy J. Wan +2 more
doaj +1 more source
Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry. [PDF]
PLoS Pathogens, 2013 The enveloped alphaviruses include important and emerging human pathogens such as Chikungunya virus and Eastern equine encephalitis virus. Alphaviruses enter cells by clathrin-mediated endocytosis, and exit by budding from the plasma membrane.
Yaw Shin Ooi +4 more
doaj +1 more source
Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]
, 2018 Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel +13 more
core +3 more sources
Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller +9 more
doaj +1 more source
Early Events in Alphavirus Replication Determine the Outcome of Infection [PDF]
Journal of Virology, 2012 ABSTRACT Alphaviruses are a group of important human and animal pathogens. They efficiently replicate to high titers in vivo and in many commonly used cell lines of vertebrate origin. They have also evolved effective means of interfering with development of the innate immune response. Nevertheless, most of
Ilya Frolov +4 more
openalex +4 more sources
Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]
PLoS Pathogens, 2012 The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani +4 more
doaj +1 more source
The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies
Cell Reports, 2021 Summary: Although neutralizing monoclonal antibodies (mAbs) against epitopes within the alphavirus E2 protein can protect against infection, the functional significance of non-neutralizing mAbs is poorly understood.
James T. Earnest +5 more
doaj +1 more source