4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo
mBioChikungunya virus (CHIKV) is an enveloped, positive-sense RNA virus that has re-emerged to cause millions of human infections worldwide. In humans, acute CHIKV infection causes fever and severe muscle and joint pain.
Peiqi Yin +14 more
openalex +2 more sources
Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation [PDF]
npj Parkinson's Disease, 2019 Neuroinvasive infections with mosquito-borne alphaviruses such as Western equine encephalitis virus (WEEV) can cause post-encephalitic parkinsonism. To understand the mechanisms underlying these neurological effects, we examined the capacity of WEEV to ...
Collin M. Bantle +5 more
openalex +2 more sources
Hidden in Plain Sight: Alphavirus Persistence and Its Potential for Driving Chronic Pathogenesis [PDF]
VirusesAlphaviruses have historically been viewed as acute, self-limiting pathogens. However, growing evidence shows that viral RNA and antigens can persist in vertebrate hosts long after the resolution of acute infection, a phenomenon known as viral ...
Maria del Mar Villanueva Guzman +3 more
doaj +2 more sources
In Vitro Analyses of the Multifocal Effects of Natural Alkaloids Berberine, Matrine, and Tabersonine against the O'nyong-nyong Arthritogenic Alphavirus Infection and Inflammation. [PDF]
Pharmaceuticals (Basel), 2023 Sandenon Seteyen AL +4 more
europepmc +3 more sources
RNA processing bodies are disassembled during Old World alphavirus infection.
Journal of General Virology, 2019 RNA processing bodies (P-bodies) are non-membranous cytoplasmic aggregates of mRNA and proteins involved in mRNA decay and translation repression. P-bodies actively respond to environmental stresses, associated with another type of RNA granules, known as
Lifeng Liu +6 more
semanticscholar +3 more sources
The Role of Innate Cells During Alphavirus Chikungunya Infection [PDF]
VirusesAlphavirus chikungunya (CHIKV) is an arthropod-borne alphavirus of the Togaviridae family, transmitted primarily by Aedes aegypti and Ae. albopictus mosquitoes.
Juliane Santos de França da Silva +9 more
doaj +2 more sources
PLoS Pathogens, 2015 Arthritogenic alphaviruses, including Ross River virus (RRV) and chikungunya virus (CHIKV), are responsible for explosive epidemics involving millions of cases. These mosquito-transmitted viruses cause inflammation and injury in skeletal muscle and joint
Kristina S. Burrack +6 more
openalex +3 more sources
Encapsidated Host Factors in Alphavirus Particles Influence Midgut Infection of Aedes aegypti [PDF]
Viruses, 2018 Transmission of mosquito-borne viruses requires the efficient infection of both a permissive vertebrate host and a competent mosquito vector. The infectivity of Sindbis virus (SINV), the type species of the Alphavirus genus, is influenced by both the ...
David Mackenzie-Liu +3 more
openalex +2 more sources
Variable effects of Wolbachia on alphavirus infection in Aedes aegypti [PDF]
, 2023 2.AbstractWolbachia pipientis(=Wolbachia) has promise as a tool to suppress virus transmission byAedes aegyptimosquitoes. However,Wolbachiacan have variable effects on mosquito-borne viruses. This variation remains poorly characterized, yet the multimodal effects ofWolbachiaon diverse pathogens could have important implications for public health. Here,
Brittany L. Dodson +4 more
openalex +3 more sources