Results 61 to 70 of about 3,257,979 (198)

Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape

Microorganisms, 2021
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta, Rhonda Sin-Ling Chee, Lisa F.P. Ng   +2 more
doaj   +1 more source

Noncapped Alphavirus Genomic RNAs and Their Role during Infection [PDF]

Journal of Virology, 2015
ABSTRACT Alphaviruses are enveloped positive-sense RNA viruses that exhibit a wide host range consisting of vertebrate and invertebrate species. Previously we have reported that the infectivity of Sindbis virus (SINV), the model alphavirus, was largely a function of the cell line producing the viral particles.
K J, Sokoloski, K C, Haist, T E, Morrison, S, Mukhopadhyay, R W, Hardy   +4 more
openaire   +2 more sources

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.

PLoS Pathogens, 2023
Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central America.
Emmely E Treffers, Ali Tas, Florine E M Scholte, Arnoud H de Ru, Eric J Snijder, Peter A van Veelen, Martijn J van Hemert   +6 more
doaj   +1 more source

Alphavirus Transducing System: Tools for Visualizing Infection in Mosquito Vectors [PDF]

Journal of Visualized Experiments, 2010
Alphavirus transducing systems (ATSs) are important tools for expressing genes of interest (GOI) during infection. ATSs are derived from cDNA clones of mosquito-borne RNA viruses (genus Alphavirus; family Togaviridae). The Alphavirus genus contains about 30 different mosquito-borne virus species.
Aaron, Phillips, Eric, Mossel, Irma, Sanchez-Vargas, Brian, Foy, Ken, Olson   +4 more
openaire   +2 more sources

Current Understanding of the Role of Cholesterol in the Life Cycle of Alphaviruses

Viruses, 2020
Enveloped viruses rely on different lipid classes present in cell membranes to accomplish several steps of their life cycle in the host. Particularly for alphaviruses, a medically important group of arboviruses, which are part of the Togaviridae family ...
Ivanildo P. Sousa, Carlos A. M. Carvalho, Andre M. O. Gomes   +2 more
doaj   +1 more source

Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing gn protects mice against Rift Valley fever virus. [PDF]

PLoS Neglected Tropical Diseases, 2010
Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas.
Nitin Bhardwaj, Mark T Heise, Ted M Ross
doaj   +1 more source

Intercellular Extensions Are Induced by the Alphavirus Structural Proteins and Mediate Virus Transmission. [PDF]

PLoS Pathogens, 2016
Alphaviruses are highly organized enveloped RNA viruses with an internal nucleocapsid surrounded by a membrane containing the E2 and E1 transmembrane proteins.
Maria Guadalupe Martinez, Margaret Kielian   +1 more
doaj   +1 more source

Ly6C+ monocytes in the skin promote systemic alphavirus dissemination

Cell Reports
Summary: Alphaviruses are mosquito-transmitted pathogens that induce high levels of viremia, which facilitates dissemination and vector transmission. One prevailing paradigm is that, after skin inoculation, alphavirus-infected resident dendritic cells ...
Autumn C. Holmes, Cormac J. Lucas, Morgan E. Brisse, Brian C. Ware, Heather D. Hickman, Thomas E. Morrison, Michael S. Diamond   +6 more
doaj   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Macrophage migration inhibitory factor receptor CD74 mediates alphavirus-induced arthritis and myositis in murine models of alphavirus infection. [PDF]

Arthritis & Rheumatism, 2013
ObjectiveArthrogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV) circulate worldwide. This virus class causes debilitating illnesses that are characterized by arthritis, arthralgia, and myalgia. In previous studies, we identified macrophage migration inhibitory factor (MIF) as a critical inflammatory factor in the ...
Lara J. Herrero, K. Sheng, Peng Jian, Adam Taylor, Z. Her, B. Herring, A. Chow, Y. Leo, M. Hickey, E. Morand, L. Ng, R. Bucala, S. Mahalingam   +12 more
semanticscholar   +4 more sources