PLoS Pathogens, 2023 Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central America.
Emmely E Treffers +6 more
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Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]
, 2019 Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna +3 more
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Current Understanding of the Role of Cholesterol in the Life Cycle of Alphaviruses
Viruses, 2020 Enveloped viruses rely on different lipid classes present in cell membranes to accomplish several steps of their life cycle in the host. Particularly for alphaviruses, a medically important group of arboviruses, which are part of the Togaviridae family ...
Ivanildo P. Sousa +2 more
doaj +1 more source
Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges [PDF]
, 2014 Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal health, yet effective control measures have proven difficult to implement, and novel means of controlling their replication in arthropod vectors, such as mosquitoes, are
Dietrich, Isabelle +3 more
core +1 more source
Pathogenesis of experimental salmonid alphavirus infection in vivo: an ultrastructural insight. [PDF]
Vet Res, 2016 Salmonid alphavirus (SAV) is an enveloped, single-stranded, positive sense RNA virus belonging to the family Togaviridae. It causes economically devastating disease in cultured salmonids. The characteristic features of SAV infection include severe histopathological changes in the heart, pancreas and skeletal muscles of diseased fish.
Herath TK +8 more
europepmc +7 more sources
The Alphavirus Sindbis Infects Enteroendocrine Cells in the Midgut of Aedes aegypti [PDF]
Viruses, 2020 Transit of the arthropod-borne-virus (arbovirus) Sindbis (SINV) throughout adult female mosquitoes initiates with its attachment to the gut lumen, entry and amplification in midgut cells, followed by dissemination into the hemolymph. Free-mated adult females, aged day 5–7, were proffered a viremic blood suspension via sausage casings containing SINV ...
Ahearn, Yani P. +2 more
openaire +4 more sources
Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]
, 2015 Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K. +10 more
core +1 more source
Intercellular Extensions Are Induced by the Alphavirus Structural Proteins and Mediate Virus Transmission. [PDF]
PLoS Pathogens, 2016 Alphaviruses are highly organized enveloped RNA viruses with an internal nucleocapsid surrounded by a membrane containing the E2 and E1 transmembrane proteins.
Maria Guadalupe Martinez +1 more
doaj +1 more source
Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses. [PDF]
Viruses, 2016 Alphaviruses cause debilitating disease in humans and animals and are transmitted by blood-feeding arthropods, typically mosquitoes. With a traditional focus on two models, Sindbis virus and Semliki Forest virus, alphavirus research has significantly intensified in the last decade partly due to the re-emergence and dramatic expansion of chikungunya ...
Fros JJ, Pijlman GP.
europepmc +7 more sources
The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]
, 2018 The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S +6 more
core +2 more sources