Interactions of Alphavirus nsP3 Protein with Host Proteins
Frontiers in Microbiology, 2018 Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus ...
Tyler Lark +2 more
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Selective precipitation reaction: a novel diagnostic test for tissue pathology in Atlantic Salmon, Salmo salar, infected with Salmonid Alpha-Virus (SAV3) [PDF]
, 2017 While investigating biomarkers for infection with salmonid alphavirus (SAV), the cause of pancreas disease (PD), a selective precipitation reaction (SPR) has been discovered in serum which could be an on-farm qualitative test and an in-laboratory ...
Adams +20 more
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PLoS Neglected Tropical Diseases, 2017 Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments.
Elysse N Grossi-Soyster +9 more
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Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells [PDF]
, 2013 The exogenous siRNA pathway is important in restricting arbovirus infection in mosquitoes. Less is known about the role of the PIWI-interacting RNA pathway, or piRNA pathway, in antiviral responses. Viral piRNA-like molecules have recently been described
Donald, Claire L. +8 more
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Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection [PDF]
, 2012 Dynamic, mRNA-containing stress granules (SGs) form in the cytoplasm of cells under environmental stresses, including viral infection. Many viruses appear to employ mechanisms to disrupt the formation of SGs on their mRNAs, suggesting that they represent
Eng, Kai Er +6 more
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Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape
Microorganisms, 2021 Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta +2 more
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ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication. [PDF]
, 2019 Cellular antiviral programs encode molecules capable of targeting multiple steps in the virus lifecycle. Zinc-finger antiviral protein (ZAP) is a central and general regulator of antiviral activity that targets pathogen mRNA stability and translation ...
Jurado, Andrea +6 more
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Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers
Virology, 2008 The genus Alphavirus contains members that threaten human health, both as natural pathogens and as potential biological weapons. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) enter cells readily and can inhibit viral replication through sequence-specific steric blockade of viral RNA.
Slobodan Paessler +11 more
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Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection. [PDF]
J Neuroimmunol, 2017 Cain MD +8 more
europepmc +3 more sources
Perturbation of alphavirus and flavivirus infectivity by components of the bacterial cell wall [PDF]
Journal of Virology, 2021 AbstractThe impact of the host microbiota on arbovirus infections is currently not well understood. Arboviruses are viruses transmitted through the bites of infected arthropods, predominantly mosquitoes or ticks. The first site of arbovirus inoculation is the biting site in the host skin, which is colonized by a complex microbial community that could ...
Lana Langendries +7 more
openaire +3 more sources