Results 51 to 60 of about 3,257,979 (198)

DDX56 Binds to Chikungunya Virus RNA To Control Infection

mBio, 2020
DEAD box RNA helicases regulate diverse facets of RNA biology. Proteins of this family carry out essential cellular functions, and emerging literature is revealing additional roles in immune defense.
Frances Taschuk, Iulia Tapescu, Ryan H. Moy, Sara Cherry   +3 more
doaj   +1 more source

A molecular understanding of alphavirus entry.

PLoS Pathogens, 2020
Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway ...
Autumn C Holmes, Katherine Basore, Daved H Fremont, Michael S Diamond   +3 more
doaj   +1 more source

First Record of Mosquito-Borne Kyzylagach Virus in Central Europe

Viruses, 2020
RNA of Kyzylagach virus (KYZV), a Sindbis-like mosquito-borne alphavirus from Western equine encephalitis virus complex, was detected in four pools (out of 221 pools examined), encompassing 10,784 female Culex modestus mosquitoes collected at a fishpond ...
Silvie Šikutová, Patrik Dočkal, Petra Straková, Jan Mendel, Oldřich Šebesta, Lenka Betášová, Hana Blažejová, Zdeněk Hubálek, Ivo Rudolf   +8 more
doaj   +1 more source

Berberine Chloride is an Alphavirus Inhibitor That Targets Nucleocapsid Assembly

mBio, 2020
Alphaviruses are enveloped positive-sense RNA viruses that can cause serious human illnesses such as polyarthritis and encephalitis. Despite their widespread distribution and medical importance, there are no licensed vaccines or antivirals to combat ...
Judy J. Wan, Rebecca S. Brown, Margaret Kielian   +2 more
doaj   +1 more source

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry. [PDF]

PLoS Pathogens, 2013
The enveloped alphaviruses include important and emerging human pathogens such as Chikungunya virus and Eastern equine encephalitis virus. Alphaviruses enter cells by clathrin-mediated endocytosis, and exit by budding from the plasma membrane.
Yaw Shin Ooi, Katie M Stiles, Catherine Y Liu, Gwen M Taylor, Margaret Kielian   +4 more
doaj   +1 more source

Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller, Petra Clowes, Gerhard Dobler, Elmar Saathoff, Inge Kroidl, Nyanda Elias Ntinginya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, Norbert Heinrich   +9 more
doaj   +1 more source

Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito soma. [PDF]

PLoS Pathogens, 2012
The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral ...
Elaine M Morazzani, Michael R Wiley, Marta G Murreddu, Zach N Adelman, Kevin M Myles   +4 more
doaj   +1 more source

The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies

Cell Reports, 2021
Summary: Although neutralizing monoclonal antibodies (mAbs) against epitopes within the alphavirus E2 protein can protect against infection, the functional significance of non-neutralizing mAbs is poorly understood.
James T. Earnest, Autumn C. Holmes, Katherine Basore, Matthias Mack, Daved H. Fremont, Michael S. Diamond   +5 more
doaj   +1 more source

Interactions of Alphavirus nsP3 Protein with Host Proteins

Frontiers in Microbiology, 2018
Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus ...
Tyler Lark, Forrest Keck, Aarthi Narayanan   +2 more
doaj   +1 more source

Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya.

PLoS Neglected Tropical Diseases, 2017
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments.
Elysse N Grossi-Soyster, Elizabeth A J Cook, William A de Glanville, Lian F Thomas, Amy R Krystosik, Justin Lee, C Njeri Wamae, Samuel Kariuki, Eric M Fèvre, A Desiree LaBeaud   +9 more
doaj   +1 more source